Results 1 to 10 of about 81,533 (325)

Plasmin and Plasminogen System in the Tumor Microenvironment: Implications for Cancer Diagnosis, Prognosis, and Therapy

Cancers, 2021
Simple Summary In this review, we present a detailed discussion of how the plasminogen-activation system is utilized by tumor cells in their unrelenting attack on the tissues surrounding them.
Victoria A Miller
exaly   +2 more sources

Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility

Physiological Reviews, 2020
Patients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, COPD, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons.
Hong-Long Ji, Sadis Matalon, Michael A Matthay   +2 more
exaly   +2 more sources

Anti-protease Treatments Targeting Plasmin(ogen) and Neutrophil Elastase May Be Beneficial in Fighting COVID-19

Physiological Reviews, 2020
To the Editor: Ji et al. (6) have convincingly shown that elevated plasmin(ogen) is a common risk factor in COVID-19 susceptibility. They highlighted the clinical relevance of plasmin(ogen) in patients who are susceptible to SARS-CoV-2 because of ...
Alain R Thierry
exaly   +2 more sources

Fibrinolysis and COVID‐19: A plasmin paradox

Journal of Thrombosis and Haemostasis, 2020
The COVID‐19 pandemic has provided many challenges in the field of thrombosis and hemostasis. Among these is a novel form of coagulopathy that includes exceptionally high levels of D‐dimer.
Robert L Medcalf, Charithani B Keragala
exaly   +2 more sources

Glaucoma is associated with plasmin proteolytic activation mediated through oxidative inactivation of neuroserpin

Scientific Reports, 2017
Neuroserpin is a serine protease inhibitor that regulates the activity of plasmin and its activators in the neuronal tissues. This study provides novel evidence of regulatory effect of the neuroserpin on plasmin proteolytic activity in the retina in ...
Vivek Gupta, Mehdi Mirzaei, Veer Bala Gupta, Nitin Chitranshi, Yogita Dheer, Roshana Vander Wall, Mojdeh Abbasi, Yuyi You, Roger Chung, Stuart Graham   +9 more
doaj   +2 more sources

X-ray crystal structure of plasmin with tranexamic acid–derived active site inhibitors

Blood Advances, 2017
: The zymogen protease plasminogen and its active form plasmin perform key roles in blood clot dissolution, tissue remodeling, cell migration, and bacterial pathogenesis.
Ruby H.P. Law, Guojie Wu, Eleanor W.W. Leung, Koushi Hidaka, Adam J. Quek, Tom T. Caradoc-Davies, Devadharshini Jeevarajah, Paul J. Conroy, Nigel M. Kirby, Raymond S. Norton, Yuko Tsuda, James C. Whisstock   +11 more
doaj   +2 more sources

Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin. [PDF]

PLoS ONE, 2015
Removal of dead cells in the absence of concomitant immune stimulation is essential for tissue homeostasis. We recently identified an injury-induced protein misfolding event that orchestrates the plasmin-dependent proteolytic degradation of necrotic ...
Rachael J Borg, Andre L Samson, Amanda E-L Au, Anja Scholzen, Martina Fuchsberger, Ying Y Kong, Roxann Freeman, Nicole A Mifsud, Magdalena Plebanski, Robert L Medcalf   +9 more
doaj   +2 more sources

Tranexamic acid impairs plasmin generation on human mesenchymal stem cells and derived membrane microvesicles, halting pericellular proteolysis [PDF]

Frontiers in Medicine
IntroductionMesenchymal stem cells (MSCs) participate in the dynamic remodeling of the extracellular matrix during wound healing, natural bleeding processes or cancer progression.
Ramy Abou Rjeily, Christina Mrad, Fatiha Z. El-Ghazouani, Florence Toti, Audrey Cras, Audrey Cras, Eduardo Angles-Cano   +6 more
doaj   +2 more sources

Recombinant chymase inhibits fibrinolysis induced by endogenous plasmin in clotted human blood [PDF]

Frontiers in Immunology
BackgroundOur group recently reported that chymase, a serine protease synthetized and released by mast cells, plays a pivotal role in thrombi stabilization in murine deep vein thrombosis (DVT) models, by interfering with the fibrinolytic properties of ...
Laurence Vincent, Catherine Lapointe, Patrick P. McDonald, Christos Rammos, Tienush Rassaf, Maria Köllnberger, Hanna Tinel, Stefan Heitmeier, Pedro D’Orléans-Juste   +8 more
doaj   +2 more sources

Acute obstetric coagulopathy is associated with excess plasmin generation and proteolysis of fibrinogen and factor V [PDF]

Blood Advances
: Hemostatic impairment may exacerbate postpartum hemorrhage (PPH). Previously, we described a distinct coagulopathy, associated with multiple causes of PPH including placental abruption and amniotic fluid embolus, termed acute obstetric coagulopathy ...
Peter W. Collins, Claire S. Whyte, Lucy de Lloyd, Anuj Narwal, Sarah F. Bell, Nicholas Gill, Rachel E. Collis, Peter V. Jenkins, Nicola J. Mutch   +8 more
doaj   +2 more sources