Results 11 to 20 of about 65,619 (298)
Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin
Computational and Structural Biotechnology Journal, 2022 Cardio- and cerebrovascular diseases are leading causes of death and disability, resulting in one of the highest socio-economic burdens of any disease type.
Dmitri Nikitin +12 more
doaj +1 more source
Plasmin drives burn-induced systemic inflammatory response syndrome
JCI Insight, 2021 Severe injuries, such as burns, provoke a systemic inflammatory response syndrome (SIRS) that imposes pathology on all organs. Simultaneously, severe injury also elicits activation of the fibrinolytic protease plasmin. While the principal adverse outcome
Breanne H. Y. Gibson +8 more
doaj +1 more source
Effects of stage of lactation and time of year on plasmin-derived proteolytic activity in bovine milk in New Zealand [PDF]
, 2002 The objective of this study was to determine the effects of stage of lactation (SOL) and time of year on plasmin-derived proteolytic activity in the milk of pasture-fed dairy cows in New Zealand. Four herds of 20 Friesian cows were used, one herd calving
Auldist, Martin J. +4 more
core +2 more sources
Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature. [PDF]
PLoS ONE, 2011 Clinical trials revealed beneficial effects of the broad-spectrum serine protease inhibitor aprotinin on the prevention of ischemia-reperfusion (I/R) injury. The underlying mechanisms remained largely unclear.
Christoph A Reichel +7 more
doaj +1 more source
Lens subluxation after plasmin and SF6 injections in rabbit eyes. [PDF]
PLoS ONE, 2014 To investigate the rate of lens subluxation following plasmin and/or SF6 injections in eyes, and whether a subsequent elevated level of vascular endothelial growth factor (VEGF) and vitreous tap would aggravate subluxation.Four groups of rabbits were ...
Wei-Chi Wu +8 more
doaj +1 more source
iScience, 2019 Summary: Dengue symptoms include alteration of blood coagulation and fibrinolysis, causing severe hemorrhage and death. Here, we demonstrate that higher concentration of plasmin, the human fibrinolytic factor, in blood meal enhances dengue virus (DENV ...
Karthik Ramesh +7 more
doaj +1 more source
Group B Streptococcus hijacks the host plasminogen system to promote brain endothelial cell invasion. [PDF]
PLoS ONE, 2013 Group B Streptococcus (GBS) is the leading cause of meningitis in neonates. We have previously shown that plasminogen, once recruited to the GBS cell surface and converted into plasmin by host-derived activators, leads to an enhancement of bacterial ...
Vanessa Magalhães +7 more
doaj +1 more source
Plasmin Regulation through Allosteric, Sulfated, Small Molecules
Molecules, 2015 Plasmin, a key serine protease, plays a major role in clot lysis and extracellular matrix remodeling. Heparin, a natural polydisperse sulfated glycosaminoglycan, is known to allosterically modulate plasmin activity.
Rami A. Al-Horani +3 more
doaj +1 more source
Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin. [PDF]
PLoS ONE, 2015 Removal of dead cells in the absence of concomitant immune stimulation is essential for tissue homeostasis. We recently identified an injury-induced protein misfolding event that orchestrates the plasmin-dependent proteolytic degradation of necrotic ...
Rachael J Borg +9 more
doaj +1 more source
Micromachines, 2021 We used the research quartz crystal microbalance (RQCM) to monitor regulatory effects of plasmin and trypsin in the presence of their inhibitor α2-antiplasmin.
Marek Tatarko +2 more
doaj +1 more source