Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b. [PDF]
PLoS ONE, 2012 Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Tina K Koch +7 more
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Plasmin Regulation through Allosteric, Sulfated, Small Molecules [PDF]
Molecules, 2015 Plasmin, a key serine protease, plays a major role in clot lysis and extracellular matrix remodeling. Heparin, a natural polydisperse sulfated glycosaminoglycan, is known to allosterically modulate plasmin activity.
Rami A. Al-Horani +3 more
doaj +5 more sources
Recombinant chymase inhibits fibrinolysis induced by endogenous plasmin in clotted human blood [PDF]
Frontiers in ImmunologyBackgroundOur group recently reported that chymase, a serine protease synthetized and released by mast cells, plays a pivotal role in thrombi stabilization in murine deep vein thrombosis (DVT) models, by interfering with the fibrinolytic properties of ...
Laurence Vincent +8 more
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Enhanced thrombin and plasmin generation profiles in alpha-2-antiplasmin–deficient patients: Data from the Rare Bleeding disorders in the Netherlands study [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: α2-Antiplasmin (A2AP) deficiency is a rare and often unidentified disorder characterized by increased fibrinolysis and subsequent bleeding. Global hemostasis assays may increase insight into the altered coagulation and fibrinolysis in these ...
Bauke Haisma +11 more
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Acute obstetric coagulopathy is associated with excess plasmin generation and proteolysis of fibrinogen and factor V [PDF]
Blood Advances: Hemostatic impairment may exacerbate postpartum hemorrhage (PPH). Previously, we described a distinct coagulopathy, associated with multiple causes of PPH including placental abruption and amniotic fluid embolus, termed acute obstetric coagulopathy ...
Peter W. Collins +8 more
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Exploitation of the fibrinolytic system by B-cell acute lymphoblastic leukemia and its therapeutic targeting [PDF]
Nature CommunicationsFibrinolysis influences the mobilization of hematopoietic stem cells from their bone marrow microenvironment (BMM). Here we show that activation of plasmin, a key fibrinolytic agent, by annexin A2 (ANXA2) distinctly impacts progression of BCR-ABL1+ B ...
Valentina R. Minciacchi +19 more
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Recent Advances in Milk Plasmin and Factors Affecting Its Activity [PDF]
Shipin Kexue, 2023 Plasmin is an important factor affecting the shelf-life quality of milk products, and its hydrolytic activity is regulated by many factors, such as activators, inhibitors, and activator inhibitors.
YANG Jinhui, QIAN Wentao, LI Hongliang, WANG Menghui, ZHAO Jingru, REN Xiaomin
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Pathophysiology of Plasmin System
The Tohoku Journal of Experimental Medicine, 1963 Masahiro Maki, Kazuma Nagasawa
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Chemosensors, 2022 Plasmin protease plays an important role in many processes in living systems, including milk. Monitoring plasmin activity is important for control of the nutritional quality of milk and other dairy products.
Sandro Spagnolo +3 more
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Gender affects skin wound healing in plasminogen deficient mice. [PDF]
PLoS ONE, 2013 The fibrinolytic activity of plasmin plays a fundamental role in resolution of blood clots and clearance of extravascular deposited fibrin in damaged tissues.
Birgitte Rønø +3 more
doaj +1 more source