Recombinant chymase inhibits fibrinolysis induced by endogenous plasmin in clotted human blood [PDF]
Frontiers in ImmunologyBackgroundOur group recently reported that chymase, a serine protease synthetized and released by mast cells, plays a pivotal role in thrombi stabilization in murine deep vein thrombosis (DVT) models, by interfering with the fibrinolytic properties of ...
Laurence Vincent +8 more
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Tranexamic acid impairs plasmin generation on human mesenchymal stem cells and derived membrane microvesicles, halting pericellular proteolysis [PDF]
Frontiers in MedicineIntroductionMesenchymal stem cells (MSCs) participate in the dynamic remodeling of the extracellular matrix during wound healing, natural bleeding processes or cancer progression.
Ramy Abou Rjeily +6 more
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Acute obstetric coagulopathy is associated with excess plasmin generation and proteolysis of fibrinogen and factor V [PDF]
Blood Advances: Hemostatic impairment may exacerbate postpartum hemorrhage (PPH). Previously, we described a distinct coagulopathy, associated with multiple causes of PPH including placental abruption and amniotic fluid embolus, termed acute obstetric coagulopathy ...
Peter W. Collins +8 more
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Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity [PDF]
, 2009 Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
AG Barbour +59 more
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Recent Advances in Milk Plasmin and Factors Affecting Its Activity [PDF]
Shipin Kexue, 2023 Plasmin is an important factor affecting the shelf-life quality of milk products, and its hydrolytic activity is regulated by many factors, such as activators, inhibitors, and activator inhibitors.
YANG Jinhui, QIAN Wentao, LI Hongliang, WANG Menghui, ZHAO Jingru, REN Xiaomin
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Gender affects skin wound healing in plasminogen deficient mice. [PDF]
PLoS ONE, 2013 The fibrinolytic activity of plasmin plays a fundamental role in resolution of blood clots and clearance of extravascular deposited fibrin in damaged tissues.
Birgitte Rønø +3 more
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Chemosensors, 2022 Plasmin protease plays an important role in many processes in living systems, including milk. Monitoring plasmin activity is important for control of the nutritional quality of milk and other dairy products.
Sandro Spagnolo +3 more
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Unexpected timely fracture union in matrix metalloproteinase 9 deficient mice. [PDF]
PLoS ONE, 2018 Immediately following a fracture, a fibrin laden hematoma is formed to prevent bleeding and infection. Subsequently, the organized removal of fibrin, via the protease plasmin, is essential to permit fracture repair through angiogenesis and ossification ...
Masato Yuasa +10 more
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Induction of brain microvascular endothelial cell urokinase expression by Cryptococcus neoformans facilitates blood-brain barrier invasion. [PDF]
PLoS ONE, 2012 The invasive ability of the blood-borne fungal pathogen Cryptococcus neoformans can be enhanced through interactions with host plasma components, such as plasminogen.
Jamal Stie, Deborah Fox
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Plasmin plays an essential role in amplification of psoriasiform skin inflammation in mice. [PDF]
PLoS ONE, 2011 BACKGROUND:Although increased levels of plasminogen activators have been found in psoriatic lesions, the role of plasmin converted from plasminogen by plasminogen activators in pathogenesis of psoriasis has not been investigated.
Qun Li +8 more
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