Results 91 to 100 of about 4,892,488 (246)

microRNA downregulation in plasmacytoid dendritic cells in interferon-positive systemic lupus erythematosus and antiphospholipid syndrome [PDF]

, 2018
To investigate miRNA expression in relation to transcriptomic changes in plasmacytoid dendritic cells (pDCs) in SLE and APS.
Aridaman Pandit, van den Hoogen, Lucas L, Rossato, Marzia, Pandit, Aridaman, Marzia Rossato, Bekker, Cornelis P J, van Roon, Joel A G, Lucas L van den Hoogen, Cornelis P J Bekker, Ruth D E Fritsch-Stork, Lopes, Ana P, Joel A G van Roon, Ana P Lopes, Radstake, Timothy R D J, Fritsch-Stork, Ruth D E, Timothy R D J Radstake   +15 more
core   +1 more source

Human Plasmacytoid Dendritic Cells and Cutaneous Melanoma

Cells, 2020
The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has ...
Matilde Monti, Francesca Consoli, Raffaella Vescovi, Mattia Bugatti, William Vermi   +4 more
doaj   +1 more source

Blastic plasmacytoid dendritic cell neoplasm: diagnostic criteria and therapeutical approaches [PDF]

, 2016
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare haematological malignancy derived from the precursors of plamacytoid dendritic cells, with an aggressive clinical course and high frequency of cutaneous and bone marrow involvement ...
GRAMMATICO, SARA, Alessandro Pulsoni, Valentini, Caterina Giovanna, Sara Grammatico, Valentini, Caterina G, PULSONI, Alessandro, Livio Pagano, Caterina G. Valentini, Pagano, Livio, Garcia Vera, Jorge Andres, Araujo Reyes, Angelica Patricia, Anaya Reyes, Katty Camila   +11 more
core   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

Nail Lichen Planus in Children ‐ Epidemiology, Pathogenesis, Clinical Presentation, and Treatment

JEADV Clinical Practice, EarlyView.
ABSTRACT Nail lichen planus (NLP) is a chronic inflammatory disorder that, while rare in children compared to adults, represents a significant cause of pediatric nail dystrophy that requires early recognition to prevent permanent scarring and nail loss.
Francesca Pampaloni, Matilde Iorizzo
wiley   +1 more source

Letter to Nature. Viral infection switches non-plasmacytoid dendritic cells into high interferon producers

, 2003
Type I interferons (IFN-I) are important cytokines linking innate and adaptive immunity. Plasmacytoid dendritic cells make high levels of IFN-I in response to viral infection and are thought to be the major source of the cytokines in vivo.
Richard Flavell, Linsey E. Haswell, Hermann Unger, Montoya, Maria, Alexopoulou, Lena, Diebold, Sandra S, Al-Shamkhani, Aymen, Sousa, Caetano Reis E, Persephone Borrow, Maria Montoya, Aymen Al-Shamkhani, Diebold, Sandra, Flavell, Richard, Roy, Polly, Haswell, Linsey E., Unger, Hermann, Borrow, Persephone, Haswell, Linsey E, Caetano Reis e Sousa, Haswell, Linsey, Sandra S. Diebold, Polly Roy, Lena Alexopoulou, Diebold, Sandra S., Reis e Sousa, Caetano   +24 more
core   +1 more source

Immune responses against classical swine fever virus: between ignorance and lunacy

Frontiers in Veterinary Science, 2015
Classical swine fever virus infection of pigs causes disease courses from life-threatening to asymptomatic, depending on the virulence of the virus strain and the immunocompetence of the host.
Artur eSummerfield, Nicolas eRuggli
doaj   +1 more source

Pembrolizumab‐Induced Subacute Cutaneous Lupus Erythematosus: A Case Report

JEADV Clinical Practice, EarlyView.
ABSTRACT Subacute cutaneous lupus erythematosus (SCLE) is an increasingly recognized cutaneous immune‐related adverse event of immune checkpoint inhibitors. We report an 83‐year‐old woman who developed pruritic annular and polycyclic plaques 10 weeks after starting pembrolizumab for oropharyngeal squamous cell carcinoma.
Sebastiano Posenato, Alba Guglielmo, Lucia Mantovani, Aikaterini Kalpaktsoglou, Simone Cavaliere, Alessandro Borghi   +5 more
wiley   +1 more source

Role of plasmacytoid dendritic cells in lung-associated inflammation.

, 2010
Plasmacytoid Dendritic Cells (pDCs) are important immune orchestrators. One of the most important features of pDCs is the high production of IFN type I that can promote the polarization of T cells towards a Th1 phenotype.
PINTO, Aldo, MORELLO, SILVANA, SORRENTINO, ROSALINDA, Silvana Morello, Rosalinda Sorrentino, Aldo Pinto   +5 more
core   +1 more source

Characteristics of “Tip-DCs and MDSCs” and their potential role in leishmaniasis [PDF]

, 2012
Since the first description of dendritic cells (DCs) by Steinman and Cohn (1973), the myeloid lineage of leukocytes was investigated intensively. Nowadays it is obvious that myeloid cells, especially DCs, are crucial for the adaptive and innate immune ...
Schmid, Maximilian, Anja Kathrin Wege, Maximilian eSchmid, Uwe eRitter, Anja K. Wege, Maximilian Schmid, Uwe Ritter, Ritter, Uwe, Wege, Anja K.   +8 more
core   +1 more source