Results 91 to 100 of about 63,325 (266)

Systemic effects of tissue plasminogen activator-associated fibrinolysis and its relation to thrombin generation in orthotopic liver transplantation [PDF]

, 1989
Orthotopic liver transplantation is frequently associated with hyperfibrinolysis, the origin and clinical relevance of which is largely unknown. In 20 orthotopic liver transplantations, we studied the occurrence and systemic effects of hyperfibrinolysis.
Bontempo, FA, Kang, YG, Knot, EAR, Lewis, JH, Porte, RJ, Starzl, TE   +5 more
core   +1 more source

Injectable and Sprayable Thermoresponsive Hydrogel with Fouling‐Resistance as an Effective Barrier to Prevent Postoperative Cardiac Adhesions

Advanced Science, Volume 12, Issue 23, June 20, 2025.
Postoperative cardiac adhesions lead to numerous difficulties in reoperation procedures. Here, a thermo‐responsive in situ formed hydrogel is shown to can reliably cover the wounds after a convenient spraying or injection and significantly reduce adhesion formation in primary and recurrent cardiac injury adhesion models.
Kun Shi, Tao Li, Xulin Hu, Wen Chen, Yan Yu, Zhongwu Bei, Liping Yuan, Qi Tong, Jiafeng Liu, Qiang Fan, Yongjun Qian, Zhiyong Qian   +11 more
wiley   +1 more source

The Effect of Postoperative Antithrombin Supplementation on the Inflammatory and Coagulation Status of a Surgically Treated Patient With a Malignant Tumor in the Small Pelvis—Case Series

Cancer Reports, Volume 8, Issue 6, June 2025.
ABSTRACT Introduction Antithrombin has the function of a natural anticoagulant. It is the main component of the inhibitory anticoagulant system, which, under physiological conditions, opposes the procoagulant mechanisms of hemostasis, preventing the occurrence of a hypercoagulable state, the development of thrombosis, and thromboembolic complications ...
Ranko Lazović, Ognjenka Šarenac
wiley   +1 more source

Therapeutic potential of the annexin A family in atherosclerosis

Clinical and Translational Discovery, Volume 5, Issue 3, June 2025.
Annexin A (AnxA) family members, including AnxA1, AnxA2, AnxA5, AnxA6, AnxA7 and AnxA8, play diverse roles in the development and progression of atherosclerosis and present promising therapeutic targets for its treatment. Abstract Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality and morbidity worldwide despite ...
Suha Jarad, Da‐wei Zhang
wiley   +1 more source

Numerical study of cancer cell invasion dynamics using adaptive mesh refinement: the urokinase model

, 2014
In the present work we investigate the chemotactically and proteolytically driven tissue invasion by cancer cells. The model employed is a system of advection-reaction-diffusion equations that features the role of the serine protease urokinase-type ...
Hellmann, Nadja, Katuchova, Jana, Kolbe, Niklas, Lukacova-Medvidova, Maria, Sfakianakis, Nikolaos   +4 more
core  

Transcriptional regulation of the urokinase receptor (u-PAR) - A central molecule of invasion and metastasis [PDF]

, 2003
The phenomenon of tumor-associated proteolysis has been acknowledged as a decisive step in the progression of cancer. This short review focuses on the urokinase receptor (u-PAR), a central molecule involved in tumor-associated invasion and metastasis ...
Behrendt N., Bianchi E., Borglum A.D., Boyd D., Chapman H.A., Conese M., Cubellis M.V., Duffy M.J., Duffy M.J., Ellis V., Hollas W., Kariko K., Kook Y.H., Lakka S.S., Langer D.J., Leupold J.H., Lund L.R., Means A.L., Min H.Y., Mohanam S., Nekarda H., Pedersen H., Pyke C., Pyke C., Quattrone A., Resnati M., Roldan A., Schewe D., Shetty S., Soravia E., Suh T., Xue W.   +31 more
core   +1 more source

New horizons in the pharmacological management of venous thromboembolism

HemaSphere, Volume 9, Issue 6, June 2025.
Abstract Many patients suffer from venous thromboembolism (VTE) and its consequences. Despite substantial advancements with the introduction of direct oral anticoagulants (DOACs), patients and clinicians still encounter challenges in the acute and long‐term management of VTE, such as recurrent events, anticoagulant‐related bleeding complications, and ...
Andreas Verstraete, Quentin Van Thillo, Thomas Vanassche, Peter Verhamme   +3 more
wiley   +1 more source

Enolase and 16.5‐kDa Tegument‐Associated Protein in Fasciola hepatica Extracellular Vesicles: Clues to Their Role in Pathogenesis

Journal of Extracellular Biology, Volume 4, Issue 6, June 2025.
Recombinant enolase and 16.5 tegumentary proteins from F. hepatica EVs may influence the progression of fibrosis, altering cell growth, proteomic profiles, and EVs secretion in macrophages, hepatic stellate cells (HSCs) and hepatocytes. r‐Fhenolase reduced fibrosis markers in HSCs and exhibited anti‐inflammatory properties in macrophages, and r‐Fh16 ...
Aránzazu González‐Arce, Christian M. Sánchez‐López, Liz F. Sánchez‐Palencia, Antonio Marcilla, Dolores Bernal   +4 more
wiley   +1 more source

X-ray crystal structure of plasmin with tranexamic acid–derived active site inhibitors

Blood Advances, 2017
: The zymogen protease plasminogen and its active form plasmin perform key roles in blood clot dissolution, tissue remodeling, cell migration, and bacterial pathogenesis.
Ruby H.P. Law, Guojie Wu, Eleanor W.W. Leung, Koushi Hidaka, Adam J. Quek, Tom T. Caradoc-Davies, Devadharshini Jeevarajah, Paul J. Conroy, Nigel M. Kirby, Raymond S. Norton, Yuko Tsuda, James C. Whisstock   +11 more
doaj  

Ocriplasmin in the treatment of vitreomacular traction in a patient with central retinal vein occlusion. a case report [PDF]

, 2018
Aim: To investigate the efficacy of intravitreal injection of ocriplasmin (JETREA®) in the treat-ment of vitreomacular traction (VMT). Materials and Methods: An 81-year-old man with VMT associated with central retinal vein occlusion in his left eye, was ...
Antonio Esposito, Raffaele, Mannino, Giuseppe, Rosati, Alessandra, Scuderi, Gianluca   +3 more
core   +2 more sources