Results 91 to 100 of about 81,533 (325)

HGF modulates actin cytoskeleton remodeling and contraction in testicular myoid cells [PDF]

, 2015
The presence of the HGF/Met system in the testicular myoid cells was first discovered by our group. However, the physiological role of this pathway remains poorly understood. We previously reported that HGF increases uPA secretion and TGF-β activation in
Angela, Catizone, Caruso, Maria, Galdieri, Michela, Ricci, Giulia, Rita, Canipari, Scheri, Katia Corano, Virginia, Di Paolo   +6 more
core   +1 more source

Considerations and challenges of septic arthritis and osteomyelitis

Equine Veterinary Education, EarlyView.
Summary Septic arthritis remains a common orthopaedic condition in both human and veterinary medicine which can cause serious morbidity and pose considerable challenges for clinical management. The majority of the published clinical research in humans and veterinary species has been focused on the diagnosis, treatment, prevention and outcome of this ...
J. B. Engiles, H. L. Stewart
wiley   +1 more source

Neutrophil Extracellular Traps Are Not Linked to Decompensation, ACLF, or Death in Clinically Stable Patients With ACLD. [PDF]

Liver Int
ABSTRACT Background and Aims Neutrophil extracellular traps (NETs) are part of the body's innate immune response. In animal models, NETs aggravated liver injury and promoted disease progression/portal hypertension by the formation of (micro)thrombi leading to parenchymal extinction.
Balcar L, Scheiner B, Simbrunner B, Jachs M, Hartl L, Semmler G, Silvester Hofer B, Schwarz M, Dominik N, Adelmeijer J, Stättermayer AF, Pinter M, Trauner M, Quehenberger P, Francés R, Reiberger T, Lisman T, Mandorfer M.   +17 more
europepmc   +2 more sources

Activation of the Urokinase Plasminogen Activator/Urokinase Plasminogen Activator Receptor System in Periodontitis: A Case–Control Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Introduction The plasminogen activating (PA) system has a multitude of functions such as wound healing, proteolytic activity, collagen degradation and cell growth, and the role of the urokinase plasminogen activator/urokinase plasminogen activator receptor (uPA/uPAR) system has been studied in many disease states.
Ahmed Khudhur, Christopher Dowson, Susan M. Bissett, Rachel van de Merwe, John J. Taylor, Philip M. Preshaw, Katrin M. Jaedicke   +6 more
wiley   +1 more source

Using antifibrinolytics to tackle neuroinflammation

Neural Regeneration Research, 2020
Plasmin is generally known as a promotor of inflammation. Recent advancement suggests that it has a complex role as immunity modulator. Pharmacological inhibition of plasmin production and activity has been proven to improve neurological outcomes in ...
Stanimir Atsev, Nikola Tomov
doaj   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

INACTIVATION OF ACTH BY HUMAN PLASMIN SYSTEM AND EFFECT OF PLASMIN INHIBITORS

Endocrinologia Japonica, 1964
The inactivation of ACTH by human plasma or euglobulin fraction activated by streptokinase in vitro was studied.The assay of ACTH was carried out by the method of adrenal ascorbic acid depletion of non-hypophysectomized rat treated withprednisolone 4 hrs.
Yasuhiko Morimoto, Yuichi Yamamura, Kazuyuki Takeuchi, Yositsugu Asanuma, Taizo Uemura, Akira Kumagai   +5 more
openaire   +4 more sources

A Spider-Derived Kunitz-Type Serine Protease Inhibitor That Acts as a Plasmin Inhibitor and an Elastase Inhibitor

PLoS ONE, 2013
Kunitz-type serine protease inhibitors are involved in various physiological processes, such as ion channel blocking, blood coagulation, fibrinolysis, and inflammation.
Hu Wan, K. Lee, Bo Yeon Kim, Fengming Zou, H. Yoon, Y. Je, Jianhong Li, B. Jin   +7 more
semanticscholar   +1 more source

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source

Advances in Analysis of Milk Proteases Activity at Surfaces and in a Volume by Acoustic Methods

Sensors, 2020
This review is focused on the application of surface and volume-sensitive acoustic methods for the detection of milk proteases such as trypsin and plasmin. While trypsin is an important protein of human milk, plasmin is a protease that plays an important
Mark Dizon, Marek Tatarko, Tibor Hianik
doaj   +1 more source