Results 51 to 60 of about 4,892,488 (246)

FMS-like tyrosine kinase 3 ligand treatment does not ameliorate experimental rapidly progressive glomerulonephritis. [PDF]

PLoS ONE, 2015
Fms-like tyrosine kinase 3-ligand (FL) is a growth factor that may expand dendritic cell and regulatory T cell populations. We hypothesised that FL-induced regulatory T cells would protect mice from experimental rapidly progressive glomerulonephritis. To
Joanna R Ghali, Kim M O'Sullivan, Peter J Eggenhuizen, Stephen R Holdsworth, A Richard Kitching   +4 more
doaj   +1 more source

Indispensable role of immunophenotyping in diagnosing leukemic phase of blastic plasmacytoid dendritic cell neoplasm without cutaneous manifestation

Leukemia Research Reports, 2022
Blastic plasmacytoid dendritic cell neoplasm usually presents as skin lesions. Diagnostic error occurs when it primarily presents in leukemic phase without skin involvement.
Hareem Alam, Nabiha Saeed, Anila Rashid
doaj   +1 more source

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development [PDF]

, 2011
Dendritic cells (DCs) in the thymus (tDCs) are predominantly accumulated in the medulla and contribute to the establishment of self-tolerance. However, how the medullary accumulation of tDCs is regulated and involved in self-tolerance is unclear. We show
Ishimaru, N., Hollander, G. A., Naozumi Ishimaru, Hayashi, Y., Rene de Waal Malefyt, Nitta, T., Yu Lei, Lei, Y., Jeker, L. T., Georg A. Holländer, Bosl, M. R., Yoshio Hayashi, Yousuke Takahama, Takahama, Y., Michael R. Bösl, Lukas T. Jeker, Takeshi Nitta, Nagasawa, T., Izumi Ohigashi, Ripen, A. M., Ohigashi, I., Takashi Nagasawa, Malefyt Rde, W., Adiratna Mat Ripen, Nitta, Takeshi, Ripen, Adiratna Mat, Bösl, Michael R., Lei, Yu, de Waal Malefyt, Rene, Jeker, Lukas T., Ishimaru, Naozumi, Hayashi, Yoshio, Takahama, Yousuke, Ohigashi, Izumi, Nagasawa, Takashi, Holländer, Georg A.   +35 more
core   +1 more source

Regulatory immune cells in transplantation. [PDF]

, 2012
Immune regulation is fundamental to any immune response to ensure that it is appropriate for the perceived threat to the host. Following cell and organ transplantation, it is essential to control both the innate immune response triggered by the injured ...
Bushell, Andrew, Wood, Kathryn J, Andrew Bushell, Joanna Hester, Kathryn J. Wood, Hester, Joanna   +5 more
core   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu, Jing‐Chu Hu, Ye‐Fan Hu, Wen‐Jun Li, Li Rong, Ren‐Hao Li, Yuan Yao, Lehan Hu, Xiao‐Lei Wang, Bao‐Zhong Zhang, Yicheng Lu, Shing‐Fung Chow, Canhui Su, Thomas Yau, Clive Yik‐Sham Chung, Jian‐Dong Huang   +15 more
wiley   +1 more source

The Expression of Plasmacytoid Dendritic Cells and TLR7/9-MyD88-IRAKs Pathway in Chronic Eczema Lesions

, 2023
Jiamin Wen,1 Jitian Weng,2 Wei Lu,3 Xiaohua Tao,3 Hao Cheng,4,* Yi Tang3,* 1Department of Dermatology, People’s Hospital of Tiantai County, Zhejiang University, Taizhou, People’s Republic of China; 2School of Public Health, Hangzhou Normal ...
Wen J, Lu W, Tao X, Weng J, Cheng H, Tang Y   +5 more
core  

Cutaneous blastic plasmacytoid dendritic cell neoplasm: Report of a case and review of the literature

Dermatologica Sinica, 2017
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy that usually occurs in elderly individuals and manifests with skin lesions followed by involvement of the lymph nodes, bone marrow, and peripheral blood.
Chien-yio Lin, Ming-Ying Wu, Tseng-tong Kuo, Pei-Hsuan Lu   +3 more
doaj   +1 more source

Another Heritage for Plasmacytoid Dendritic Cells [PDF]

Immunity, 2013
Plasmacytoid dendritic cell (pDC) development has been linked to that of conventional dendritic cells via a common dendritic cell precursor (CDP). In this issue of Immunity, Onai et al. (2013) outline a parallel but more effective pathway to pDCs that proceeds via a novel CDP-like precursor.
Shortman, Ken, Sathe, Priyanka
openaire   +2 more sources

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source