Results 111 to 120 of about 2,029,441 (265)

MetaboSense: An Integrated Quantum Dot‐Mediated Aptamer Assay and Modular Microfluidic Platform for Continuous In‐Line Monitoring of Lung Metabolism During Ex Vivo Perfusion

Advanced Science, EarlyView.
MetaboSense is a first‐of‐its‐kind microfluidic platform enabling continuous, in‐line monitoring of glucose and lactate during ex vivo lung perfusion. Combining a quantum dot–mediated aptamer assay with mixing, depletion, and optofluidic detection modules, it achieves 60–s temporal resolution and shows strong agreement with standard blood gas analyzers,
Sanjana Srikant, Pouyan Keshavarz Motamed, Thomas Borrillo, Lielle Ronen, Gabriel Siebiger, Guillermo Garza, Hesam Abouali, Md Fahim Al Fattah, Ines Jaber, Dayan Ban, Marcelo Cypel, Mingyao Liu, Shaf Keshavjee, Andrew T. Sage, Mahla Poudineh   +14 more
wiley   +1 more source

Metabolites from blood and formalin-fixed, paraffin-embedded tissue from participants with low- and high-grade prostate cancer: a pilot study

Frontiers in Oncology
BackgroundIdentifying metabolites associated with prostate cancer (Pca) aggressiveness may elucidate mechanisms underlying disease severity. Doing so in plasma and formalin-fixed, paraffin-embedded (FFPE) tissue may accelerate discovery.
Rebecca E. Graff, Henrik L. Bengtsson, Jung H. Suh, Adam B. Olshen, Adam B. Olshen, Elizabeth Y. Wang, Ryan M. Allen, Erin L. Van Blarigan, Erin L. Van Blarigan, Stacey A. Kenfield, Janet E. Cowan, Peter R. Carroll, Jeff Simko, June M. Chan, June M. Chan   +14 more
doaj   +1 more source

Appendix B. Dichlorodiphenyltrichloroethane (DDT) metabolites measured in Black-footed and Laysan Albatross plasma samples.

, 2016
Dichlorodiphenyltrichloroethane (DDT) metabolites measured in Black-footed and Laysan Albatross plasma ...
Bradford S. Keitt (2904116), Donald A. Croll (196386), Sue Rodriguez-Pastor (2904113), David J. Anderson (268361), Myra Finkelstein (93002), Bernie Tershy (423631), Paul R. Sievert (268372), Walter M. Jarman (2904119), Donald R. Smith (324290)   +8 more
core   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

The differential metabolites in the plasma between C3H-FB and C3H control mice.

, 2016
The differential metabolites in the plasma between C3H-FB and C3H control mice.
Guobing Zhong (3178971), Dongjing Yan (3178965), Huazong Zeng (304005), Wangwei Cai (3178968), Guankui Du (3178974), Man Xiao (556153)   +5 more
core   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Identification of belinostat metabolites in human plasma using HPLC-DAD & LC-MS/MS analyses.

, 2013
Identification of belinostat metabolites in human plasma using HPLC-DAD & LC-MS/MS analyses.
Win-Lwin Thuya (277890), Mark J. Ratain (25629), Boon-Cher Goh (142783), Sherry Ansher (277899), Winnie Yeo (197426), Ling-Zhi Wang (277888), Jie-Ying Amelia Lau (277891), Soo-Chin Lee (132913), Robert Lim (277895), Seow-Ching Wan (277892), How-Sung Lee (277897), Jacqueline Ramírez (5651281), Ying-Kiat Zee (277894), Anthony Chan (277898), Mei-Yi Michelle Chan (277889), Andrea Li-Ann Wong (277893), Paul C. Ho (277896)   +16 more
core   +1 more source

A Micropeptide Component of the OGDH Complex Modulates ATP Production in the TCA Cycle

Advanced Science, EarlyView.
This study identified a mitochondrial micropeptide encoded by a non‐canonical open reading frame (alt‐ORF) within the CTSB gene. This micropeptide named APPM (ATP production‐promoting micropeptide) is a novel component of the OGDHc complex in the TCA cycle. APPM localizes to the inner mitochondrial membrane and directly binds to OGDH, the E1 subunit of
Xinqiang Yin, Weiyan Qi, Lifen Lin, Huilin Zheng, Guoxiang Zhao, Quan Chen, Guoqiang Shao, Yifan Wu, Jialiang Hu, Hanmei Xu   +9 more
wiley   +1 more source

Causal relationships between metabolic syndrome, plasma metabolites, and female reproductive diseases: insights from a two-step mendelian randomization approach

Nutrition & Metabolism
Background Female reproductive diseases—including endometriosis (EMs), uterine fibroids (UFs), polycystic ovary syndrome (PCOS), gestational diabetes mellitus (GDM), eclampsia, ectopic pregnancy (EP), infertility, miscarriage, and ovarian aging—pose ...
Li Li, Juanjuan Ma, Ningyu Sun, Panwei Hu, Yi Lin, Qinhua Zhang   +5 more
doaj   +1 more source

TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis

Advanced Science, EarlyView.
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu, Tiancheng Li, Yu Jin, Yixin Li, Qicheng Liu, Runzhe Fang, Luyao Qu, Xinyue Tang, Ruomei Li, Xiaoyue Zhao, Jin Hao, Bing Fang, Lunguo Xia   +12 more
wiley   +1 more source