Results 51 to 60 of about 383,796 (264)

Untargeted metabolomics reveals immune-metabolic signatures in established cases of rheumatoid arthritis

Frontiers in Molecular Biosciences
IntroductionRheumatoid arthritis (RA) is a complex progressive autoimmune disorder wherein chronic inflammation is tightly coupled to metabolic reprogramming. The known diagnostic markers are not sensitive and specific enough to reflect disease activity.
Afshan Masood, Afshan Masood, Reem Almalki, Abeer Malkawi, Maha Al Mogren, Amal Jaafar, Hicham Benabdelkamel, Assim A. Alfadda, Assim A. Alfadda, Assim A. Alfadda, Amina Fallata, Abdurhman S. Alarfaj, Mohamed Siaj, Anas M. Abdel Rahman, Anas M. Abdel Rahman   +14 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Cerebrospinal fluid and plasma biomarker trajectories with increasing amyloid deposition in Alzheimer's disease

EMBO Molecular Medicine, 2019
Failures in Alzheimer's disease (AD) drug trials highlight the need to further explore disease mechanisms and alterations of biomarkers during the development of AD.
Sebastian Palmqvist, Philip S Insel, Erik Stomrud, Shorena Janelidze, Henrik Zetterberg, Britta Brix, Udo Eichenlaub, Jeffrey L Dage, Xiyun Chai, Kaj Blennow, Niklas Mattsson, Oskar Hansson   +11 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Diagnostic performance of plasma p-Tau217, p-Tau181, and p-Tau231 across the Alzheimer’s disease continuum: a network meta-analysis

Frontiers in Aging Neuroscience
ImportanceBlood-based biomarkers (BBMs) are transforming the diagnostic workflow for Alzheimer’s disease (AD). However, there is no consensus on the optimal phosphorylated tau (p-tau) isoform (217, 181, or 231) or analytical platform [mass spectrometry ...
Xiaofen Chen, Tingting Huang, Chao Shi, Shuizhi Xu, Shuwei Fan   +4 more
doaj   +1 more source

Plasma Biomarkers in a Mouse Model of Preterm Labor [PDF]

Pediatric Research, 2009
Preterm labor (PTL) is frequently associated with inflammation. We hypothesized that biomarkers during pregnancy can identify pregnancies most at risk for development of PTL. An inflammation-induced mouse model of PTL was used. Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry was used to analyze and compare the plasma ...
Qing, Yang, John C, Whitin, Xuefeng Bruce, Ling, Nihar R, Nayak, Harvey J, Cohen, Joseph, Jin, James, Schilling, Tom To-Sang, Yu, Ashima, Madan   +8 more
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Detection of lung allograft injury through a comprehensive multidisciplinary analysis of donor-derived cell-free DNA in plasma and bronchoalveolar lavage: a real-world single center experience

Frontiers in Immunology
IntroductionPlasma donor-derived cell-free DNA (dd-cfDNA) is an emerging potential tool for diagnosing lung graft injury. This study explored the relevance of dd-cfDNA levels in different graft injuries thoroughly characterized after a well-established ...
Fiorella Calabrese, Federica Pezzuto, Luca Vedovelli, Cecilia De Chellis, Francesca Lunardi, Monica Loy, Eleonora Faccioli, Marta Vadori, Davide Biondini, Serena Marinello, Fausto Braccioni, Federica Meloni, Marco Schiavon, Chiara Giraudo, Claudia Del Vecchio, Deborah J. Levine, Emanuele Cozzi, Federico Rea   +17 more
doaj   +1 more source

Cross‐sectional and longitudinal evaluation of plasma glial fibrillary acidic protein to detect and predict clinical syndromes of Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023
Introduction This study examined plasma glial fibrillary acidic protein (GFAP) as a biomarker of cognitive impairment due to Alzheimer's disease (AD) with and against plasma neurofilament light chain (NfL), and phosphorylated tau (p‐tau)181+231.
Madeline Ally, Michael A. Sugarman, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton, Thomas K. Karikari, Hugo J. Aparicio, Brandon Frank, Yorghos Tripodis, Brett Martin, Joseph N. Palmisano, Eric G. Steinberg, Irene Simkin, Lindsay A. Farrer, Gyungah R. Jun, Katherine W. Turk, Andrew E. Budson, Maureen K. O'Connor, Rhoda Au, Lee E. Goldstein, Neil W. Kowall, Ronald Killiany, Robert A. Stern, Thor D. Stein, Ann C. McKee, Wei Qiao Qiu, Jesse Mez, Michael L. Alosco   +27 more
doaj   +1 more source