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Plasma membrane repair in plants
Trends in Plant Science, 2009Resealing is the membrane-repair process that enables cells to survive disruption, preventing the loss of irreplaceable cell types and eliminating the cost of replacing injured cells. Given that failure in the resealing process in animal cells causes diverse types of muscular dystrophy, plasma membrane repair has been extensively studied in these ...
Arnaldo L, Schapire +2 more
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Plasma membrane repair empowers the necrotic survivors as innate immune modulators [PDF]
Seminars in Cell and Developmental BiologyShiqi Xu, Suhong Xu, Yi-Nan Gong
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Dealing with damage: Plasma membrane repair mechanisms
Biochimie, 2014Eukaryotic cells have developed repair mechanisms, which allow them to reseal their membrane in order to prevent the efflux of cytoplasmic constituents and the uncontrolled influx of calcium. After injury, the Ca(2+)-concentration gradient fulfils a dual function: it provides guidance cues for the repair machinery and directly activates the molecules ...
Draeger A +4 more
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Ceramide in Plasma Membrane Repair
2013The perforation of the plasmalemma by pore-forming toxins causes an influx of Ca(2+) and an efflux of cytoplasmic proteins. In order to ensure cellular survival, lesions have to be identified, plugged and removed from the membrane. The Ca(2+)-driven fusion of lysosomes with the plasma membrane leads to hydrolysis of sphingomyelin by acid ...
Draeger A, Babiychuk EB
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Lysosomes and plasma membrane repair
2019The ability of repairing damages on the plasma membrane is crucial for cell survival. When damaged, eukaryotic cells are able to recover plasma membrane integrity within a few seconds, thus avoiding cytoplasm leakage and cell death. The process is driven by the influx of extracellular calcium which triggers a multitude of intracellular effects that ...
Matthias, Corrotte, Thiago, Castro-Gomes
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Plasma Membrane Disruption: Repair, Prevention, Adaptation
Annual Review of Cell and Developmental Biology, 2003▪ Abstract  Many metazoan cells inhabit mechanically stressful environments and, consequently, their plasma membranes are frequently disrupted. Survival requires that the cell rapidly repair or reseal the disruption. Rapid resealing is an active and complex structural modification that employs endomembrane as its primary building block, and ...
Paul L, McNeil, Richard A, Steinhardt
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Dysferlin and the plasma membrane repair in muscular dystrophy
Trends in Cell Biology, 2004Muscular dystrophy covers a group of genetically determined disorders that cause progressive weakness and wasting of the skeletal muscles. Dysferlin was identified as a gene mutated in limb-girdle muscular dystrophy (type 2B) and Miyoshi myopathy. The discovery of dysferlin revealed a new family of proteins, known as the ferlin family, which includes ...
Dimple, Bansal, Kevin P, Campbell
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Annexins and plasma membrane repair
2019Plasma membrane wound repair is a cell-autonomous process that is triggered by Ca2+ entering through the site of injury and involves membrane resealing, i.e., re-establishment of a continuous plasma membrane, as well as remodeling of the cortical actin cytoskeleton.
Sophia N, Koerdt +2 more
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Plasma membrane disruption (PMD) formation and repair in mechanosensitive tissues
Bone, 2021Mammalian cells employ an array of biological mechanisms to detect and respond to mechanical loading in their environment. One such mechanism is the formation of plasma membrane disruptions (PMD), which foster a molecular flux across cell membranes that promotes tissue adaptation. Repair of PMD through an orchestrated activity of molecular machinery is
Mackenzie L, Hagan +2 more
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Mitochondria for plasma membrane repair
Science, 2017Cell Biology Mechanical strain on cells can cause damage to the plasma membrane that must be repaired before extracellular Ca2+ influx reaches levels that trigger cell death. Horn et al. found that mitochondria mediated the repair of plasma membrane injuries in mouse muscle cells and human nonmuscle cells (see the Focus by Cooper).
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