Results 181 to 190 of about 14,295 (215)

Plasma biomarkers of Alzheimer's disease

Current Opinion in Psychiatry, 2008
The importance of biomarkers of Alzheimer's disease is increasing. The present review aims to offer a general view of plasma biomarkers of Alzheimer's disease and to discuss their relevance and limitations.The broad overlap in the plasma amyloid beta protein (Abeta) levels between patients with Alzheimer's disease and control individuals indicates that
Takeshi, Kawarabayashi, Mikio, Shoji
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Genetic architecture of plasma Alzheimer’s disease biomarkers

Alzheimer's & Dementia, 2023
AbstractBackgroundCase‐control genome‐wide association studies (GWAS) have identified loci associated with risk for Alzheimer disease (AD), but they require very large sample sizes and identify variants with small effect sizes. GWAS of informative endophenotypes for disease have more power to identify novel variants and provide information about ...
Joseph Bradley, Priyanka Gorijala, Suzanne E Schindler, Yun J Sung, Beau Ances, Nilüfer Ertekin-Taner, Steven Younkin, Todd Golde, Nathan Price, David Bennett, Christopher Gaiteri, Philip De Jager, Bin Zhang, Eric Schadt, Michelle Ehrlich, Vahram Haroutunian, Sam Gandy, Koichi Iijima, Scott Noggle, Lara Mangravite, Maria V Fernandez, Carlos Cruchaga   +21 more
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Plasma globotriaosylsphingosine as a biomarker of Fabry disease

Molecular Genetics and Metabolism, 2010
Fabry disease is an X-linked genetic disorder caused by a deficiency of alpha-galactosidase A (GLA) activity. As enzyme replacement therapy (ERT) involving recombinant GLAs has been introduced for this disease, a useful biomarker for diagnosis and monitoring of therapy has been strongly required.
Tadayasu, Togawa, Takashi, Kodama, Toshihiro, Suzuki, Kanako, Sugawara, Takahiro, Tsukimura, Toya, Ohashi, Nobuyuki, Ishige, Ken, Suzuki, Teruo, Kitagawa, Hitoshi, Sakuraba   +9 more
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Mining the plasma proteome for cancer biomarkers

Nature, 2008
Systematic searches for plasma proteins that are biological indicators, or biomarkers, for cancer are underway. The difficulties caused by the complexity of biological-fluid proteomes and tissue proteomes (which contribute proteins to plasma) and by the extensive heterogeneity among diseases, subjects and levels of sample procurement are gradually ...
Samir M, Hanash, Sharon J, Pitteri, Vitor M, Faca   +2 more
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Plasma metabolomics reveals biomarkers of the atherosclerosis

Journal of Separation Science, 2010
AbstractAtherosclerotic cardiovascular disease remains the leading cause of morbidity and mortality in industrialized societies. The lack of metabolite biomarkers has impeded the clinical diagnosis of atherosclerosis so far. In this study, stable atherosclerosis patients (n=16) and age‐ and sex‐matched non‐atherosclerosis healthy subjects (n=28) were ...
Chen, Xi, Liu, Lian, Palacios, Gustavo, Gao, Jie, Zhang, Ning, Li, Guang, Lu, Juan, Song, Ting, Zhang, Yingzhi, Lu, Haitao   +9 more
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Plasma proteins as biomarkers of the aging process

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1995
This study was designed to characterize the rat serum proteins as biomarkers of the normal aging process. Crossed immunoelectrophoresis or electroimmunodiffusion quantitation of proteins was performed in rats aged 6, 12, 24, and 30 mo. Selection of healthy animals was based on confrontation of crossed immunoelectrophoresis patterns with those of ...
R, Vranckx, L, Savu, N, Lambert, G V, de Conchard, R, Grosse, M S, Mourey, B, Corman   +6 more
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Plasma biomarkers for Alzheimer’s

C&EN Global Enterprise, 2018
Protein clumps called amyloids accumulate in the brains of people with Alzheimer’s disease. The current methods for detecting amyloids—positron emission tomography (PET) imaging of the brain and measurement of the clumping protein amyloid-β in cerebrospinal fluid—are expensive and invasive.
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Optimization of SELDI for Biomarker Detection in Plasma

2010
The surface-enhanced laser desorption ionization (SELDI) technology is a promising approach not only for the research of biomarkers in the blood of patients in clinical applications but also in preclinical studies to assess the drug-induced toxicities.
Jean-Francois, Léonard, Martine, Courcol, Jean-Charles, Gautier   +2 more
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Plasma Fibrinogen as a Biomarker in Gynecologic Cancers

Personalized Medicine, 2011
Coagulation & cancer Coagulation and cancer progression have been demonstrated to be closely related. For example, tumor cells produce procoagulant factors such as fibrinogen [1], which in turn promotes tumor angiogenesis by interacting with growth factors such as FGF-2 and VEGF [2,3]. In addition, fibrinogen and fibrin facilitate binding between tumor
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Plasma microRNAs as biomarkers in hereditary angioedema

Annals of Allergy, Asthma & Immunology
Hereditary angioedema (HAE) is an autosomal dominant disease with variable expression. In some families with identical genetic abnormalities, the expression can range from several attacks per month to no attacks at all. It is hypothesized that post-transcriptional gene regulation accounts for the variable expression of the disease.To identify candidate
Timothy, Craig, Kristina, Richwine, Faoud T, Ishmael   +2 more
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