Results 201 to 210 of about 2,029,441 (265)

Plasma metabolites after 10-weeks of glucose vs fructose-sweetened beverages in subjects with overweight/obesity. [PDF]

J Endocr Soc
Guirette M, Haslam DE, Ma J, Havel PJ, Stanhope KL, Ilkayeva O, Newgard CB, McKeown NM, Herman MA.   +8 more
europepmc   +1 more source

Nuciferine Suppresses Inflammatory Hepatocarcinogenesis by Targeting cPLA2‐Dependent Arachidonic Acid Metabolism

Advanced Science, EarlyView.
Nuciferine directly binds the C2 domain of cPLA2, impairing its Ca2+‐dependent membrane translocation and activation. By suppressing arachidonic acid release and downstream pro‐inflammatory eicosanoid production, nuciferine attenuates NF‐κB signaling and inflammatory hepatocarcinogenesis, revealing cPLA2 as a direct molecular target underlying its ...
Jing Sun, Xinyan Wu, Shuwei Luo, Yilang Liu, Jie Liu, Jun Lu, Weimin Wang, Xiao Feng, Tuo Zhang, Dipak Panigrahy, Jianjun Deng, Xiaojun Liao, Haixia Yang   +12 more
wiley   +1 more source

Causal Relationships Between Plasma Metabolites and Risk of Dermatomyositis. [PDF]

Clin Cosmet Investig Dermatol
Qin W, Tian J, Qiu Y, Bao X, Yang S.
europepmc   +1 more source

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

The gut microbiota and plasma metabolites on functional dyspepsia: a study integrating Mendelian randomization and experimental validation. [PDF]

Front Med (Lausanne)
Hu X, Zhang X, Yang C, Chen L, Yang R, Wang C, Wu S, Ma L, Jiang W, Deng P, Su X, Wei W.   +11 more
europepmc   +1 more source

HADHA K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer

Advanced Science, EarlyView.
HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng, Qinlian Jiao, Jiankang Zhu, Yidan Ren, Xiaoyu Teng, Xin Su, Zigan Li, Yuxuan Cai, Xiaoyan Liu, Yunshan Wang, Guangyong Zhang   +10 more
wiley   +1 more source

Longitudinal Study of Plasma Metabolites During Menopause and Their Associations With Later Onset of Metabolic Syndrome.

J Clin Endocrinol Metab
Miyake A, Iida M, Harada S, Sugiyama D, Matsumoto M, Miyagawa N, Toki R, Edagawa S, Hirata A, Kuwabara K, Okamura T, Sato A, Amano K, Hirayama A, Sugimoto M, Soga T, Tomita M, Arakawa K, Kisu I, Yamagami W, Takebayashi T.   +20 more
europepmc   +1 more source

VCP‐Regulated LMF2 Stabilizes the Cholesterol Biosynthesis Enzyme HMGCS1 to Drive Cancer Progression and Confer Capecitabine Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
LMF2 drives progression and capecitabine resistance in triple‐negative breast cancer (TNBC). Mechanistically, VCP prevents NBR1‐mediated autophagic degradation of LMF2, thereby stabilizing it. Stabilized LMF2 subsequently suppresses NDP52‐mediated autophagic degradation of HMGCS1, a rate‐limiting cholesterol biosynthesis enzyme.
Qian Zhao, Lisa Andriani, Yin‐Ling Zhang, Shao‐Ying Yang, Yun‐Xiao Ling, Min‐Ying Huang, Jia‐Yang Cai, Fang‐Lin Zhang, Xin Hu, A‐Yong Cao, Zhi‐Min Shao, Guang‐Yu Liu, Da‐Qiang Li   +12 more
wiley   +1 more source

Anxiety Disorder Types From a Metabolomics Perspective: A Mendelian Randomization Analysis Based on 1400 Plasma Metabolites. [PDF]

Brain Behav
Xiao Z, Wu Z, Chen Z, Xu Z, Zhou Q, Liu S, Wang M, Hou S, Liu W, Li Z, Xun K, Zhang N, Wang C.   +12 more
europepmc   +1 more source

Loss of Intestinal MSTN Promotes GLP‐1 Secretion Through SGLT1 Palmitoylation

Advanced Science, EarlyView.
Intestinal MSTN deficiency enhances glucose‐stimulated GLP‐1 secretion and glucose tolerance in high‐fat diet‐fed mice. Mechanistically, loss of MSTN promotes YY1‐associated ZDHHC20 expression, increasing SGLT1 S‐palmitoylation at Cys301 and its plasma membrane localization in L cells.
Sheng‐Zhong Han, Shuang‐Yan Chang, Zhaobo Luo, Ke Sun, Biaohu Quan, Yanqiu Lv, Zhouyan Li, Xinyue Liu, Sitong Lv, Meifu Xuan, Xiaoyufan Xu, Xue Fang, Hang Chang, Rihuan Zhang, Xi‐Jun Yin, Lin‐Hu Quan, Jin‐Dan Kang   +16 more
wiley   +1 more source