Results 71 to 80 of about 4,892,488 (246)

HADHA K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer

Advanced Science, EarlyView.
HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng, Qinlian Jiao, Jiankang Zhu, Yidan Ren, Xiaoyu Teng, Xin Su, Zigan Li, Yuxuan Cai, Xiaoyan Liu, Yunshan Wang, Guangyong Zhang   +10 more
wiley   +1 more source

Mechanical Distraction Engages a Neuro‐Immune Program to Drive Regenerative Soft‐Tissue Healing in Ilizarov Bone Transport

Advanced Science, EarlyView.
Ilizarov bone transport accelerates healing of soft‐tissue wounds through unclear mechanisms. In a rat model, sustained mechanical distraction elicits calcitonin gene‐related peptide (CGRP)‐dominant sensory reinnervation, creating a niche that shifts immune cells from inflammatory to repair‐promoting states and speeds re‐epithelialization.
Yueliang Zhu, Jiayu Chen, Xuehuan Wen, Kaijia Tang, Ling Gao, Chenxing Wang, Yixuan Feng, Si‐He Qin, Tao Chen, Xiaohua Yu   +9 more
wiley   +1 more source

Fuyuan Huoxue Decoction Promotes Lumbar Interbody Fusion in Rats: Role of Macrophage‐Driven Inflammation and the TLR9/NF‐κB Pathway

Advanced Science, EarlyView.
Fuyuan Huoxue decoction improves lumbar interbody fusion in rats while reducing inflammatory macrophage activity and supporting bone‐forming stem cells. Experiments implicate extracellular DNA and TLR9/NF‐κB signaling in early responses. These findings point to coordinated control of inflammation and osteogenesis as a potential route to stronger spinal
Hongwei Gao, Han Wu, Shaorong Li, Weijian Wang, Yijian Guo, Shuai Cheng, Jiayi Sun, Jilong An, Wei Zhang   +8 more
wiley   +1 more source

Compositions for reprogramming cells into plasmacytoid dendritic cells or interferon producing cells, methods and uses thereof

, 2021
The present disclosure relates to compositions, constructs and vectors for reprogramming cells into plasmacytoid dendritic cells or interferon type I-producing cells, methods and uses thereof.
Pereira, Filipe,, Altman, Abigail,, Fiúza Rosa, Fábio,, Pires, Cristiana,, Lund University.   +4 more
core   +1 more source

Crosspresentation: Plasmacytoid Dendritic Cells Are in the Business [PDF]

Immunity, 2007
Crosspriming and crosspresentation are performed by specialized subsets of dendritic cells. In this issue, Hoeffel et al. (2007) show that human plasmacytoid dendritic cells can crosspresent HIV-derived peptides conjugated to a lipopeptide or HIV-infected cells undergoing apoptosis.
Colonna, Marco, Cella, Marina
openaire   +2 more sources

Integrated Multiomic Analysis Reveals an EBV‐Associated MIF–SPP1+ Macrophage Axis Linking Tumor Stemness and Immune Dysfunction in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
This study maps how Epstein–Barr virus reshapes the cellular ecosystem of nasopharyngeal carcinoma. It identifies SPP1+ macrophages as partners of stemness‐associated tumor cells and dysfunctional T cells, links tumor‐derived MIF to macrophage recruitment and programming, and shows that macrophage‐derived SPP1 promotes tumorsphere formation and impairs
Guo‐Ying Liu, Shu‐Hui Lv, Shui‐Qing He, Yao‐Fei Jiang, Xing‐Si Peng, Jian‐Cong Sun, Fen He, Hai‐Yan Qin, Nian Lu, Wei‐Xin Bei, Lin‐Yu Zhao, Wan‐Qin Shen, Ze‐Yu Zhao, Lin Wang, Yan‐Qun Xiang, Wang‐Zhong Li   +15 more
wiley   +1 more source

The innate immune response to HSV-1: glycoprotein mediated activation of dendritic cells [PDF]

, 2009
Herpes Simplex Virus (HSV) – 1 also known as Human Herpes Virus (HHV) – 1 is a common infectious agent of humans which can cause a wide variety of clinical outcomes, ranging from mild mucocutaneous lesions to long term morbidity and possible mortality.
Reske, A., Reske, A
core  

Macrophages Do Not Represent the Main Cell Type in Sequestrated and Extruded Intervertebral Discs: Evidence for Their Involvement in Disc Resorption, Rather than Initiation of an Immune Response

Global Spine Journal, 2014
Introduction Herniated disc tissue have been reported to be infiltrated predominately by macrophages. 1,2 Number of macrophages in herniated disc tissue was found to be dependent on type of disc herniation.
A. Geiss, R. Sobottke, K. Stefan Delank, P. Eysel   +3 more
doaj   +1 more source

OVA-PEG-R848 nanocapsules stimulate neonatal conventional and plasmacytoid dendritic cells

Frontiers in Pediatrics, 2022
Childhood mortality represents a major issue with 5. 3 million worldwide deaths of children under 5 years of age in 2019. Approximately half of those deaths can be attributed to easily preventable, infectious diseases.
Sebastian Wirsching, Marina Machtakova, Frauke Borgans, Frauke Borgans, Leah Pretsch, Michael Fichter, Michael Fichter, Michael Fichter, Maximiliano L. Cacicedo, Héloïse Thérien-Aubin, Héloïse Thérien-Aubin, Katharina Landfester, Stephan Gehring   +12 more
doaj   +1 more source

Cumulative Reproductive‐Lactation Burdens Induce a Systemic Immunometabolic Trade‐Off Between Milk Yield and Mammary Health of Dairy Cows

Animal Research and One Health, EarlyView.
A population‐scale longitudinal transcriptomic atlas reveals how lactation stage and parity reshape systemic gene regulation in dairy cows. Multiomics‐inspired analyses uncover dynamic immune and metabolic adaptations that contribute to reproductive longevity and sustained productivity across the bovine lifespan.
Yangyang Shen, Zhenjiang An, Yingying Jiang, Zijian Huang, Kunlin Chen, Yundong Gao, Jianbin Li, Shuwen Xia, Huili Wang   +8 more
wiley   +1 more source