Results 1 to 10 of about 63,325 (266)

Increased Mosquito Midgut Infection by Dengue Virus Recruitment of Plasmin Is Blocked by an Endogenous Kazal-type Inhibitor

iScience, 2019
Summary: Dengue symptoms include alteration of blood coagulation and fibrinolysis, causing severe hemorrhage and death. Here, we demonstrate that higher concentration of plasmin, the human fibrinolytic factor, in blood meal enhances dengue virus (DENV ...
Karthik Ramesh, Varsha A. Walvekar, Benjamin Wong, Ahmed Mahmoud Mohammed Sayed, Dorothée Missé, R. Manjunatha Kini, Yu Keung Mok, Julien Pompon   +7 more
doaj  

The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

eLife, 2020
Osteocalcin (OCN) is an osteoblast-derived hormone with pleiotropic physiological functions. Like many peptide hormones, OCN is subjected to post-translational modifications (PTMs) which control its activity.
Omar Al Rifai, Catherine Julien, Julie Lacombe, Denis Faubert, Erandi Lira-Navarrete, Yoshiki Narimatsu, Henrik Clausen, Mathieu Ferron   +7 more
doaj   +1 more source

Recent advances in cardiovascular medicines : thrombolytics [PDF]

, 1990
Thrombolytic therapy represents a major advance in reducing mortality following myocardial infarction. Pharmacists must be aware of the principles and problems of thrombolysis and the extant large studies conducted in hospitals and in the community. This
Felice, Herbert, Gatt, Marise, Harron, Dean   +2 more
core  

Does plasmin have anticoagulant activity?

Vascular Health and Risk Management, 2010
Jane Hoover-PlowJoseph J Jacobs Center for Thrombosis and Vascular Biology, Departments of Cardiovascular Medicine and Molecular Cardiology, Lerner Research Institute Cleveland Clinic, Ohio, USAAbstract: The coagulation and fibrinolytic pathways regulate
Jane Hoover-Plow
doaj  

Aspects of proteolysis in cheese : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Food Technology at Massey University [PDF]

, 1994
The purpose of the present study was to elaborate methods for the detailed examination of proteolysis pathways in cheese (reviewed in Chapter 1) and to demonstrate their usefulness.
Coker, Christina June
core  

Plasmin reduces fibronectin deposition by mesangial cells in a protease-activated receptor-1 independent manner

Biochemistry and Biophysics Reports, 2017
Background: Protease-activated receptor-1 (PAR-1) potentiates diabetic nephropathy (DN) as evident from reduced kidney injury in diabetic PAR-1 deficient mice. Although thrombin is the prototypical PAR-1 agonist, anticoagulant treatment does not limit DN
Maaike Waasdorp, JanWillem Duitman, C. Arnold Spek   +2 more
doaj   +1 more source

Insulin-like growth factor binding proteins initiate cell death and extracellular matrix remodeling in the mammary gland [PDF]

, 2005
We have demonstrated that insulin-like growth factor binding protein-5 (IGFBP-5) production by mammary epithelial cells increases dramatically during forced involution of the mammary gland in rats, mice and pigs.
Accorsi, Akers, Allan, Baldi, Barber, Barber, Baumrucker, Baxter, Blatchford, Boutinaud, Boutinaud, Boyle, Bramani, Brisken, Butt, Capuco, Chan, Chan, Chokkalingam, Cohick, Davis, Dupont, Farrelly, Flint, Flint, Flint, Forsyth, Guenette, Hadsell, Hovey, Jaggi, Knight, Knight, Liux, Ma, Madon, Marshman, McGrath, Moorehead, Nam, Neuenschwander, Peri, Phillips, Pollak, Quarrie, Rosfjord, Sejrsen, Shand, Sheffield, Song, Song, Strange, Talhouk, Tonner, Tonner, Tonner, Travers, Wilde, Wilde, Wilde, Wolk   +60 more
core   +1 more source

Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines. [PDF]

, 2019
BACKGROUND:Astrocytes contribute to the crosstalk that generates chronic neuro-inflammation in neurological diseases; however, compared with microglia, astrocytes respond to a more limited continuum of innate immune system stimulants.
Azmoon, Pardis, Banki, Michael A, Gonias, Steven L, Kounnas, Maria Z, Mantuano, Elisabetta, Marchese, Cinzia, Pontecorvi, Paola, Zalfa, Cristina, Zampieri, Carlotta   +8 more
core   +1 more source

Efficacy and safety of argatroban combined with plasmin in the treatment of acute cerebral infarction

Zhongguo linchuang yanjiu
Objective To observe the effects of combined application of argatroban and plasmin on the degree of neurological function deficit and neutrophil (NEUT) count in patients with acute cerebral infarction (ACI) and their safety.
HU Tao*, CAO Hong
doaj   +1 more source

Evaluation of Serum Fibrinogen, Plasminogen, α2-Anti-Plasmin, and Plasminogen Activator Inhibitor Levels (PAI) and Their Correlation with Presence of Retinopathy in Patients with Type 1 DM

Journal of Diabetes Research, 2014
Background. Diabetic retinopathy (DR) is the leading cause of blindness in the world. Retinopathy can still progress despite optimal metabolic control.
Sefika Burcak Polat, Nagihan Ugurlu, Fatma Yulek, Huseyin Simavli, Reyhan Ersoy, Bekir Cakir, Ozcan Erel   +6 more
doaj   +1 more source