Results 21 to 30 of about 30,314 (207)

Activation of Pro-uPA Is Critical for Initial Escape from the Primary Tumor and Hematogenous Dissemination of Human Carcinoma Cells

Neoplasia: An International Journal for Oncology Research, 2011
Urokinase-type plasminogen activator (uPA) and plasmin have long been implicated in cancer progression. However, the precise contributions of the uPA/plasmin system to specific steps involved in cancer cell dissemination have not been fully established ...
Erin M. Bekes, Elena I. Deryugina, Tatyana A. Kupriyanova, Ewa Zajac, Kenneth A. Botkjaer, Peter A. Andreasen, James P. Quigley   +6 more
doaj   +1 more source

Markers of thrombogenesis and fibrinolysis and their relation to inflammation and endothelial activation in patients with idiopathic pulmonary arterial hypertension.

PLoS ONE, 2013
BackgroundChronic anticoagulation is a standard of care in idiopathic pulmonary arterial hypertension (IPAH). However, hemostatic abnormalities in this disease remain poorly understood.
Grzegorz Kopeć, Deddo Moertl, Sabine Steiner, Ewa Stępień, Tomasz Mikołajczyk, Jakub Podolec, Marcin Waligóra, Jakub Stępniewski, Lidia Tomkiewicz-Pająk, Tomasz Guzik, Piotr Podolec   +10 more
doaj   +1 more source

On the Mechanism of Thrombolysis by Plasmin [PDF]

Circulation Research, 1962
I 131 -labeled purified human fibrin clots were introduced into the circulation of dogs at various time intervals after an infusion of human plasmin. One hour later, the clots were removed and incubated in saline at 37 C.
C M, AMBRUS, N, BACK, J L, AMBRUS
openaire   +2 more sources

X-ray crystal structure of plasmin with tranexamic acid–derived active site inhibitors

Blood Advances, 2017
: The zymogen protease plasminogen and its active form plasmin perform key roles in blood clot dissolution, tissue remodeling, cell migration, and bacterial pathogenesis.
Ruby H.P. Law, Guojie Wu, Eleanor W.W. Leung, Koushi Hidaka, Adam J. Quek, Tom T. Caradoc-Davies, Devadharshini Jeevarajah, Paul J. Conroy, Nigel M. Kirby, Raymond S. Norton, Yuko Tsuda, James C. Whisstock   +11 more
doaj   +1 more source

The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

eLife, 2020
Osteocalcin (OCN) is an osteoblast-derived hormone with pleiotropic physiological functions. Like many peptide hormones, OCN is subjected to post-translational modifications (PTMs) which control its activity.
Omar Al Rifai, Catherine Julien, Julie Lacombe, Denis Faubert, Erandi Lira-Navarrete, Yoshiki Narimatsu, Henrik Clausen, Mathieu Ferron   +7 more
doaj   +1 more source

Enhanced thrombin and plasmin generation profiles in alpha-2-antiplasmin–deficient patients: Data from the Rare Bleeding disorders in the Netherlands study

Research and Practice in Thrombosis and Haemostasis
Background: α2-Antiplasmin (A2AP) deficiency is a rare and often unidentified disorder characterized by increased fibrinolysis and subsequent bleeding. Global hemostasis assays may increase insight into the altered coagulation and fibrinolysis in these ...
Bauke Haisma, Sanna R. Rijpma, Marjon H. Cnossen, Paul L. den Exter, Ilmar C. Kruis, Karina Meijer, Laurens Nieuwenhuizen, Nick van Es, Roger E.G. Schutgens, Nicole M.A. Blijlevens, Waander L. van Heerde, Saskia E.M. Schols   +11 more
doaj   +1 more source

A novel mechanism controlling the growth of hemostatic thrombi [PDF]

The Ukrainian Biochemical Journal, 2013
Current knowledge of the mechanisms of blood coagulation does not provide an answer to one pivotal question: why is, in contrast to a pathological thrombus, the growth of normal hemostatic clot after blood vessel injury suddenly terminated?
V. K. Lishko, I. S. Yermolenko, N. P. Podolnikova, T. P. Ugarova   +3 more
doaj   +1 more source

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Glaucoma is associated with plasmin proteolytic activation mediated through oxidative inactivation of neuroserpin

Scientific Reports, 2017
Neuroserpin is a serine protease inhibitor that regulates the activity of plasmin and its activators in the neuronal tissues. This study provides novel evidence of regulatory effect of the neuroserpin on plasmin proteolytic activity in the retina in ...
Vivek Gupta, Mehdi Mirzaei, Veer Bala Gupta, Nitin Chitranshi, Yogita Dheer, Roshana Vander Wall, Mojdeh Abbasi, Yuyi You, Roger Chung, Stuart Graham   +9 more
doaj   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source