Results 21 to 30 of about 65,619 (298)

CALIX[4]ARENES METHYLENE BISPHOSPHONIC ACIDS EFFECT ON PLASMIN ACTIVITY [PDF]

Biotechnologia Acta, 2018
The aim of the work was to study plasmin inhibiting properties of calix[4]arenes functionalized by phosphonic acid remnants. The following methods were used: turbidimetry, analysis of enzyme activity for chromogenic substrates, evaluation of caseinolytic
O. I. Yusova, O. V. Savchuk, T. Yatsenko, V. Popadiuk, L. G. Kapustianenko, T. V. Grinenko   +5 more
doaj   +1 more source

Contactless edema via plasmin [PDF]

Blood
Sidney Strickland, Erin H. Norris
openaire   +3 more sources

Decoding the role of angiopoietin-like protein 4/8 complex–mediated plasmin generation in the regulation of LPL activity

Journal of Lipid Research, 2023
After feeding, adipose tissue lipoprotein lipase (LPL) activity should be maximized, therefore the potent LPL-inhibitory activity of angiopoietin-like protein 4 (ANGPTL4) must be blocked by ANGPTL8 through formation of ANGPTL4/8 complexes.
Yan Q. Chen, Eugene Y. Zhen, Anna M. Russell, Mariam Ehsani, Robert W. Siegel, Yuewei Qian, Robert J. Konrad   +6 more
doaj   +1 more source

Synthesis of human plasminogen by the liver [PDF]

, 1980
Genetic types of plasminogen were determined from a donor and a recipient before and after hepatic homotransplantation. Examination of the plasminogen types demonstrated that the liver is the principal site of synthesis of human plasminogen.
Alper, CA, Levey, R, Marcus, D, Raum, D, Starzl, TE, Taylor, PD   +5 more
core   +1 more source

Prostasin-dependent activation of epithelial Na+ channels by low plasmin concentrations [PDF]

, 2009
Udgivelsesdato: 2009-Sep-30Several pathophysiological conditions, including nephrotic syndrome, are characterized by increased renal activity of the epithelial Na(+) channel (ENaC).
Jensen, Boye L, Palarasah, Yaseelan, Skjoedt, Karsten, Skøtt, Ole, Svenningsen, Per, Uhrenholt, Torben R   +5 more
core   +1 more source

Activation of Pro-uPA Is Critical for Initial Escape from the Primary Tumor and Hematogenous Dissemination of Human Carcinoma Cells

Neoplasia: An International Journal for Oncology Research, 2011
Urokinase-type plasminogen activator (uPA) and plasmin have long been implicated in cancer progression. However, the precise contributions of the uPA/plasmin system to specific steps involved in cancer cell dissemination have not been fully established ...
Erin M. Bekes, Elena I. Deryugina, Tatyana A. Kupriyanova, Ewa Zajac, Kenneth A. Botkjaer, Peter A. Andreasen, James P. Quigley   +6 more
doaj   +1 more source

Endoproteolysis of cellular prion protein by plasmin hinders propagation of prions

Frontiers in Molecular Neuroscience, 2022
Many questions surround the underlying mechanism for the differential metabolic processing observed for the prion protein (PrP) in healthy and prion-infected mammals.
Charles E. Mays, Trang H. T. Trinh, Trang H. T. Trinh, Glenn Telling, Glenn Telling, Glenn Telling, Hae-Eun Kang, Hae-Eun Kang, Hae-Eun Kang, Chongsuk Ryou, Chongsuk Ryou, Chongsuk Ryou, Chongsuk Ryou   +12 more
doaj   +1 more source

Markers of thrombogenesis and fibrinolysis and their relation to inflammation and endothelial activation in patients with idiopathic pulmonary arterial hypertension.

PLoS ONE, 2013
BackgroundChronic anticoagulation is a standard of care in idiopathic pulmonary arterial hypertension (IPAH). However, hemostatic abnormalities in this disease remain poorly understood.
Grzegorz Kopeć, Deddo Moertl, Sabine Steiner, Ewa Stępień, Tomasz Mikołajczyk, Jakub Podolec, Marcin Waligóra, Jakub Stępniewski, Lidia Tomkiewicz-Pająk, Tomasz Guzik, Piotr Podolec   +10 more
doaj   +1 more source

Enhanced thrombin and plasmin generation profiles in alpha-2-antiplasmin–deficient patients: Data from the Rare Bleeding disorders in the Netherlands study

Research and Practice in Thrombosis and Haemostasis
Background: α2-Antiplasmin (A2AP) deficiency is a rare and often unidentified disorder characterized by increased fibrinolysis and subsequent bleeding. Global hemostasis assays may increase insight into the altered coagulation and fibrinolysis in these ...
Bauke Haisma, Sanna R. Rijpma, Marjon H. Cnossen, Paul L. den Exter, Ilmar C. Kruis, Karina Meijer, Laurens Nieuwenhuizen, Nick van Es, Roger E.G. Schutgens, Nicole M.A. Blijlevens, Waander L. van Heerde, Saskia E.M. Schols   +11 more
doaj   +1 more source

X-ray crystal structure of plasmin with tranexamic acid–derived active site inhibitors

Blood Advances, 2017
: The zymogen protease plasminogen and its active form plasmin perform key roles in blood clot dissolution, tissue remodeling, cell migration, and bacterial pathogenesis.
Ruby H.P. Law, Guojie Wu, Eleanor W.W. Leung, Koushi Hidaka, Adam J. Quek, Tom T. Caradoc-Davies, Devadharshini Jeevarajah, Paul J. Conroy, Nigel M. Kirby, Raymond S. Norton, Yuko Tsuda, James C. Whisstock   +11 more
doaj   +1 more source