Results 211 to 220 of about 3,013,542 (232)

Dysferlin and the plasma membrane repair in muscular dystrophy

Trends in Cell Biology, 2004
Muscular dystrophy covers a group of genetically determined disorders that cause progressive weakness and wasting of the skeletal muscles. Dysferlin was identified as a gene mutated in limb-girdle muscular dystrophy (type 2B) and Miyoshi myopathy. The discovery of dysferlin revealed a new family of proteins, known as the ferlin family, which includes ...
Dimple, Bansal, Kevin P, Campbell
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Annexins and plasma membrane repair

2019
Plasma membrane wound repair is a cell-autonomous process that is triggered by Ca2+ entering through the site of injury and involves membrane resealing, i.e., re-establishment of a continuous plasma membrane, as well as remodeling of the cortical actin cytoskeleton.
Sophia N, Koerdt, Arsila P K, Ashraf, Volker, Gerke   +2 more
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Plasma membrane disruption (PMD) formation and repair in mechanosensitive tissues

Bone, 2021
Mammalian cells employ an array of biological mechanisms to detect and respond to mechanical loading in their environment. One such mechanism is the formation of plasma membrane disruptions (PMD), which foster a molecular flux across cell membranes that promotes tissue adaptation. Repair of PMD through an orchestrated activity of molecular machinery is
Mackenzie L, Hagan, Vanshika, Balayan, Meghan E, McGee-Lawrence   +2 more
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Annexins Are Instrumental for Efficient Plasma Membrane Repair in Cancer Cells

Seminars in Cell and Developmental Biology, 2015
Plasma membrane stress can cause damage to the plasma membrane, both when imposed by the extracellular environment and by enhanced oxidative stress. Cells cope with these injuries by rapidly activating their plasma membrane repair system, which is triggered by Ca(2+) influx at the wound site.
Jesper Nylandsted, Theresa Louise Boye
exaly   +3 more sources

Mitochondria for plasma membrane repair

Science, 2017
Cell Biology Mechanical strain on cells can cause damage to the plasma membrane that must be repaired before extracellular Ca2+ influx reaches levels that trigger cell death. Horn et al. found that mitochondria mediated the repair of plasma membrane injuries in mouse muscle cells and human nonmuscle cells (see the Focus by Cooper).
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Plasma membrane repair: the adaptable cell life-insurance

Current Opinion in Cell Biology, 2017
The plasma membrane is the most basic element necessary for the cell to exist and be distinguishable from its environment. Regulated mechanisms allow tightly controlled communication between intacellular and extracellular medium allowing the maintenance of a specific biochemical environment, optimized for cellular functions.
Jimene, Ana Joaquina, Perez, Franck
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Mechanistic Insights Into the Dynamics of Plasma Membrane Repair in Cancer

Molecular Biology Reports
Cancer cells are well equipped with plasma membrane repair to survive mechanical tension, chemical stress, immune assaults and therapeutic interventions. Maintaining plasma membrane integrity is quintessential for tumor cells as it plays a pivotal role in communication between the internal environment of the tumor cell and the extracellular ...
Muhammad Muddassir Ali
exaly   +3 more sources

Repairing plasma membrane damage in regulated necrotic cell death

Molecular Biology Reports, 2021
The plasma membrane performs a central role in maintaining cellular homeostasis and viability by acting as a semi-permeable barrier separating the cell from its surroundings. Under physiological conditions, it is constantly exposed to different kinds of stress, such as from pore-forming proteins/toxins and mechanical activity, that compromises its ...
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Sealing and healing: A two-step model for plasma membrane repair

Developmental Cell
Plasma membrane damage can cause cell death and is associated with neurodegeneration. In this issue of Developmental Cell, Heffner et al. show that annexin A11 (ANXA11) first plugs membrane lesions, before ESCRT-III is recruited to extrude the damaged patch-a two-step repair mechanism compromised by ALS- and FTD-linked mutations.
Athanasios Kournoutis, Harald Stenmark
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Plasma membrane repair involvement in parasitic and other pathogen infections

2019
Intracellular pathogens depend on specific mechanisms to be able to gain entry and survive into their host cells. For this, they subvert pathways involved in physiological cellular processes. Here we are going to focus on how two protozoan parasites, Trypanosoma cruzi and Leishmania sp, which may cause severe diseases in humans, use plasma membrane ...
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