Results 31 to 40 of about 39,772 (244)

On the Mechanism of Thrombolysis by Plasmin [PDF]

Circulation Research, 1962
I 131 -labeled purified human fibrin clots were introduced into the circulation of dogs at various time intervals after an infusion of human plasmin. One hour later, the clots were removed and incubated in saline at 37 C.
C M, AMBRUS, N, BACK, J L, AMBRUS
openaire   +2 more sources

X-ray crystal structure of plasmin with tranexamic acid–derived active site inhibitors

Blood Advances, 2017
: The zymogen protease plasminogen and its active form plasmin perform key roles in blood clot dissolution, tissue remodeling, cell migration, and bacterial pathogenesis.
Ruby H.P. Law, Guojie Wu, Eleanor W.W. Leung, Koushi Hidaka, Adam J. Quek, Tom T. Caradoc-Davies, Devadharshini Jeevarajah, Paul J. Conroy, Nigel M. Kirby, Raymond S. Norton, Yuko Tsuda, James C. Whisstock   +11 more
doaj   +1 more source

Enhanced thrombin and plasmin generation profiles in alpha-2-antiplasmin–deficient patients: Data from the Rare Bleeding disorders in the Netherlands study

Research and Practice in Thrombosis and Haemostasis
Background: α2-Antiplasmin (A2AP) deficiency is a rare and often unidentified disorder characterized by increased fibrinolysis and subsequent bleeding. Global hemostasis assays may increase insight into the altered coagulation and fibrinolysis in these ...
Bauke Haisma, Sanna R. Rijpma, Marjon H. Cnossen, Paul L. den Exter, Ilmar C. Kruis, Karina Meijer, Laurens Nieuwenhuizen, Nick van Es, Roger E.G. Schutgens, Nicole M.A. Blijlevens, Waander L. van Heerde, Saskia E.M. Schols   +11 more
doaj   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

AvKTI forms complexes with plasmin.

, 2013
Western blot analysis of the formation of plasmin-AvKTI complex via native gel electrophoresis was performed. Three micrograms of plasmin were incubated with 1 µg of AvKTI, and the samples (plasmin, AvKTI, or plasmin-AvKTI mixture) were resolved on a 10%
Hyung Joo Yoon (249514), Bo Yeon Kim (164272), Feng Ming Zou (290690), Yeon Ho Je (146274), Kwang Sik Lee (249513), Jianhong Li (290691), Hu Wan (290689), Byung Rae Jin (249519)   +7 more
core   +1 more source

Glaucoma is associated with plasmin proteolytic activation mediated through oxidative inactivation of neuroserpin

Scientific Reports, 2017
Neuroserpin is a serine protease inhibitor that regulates the activity of plasmin and its activators in the neuronal tissues. This study provides novel evidence of regulatory effect of the neuroserpin on plasmin proteolytic activity in the retina in ...
Vivek Gupta, Mehdi Mirzaei, Veer Bala Gupta, Nitin Chitranshi, Yogita Dheer, Roshana Vander Wall, Mojdeh Abbasi, Yuyi You, Roger Chung, Stuart Graham   +9 more
doaj   +1 more source

Plasmin degrades C3a.

, 2013
(A) C3a was completely degraded by plasmin; plasminogen had a weak degrading effect. S. aureus was incubated with C3a in the presence of plasmin (PLG+SAK) (lane 4) or plasminogen alone (lane 6). The supernatants were analyzed by SDS-PAGE and Western blot
Tina K. Koch (303277), Jean van den Elsen (268290), Peter Kraiczy (36173), Christine Skerka (105424), Michael Reuter (268288), Sascha Böhm (303280), Peter F. Zipfel (105431), Diana Barthel (303279)   +7 more
core   +1 more source

Effect of the protease plasmin on C. elegans hyperactive DEG/ENaC channels MEC-4(d) and UNC-8(d)

microPublication Biology, 2021
C. elegans MEC-4 and UNC-8 belong to the DEG/ENaC family of voltage-independent Na+ channels and have been implicated in mechanosensation and synaptic remodeling.
Christina K. Johnson, David D. Miller, Laura Bianchi   +2 more
doaj   +1 more source

Causal correlations between inflammatory proteins and heart failure: A two‐sample Mendelian randomization analysis

ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.
Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu, Gui‐Qin Liu, Ya‐Ping Peng, Li‐Ling Zhang, Xian‐Jin Wang, Liang‐Chuan Chen, Yuan‐Xi Zheng, Xue‐Jun Xiang, Rui Qiao, Xian‐He Lin   +9 more
wiley   +1 more source

Natural and engineered plasmin inhibitors : applications and design strategies

, 2012
Plasmin is the primary enzyme responsible for dissolution of fibrin in the circulatory system. Plasminogen, the zymogen of plasmin is expressed ubiquitously in the human body [1], with the predominant source being the liver [2, 3].
Joakim E. Swedberg, Swedberg, Joakim E., Harris, Jonathan M., Jonathan M. Harris   +3 more
core   +1 more source