Results 211 to 220 of about 173,214 (234)
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Ceramide in Plasma Membrane Repair
2013The perforation of the plasmalemma by pore-forming toxins causes an influx of Ca(2+) and an efflux of cytoplasmic proteins. In order to ensure cellular survival, lesions have to be identified, plugged and removed from the membrane. The Ca(2+)-driven fusion of lysosomes with the plasma membrane leads to hydrolysis of sphingomyelin by acid ...
Draeger A, Babiychuk EB
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Annexins Bend Wound Edges during Plasma Membrane Repair
Current Medicinal Chemistry, 2020The plasma membrane of eukaryotic cells defines the boundary to the extracellular environment and, thus provides essential protection from the surroundings. Consequently, disruptions to the cell membrane triggered by excessive mechanical or biochemical stresses pose fatal threats to cells, which they need to cope with to survive.
Jesper Nylandsted +2 more
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Lysosomes and plasma membrane repair
2019The ability of repairing damages on the plasma membrane is crucial for cell survival. When damaged, eukaryotic cells are able to recover plasma membrane integrity within a few seconds, thus avoiding cytoplasm leakage and cell death. The process is driven by the influx of extracellular calcium which triggers a multitude of intracellular effects that ...
Matthias, Corrotte, Thiago, Castro-Gomes
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Plasma Membrane Disruption: Repair, Prevention, Adaptation
Annual Review of Cell and Developmental Biology, 2003▪ Abstract  Many metazoan cells inhabit mechanically stressful environments and, consequently, their plasma membranes are frequently disrupted. Survival requires that the cell rapidly repair or reseal the disruption. Rapid resealing is an active and complex structural modification that employs endomembrane as its primary building block, and ...
Paul L, McNeil, Richard A, Steinhardt
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Dysferlin and the plasma membrane repair in muscular dystrophy
Trends in Cell Biology, 2004Muscular dystrophy covers a group of genetically determined disorders that cause progressive weakness and wasting of the skeletal muscles. Dysferlin was identified as a gene mutated in limb-girdle muscular dystrophy (type 2B) and Miyoshi myopathy. The discovery of dysferlin revealed a new family of proteins, known as the ferlin family, which includes ...
Dimple, Bansal, Kevin P, Campbell
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Annexins and plasma membrane repair
2019Plasma membrane wound repair is a cell-autonomous process that is triggered by Ca2+ entering through the site of injury and involves membrane resealing, i.e., re-establishment of a continuous plasma membrane, as well as remodeling of the cortical actin cytoskeleton.
Sophia N, Koerdt +2 more
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Plasma membrane disruption (PMD) formation and repair in mechanosensitive tissues
Bone, 2021Mammalian cells employ an array of biological mechanisms to detect and respond to mechanical loading in their environment. One such mechanism is the formation of plasma membrane disruptions (PMD), which foster a molecular flux across cell membranes that promotes tissue adaptation. Repair of PMD through an orchestrated activity of molecular machinery is
Mackenzie L, Hagan +2 more
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Annexins are instrumental for efficient plasma membrane repair in cancer cells
Seminars in Cell and Developmental Biology, 2015Plasma membrane stress can cause damage to the plasma membrane, both when imposed by the extracellular environment and by enhanced oxidative stress. Cells cope with these injuries by rapidly activating their plasma membrane repair system, which is triggered by Ca(2+) influx at the wound site.
Jesper Nylandsted, Theresa Louise Boye
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Mitochondria for plasma membrane repair
Science, 2017Cell Biology Mechanical strain on cells can cause damage to the plasma membrane that must be repaired before extracellular Ca2+ influx reaches levels that trigger cell death. Horn et al. found that mitochondria mediated the repair of plasma membrane injuries in mouse muscle cells and human nonmuscle cells (see the Focus by Cooper).
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Plasma membrane repair: the adaptable cell life-insurance
Current Opinion in Cell Biology, 2017The plasma membrane is the most basic element necessary for the cell to exist and be distinguishable from its environment. Regulated mechanisms allow tightly controlled communication between intacellular and extracellular medium allowing the maintenance of a specific biochemical environment, optimized for cellular functions.
Jimene, Ana Joaquina, Perez, Franck
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