Results 31 to 40 of about 30,314 (207)
POEMS Syndrome: 2026 Update on Diagnosis, Risk‐Stratification, and Management
American Journal of Hematology, EarlyView.ABSTRACT Disease Overview POEMS syndrome is a life‐threatening syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease.
Angela Dispenzieri
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.We report a novel embolus‐induced PE rat model prepared via the inferior vena cava under ultrasound guidance. The embolus employed featured a tubular plastic casing filled with thrombus. By minimizing the contact surface between plasmin and thrombus, it effectively restrains the elevated plasmin activity in rats.
Huide Ma +7 more
wiley +1 more source
Effects of Plasmin on von Willebrand Factor and Platelets: A Narrative Review
TH Open, 2018 Plasmin is the major fibrinolytic protease responsible for dissolving thrombi by cleavage of its primary substrate fibrin. In addition, emerging evidence points to other roles of plasmin: (1) as a back-up for ADAMTS13 in proteolysis of ultra-large von ...
Lisa N. van der Vorm +3 more
doaj +1 more source
Reprogramming macrophages by plasmin [PDF]
Blood, 2017 Resolution of inflammation is a key physiological process regulated at different levels, and failure to achieve resolution may result in chronic inflammation. In this issue of Blood , Sugimoto et al reveal the function of the plasmin system in resolving inflammation by inducing macrophage polarization toward M2 and proresolving phenotypes.
openaire +2 more sources
Biotechnology and Bioengineering, EarlyView.ABSTRACT Alpha‐1‐antitrypsin (A1AT) is a multifunctional, clinically important, high‐value therapeutic glycoprotein that can be used for the treatment of many diseases, such as A1AT deficiency, diabetes, graft‐versus‐host disease, cystic fibrosis, and various viral infections. Currently, the only U.S. food and drug administration‐approved treatment for
Frances Rocamora +12 more
wiley +1 more source
Plasmin: indigenous milk proteinase
Mljekarstvo, 2002 The most important characteristic of plasmin, as significant indigenous milk proteinase, its concentration, concentration measuring procedure and activity of plasmin are described.
Samir Kalit +2 more
doaj
Establishing the Inhibition of the Serine Protease Plasmin as a Skin Anti-Aging Pathway
CosmeticsPlasmin is a serine protease induced by UV-irradiation in skin that contributes to inflammation. We showed that plasmin is upregulated in photo-exposed facial skin and that this correlates with increased transepidermal water loss (TEWL). Plasmin activity
Remo Campiche +4 more
doaj +1 more source
BioTechniques, 1996 MatrigelTM, a basement membrane (BM) extract of the Engelbreth-Holm-Swarm (EHS) sarcoma, used in tumor invasion assays, was found to contain plasminogen.
A.R. Farina +6 more
doaj +1 more source
The ANXA2/S100A10 Complex—Regulation of the Oncogenic Plasminogen Receptor
Biomolecules, 2021 The generation of the serine protease plasmin is initiated by the binding of its zymogenic precursor, plasminogen, to cell surface receptors.
Alamelu G. Bharadwaj +2 more
doaj +1 more source
Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration
BMEMat, EarlyView.The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang +13 more
wiley +1 more source