Results 171 to 180 of about 2,029,441 (265)

Dietary patterns and osteoporosis risk in a high-altitude population: the roles of gut microbiota and plasma metabolites in a case-control study. [PDF]

Front Nutr
Zhang L, Wu X, Chen X, Xin H, Yan J, Zhuo M, Ma X, Liu X, Liu M, Huang G, Ma F.   +10 more
europepmc   +1 more source

Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node‐Targeting and Augments mRNA Vaccine Efficacy

Advanced Science, EarlyView.
Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha, Jaehyun Kim, Seyoung Kim, Gonna Somu Naidu, Sungchan Cho, Seok‐Beom Yong   +5 more
wiley   +1 more source

Effect of Letrozole Administration on Reproductive Performance and Plasma Metabolites of Ewes During Estrus Synchronization Treatment. [PDF]

Life (Basel)
Li T, Wang X, Lu H, Lu T, Reyilaguli R, Lv H, Liu X, Zhang J, Li S, Xiao R, Zhao G.   +10 more
europepmc   +1 more source

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Plasma metabolites, dietary intakes, and breast cancer incidence: a prospective case-cohort study in NutriNet-Santé. [PDF]

Am J Clin Nutr
Larnder AH, Murphy RA, Srour B, Déchamp N, Galan P, Hercberg S, Bourhis L, Díaz C, Genilloud O, Touvier M, Deschasaux-Tanguy M.   +10 more
europepmc   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

Gut Microbial Topology and Metabolic Signatures Associated With Colorectal Neoplasia

Advanced Science, EarlyView.
The gut microbiota organizes into two robust association patterns linked to colorectal neoplasia risk. Topological shifts in microbial networks are associated with metabolite alterations and may shape host responses during disease development. ABSTRACT Alterations of gut microbial communities impact health.
Kai Song, Youwen Qin, Jiahui Luo, Liping Liu, Chenyu Luo, Yinbin Qiu, Yiyi Zhong, Huanzi Zhong, Kui Wu, Meng Ni, Dong Wu, Min Dai, Shida Zhu, Hongda Chen   +13 more
wiley   +1 more source

Dissecting Causal Relationship Among Immune Cells, Plasma Metabolites and Coronary Atherosclerosis: A Mendelian Randomization Study

ImmunoTargets and Therapy
Qi Cao, Jiajing Liu, Jingyu Sun, Shuangshuang Qian, Junhuai Song, Haoyang Zheng, Jinkun Wen, Bin Zheng Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University ...
Cao Q, Liu J, Sun J, Qian S, Song J, Zheng H, Wen J, Zheng B   +7 more
doaj  

Fibrinogen-associated plasma metabolites and implications for coagulation, inflammation, and vascular diseases. [PDF]

J Thromb Haemost
Nicholas JC, Alkis T, Bis JC, Boerwinkle E, Brody JA, Clish CB, de Vries PS, Gao Y, Gerzsten RE, Guo X, Johnson AD, Larson MG, Lemaitre RN, Psaty BM, Vasan RS, Reiner AP, Rich SS, Rodriguez B, Rong J, Rotter JI, Simino J, Smith NL, Wilson J, Yao J, Morrison AC, Yu B, Raffield LM.   +26 more
europepmc   +1 more source

Metal–Phenolic Complexation Governs Soil Mineral Crystallinity to Enhance Crop Growth

Advanced Science, EarlyView.
A coordination‐driven, coprecipitation approach is presented to obtain polyphenolic‐incorporated minerals with tunable crystallinity, offering insights into how plants may influence soil mineral structures. Soil minerals can incorporate polyphenolic secondary metabolites and enhance plant nutrition by facilitating the formation of amorphous metal ...
Jong‐Rok Jeon, Omid Mazaheri, Tianzheng Wang, Ali Zavabeti, Ho Young Yoon, Nguyen Thanh Phong, Eun‐Nam Joe, Zhixing Lin, Shuaijun Pan, Chan‐Jin Kim, Frank Caruso   +10 more
wiley   +1 more source