Results 201 to 210 of about 3,013,542 (232)
ESCRT Machinery Is Required for Plasma Membrane Repair
Science, 2014 ESCRT Your Wound Away The ESCRT (endosomal sorting complex required for transport) protein complex plays a role in budding into multivesicular bodies, in cytokinesis, and in HIV budding. Now, Jimenez et al. (p.
Paolo Maiuri, Franck Perez
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Annexins Bend Wound Edges During Plasma Membrane Repair
Current Medicinal Chemistry, 2020 The plasma membrane of eukaryotic cells defines the boundary to the extracellular environment and, thus provides essential protection from the surroundings. Consequently, disruptions to the cell membrane triggered by excessive mechanical or biochemical stresses pose fatal threats to cells, which they need to cope with to survive.
Jesper Nylandsted +2 more
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Phenothiazines Alter Plasma Membrane Properties and Sensitize Cancer Cells to Injury by Inhibiting Annexin-Mediated Repair [PDF]
Journal of Biological Chemistry, 2021 Repair of damaged plasma membrane in eukaryotic cells is largely dependent on the binding of annexin repair proteins to phospholipids. Changing the biophysical properties of the plasma membrane may provide means to compromise annexin-mediated repair and ...
Stine Lauritzen Sønder +2 more
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Annexins in Plasma Membrane Repair
Biological Chemistry, 2016Abstract Disruption of the plasma membrane poses deadly threat to eukaryotic cells and survival requires a rapid membrane repair system. Recent evidence reveal various plasma membrane repair mechanisms, which are required for cells to cope with membrane lesions including membrane fusion and replacement strategies, remodeling of cortical ...
Jesper Nylandsted, Theresa Louise Boye
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Lysosomes and Plasma Membrane Repair
Current Topics in Membranes, 2019The ability of repairing damages on the plasma membrane is crucial for cell survival. When damaged, eukaryotic cells are able to recover plasma membrane integrity within a few seconds, thus avoiding cytoplasm leakage and cell death. The process is driven by the influx of extracellular calcium which triggers a multitude of intracellular effects that ...
Thiago Castro-Gomes, Matthias Corrotte
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Structural and Signaling Role of Lipids in Plasma Membrane Repair [PDF]
Current Topics in Membranes, 2019 The plasma membrane forms the physical barrier between the cytoplasm and extracellular space, allowing for biochemical reactions necessary for life to occur. Plasma membrane damage needs to be rapidly repaired to avoid cell death. This relies upon the coordinated action of the machinery that polarizes the repair response to the site of injury ...
Adam Horn, Jyoti K. Jaiswal
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Cellular Mechanisms and Signals That Coordinate Plasma Membrane Repair [PDF]
Cellular and Molecular Life Sciences, 2018 Plasma membrane forms the barrier between the cytoplasm and the environment. Cells constantly and selectively transport molecules across their plasma membrane without disrupting it. Any disruption in the plasma membrane compromises its selective permeability and is lethal, if not rapidly repaired.
Adam Horn, Jyoti K. Jaiswal
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Plasma membrane repair in plants
Trends in Plant Science, 2009Resealing is the membrane-repair process that enables cells to survive disruption, preventing the loss of irreplaceable cell types and eliminating the cost of replacing injured cells. Given that failure in the resealing process in animal cells causes diverse types of muscular dystrophy, plasma membrane repair has been extensively studied in these ...
Arnaldo L, Schapire +2 more
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Ceramide in Plasma Membrane Repair
2013The perforation of the plasmalemma by pore-forming toxins causes an influx of Ca(2+) and an efflux of cytoplasmic proteins. In order to ensure cellular survival, lesions have to be identified, plugged and removed from the membrane. The Ca(2+)-driven fusion of lysosomes with the plasma membrane leads to hydrolysis of sphingomyelin by acid ...
Draeger A, Babiychuk EB
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Plasma Membrane Disruption: Repair, Prevention, Adaptation
Annual Review of Cell and Developmental Biology, 2003▪ Abstract Many metazoan cells inhabit mechanically stressful environments and, consequently, their plasma membranes are frequently disrupted. Survival requires that the cell rapidly repair or reseal the disruption. Rapid resealing is an active and complex structural modification that employs endomembrane as its primary building ...
Paul L, McNeil, Richard A, Steinhardt
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