Results 41 to 50 of about 40,172 (208)
Leukemia Research Reports, 2022 Blastic plasmacytoid dendritic cell neoplasm usually presents as skin lesions. Diagnostic error occurs when it primarily presents in leukemic phase without skin involvement.
Hareem Alam, Nabiha Saeed, Anila Rashid
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Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
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Advanced Healthcare Materials, EarlyView.Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano +11 more
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Blastic plasmacytoid dendritic cell neoplasm [PDF]
Blood, 2012 ![Figure][1] An 81-year-old man had multiple skin lesions (brown-red plaques on the face, abdomen, and back) and asthenia. There was no hepatosplenomegaly or adenopathy. Despite normal blood count values, the peripheral smear contained blasts (7%).
Fanny, Angelot-Delettre +1 more
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Dermatologica Sinica, 2017 Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy that usually occurs in elderly individuals and manifests with skin lesions followed by involvement of the lymph nodes, bone marrow, and peripheral blood.
Chien-yio Lin +3 more
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Advanced Science, EarlyView.Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang +8 more
wiley +1 more source
Regulation of the Migration of Distinct Dendritic Cell Subsets
Frontiers in Cell and Developmental Biology, 2021 Dendritic cells (DCs), a class of antigen-presenting cells, are widely present in tissues and apparatuses of the body, and their ability to migrate is key for the initiation of immune activation and tolerogenic immune responses.
Meng Feng +5 more
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Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC
Advanced Science, EarlyView.Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang +13 more
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Crosspresentation: Plasmacytoid Dendritic Cells Are in the Business [PDF]
Immunity, 2007 Crosspriming and crosspresentation are performed by specialized subsets of dendritic cells. In this issue, Hoeffel et al. (2007) show that human plasmacytoid dendritic cells can crosspresent HIV-derived peptides conjugated to a lipopeptide or HIV-infected cells undergoing apoptosis.
Colonna, Marco, Cella, Marina
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Immunodetection of myeloid and plasmacytoid dendritic cells in mammary carcinomas of female dogs
Pesquisa Veterinária Brasileira, 2015 : Dendritic cells have attracted great interest from researchers as they may be used as targets of tumor immune evasion mechanisms. The main objective of this study was to evaluate the relationship between the dendritic cells (DCs) subpopulation in ...
Mayara C. Rosolem +7 more
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