Unexpected timely fracture union in matrix metalloproteinase 9 deficient mice. [PDF]
PLoS ONE, 2018 Immediately following a fracture, a fibrin laden hematoma is formed to prevent bleeding and infection. Subsequently, the organized removal of fibrin, via the protease plasmin, is essential to permit fracture repair through angiogenesis and ossification ...
Masato Yuasa +10 more
doaj +1 more source
Plasmin plays an essential role in amplification of psoriasiform skin inflammation in mice. [PDF]
PLoS ONE, 2011 BACKGROUND:Although increased levels of plasminogen activators have been found in psoriatic lesions, the role of plasmin converted from plasminogen by plasminogen activators in pathogenesis of psoriasis has not been investigated.
Qun Li +8 more
doaj +1 more source
Plasmin drives burn-induced systemic inflammatory response syndrome
JCI Insight, 2021 Severe injuries, such as burns, provoke a systemic inflammatory response syndrome (SIRS) that imposes pathology on all organs. Simultaneously, severe injury also elicits activation of the fibrinolytic protease plasmin. While the principal adverse outcome
Breanne H. Y. Gibson +8 more
doaj +1 more source
Induction of brain microvascular endothelial cell urokinase expression by Cryptococcus neoformans facilitates blood-brain barrier invasion. [PDF]
PLoS ONE, 2012 The invasive ability of the blood-borne fungal pathogen Cryptococcus neoformans can be enhanced through interactions with host plasma components, such as plasminogen.
Jamal Stie, Deborah Fox
doaj +1 more source
Inhibition of plasmin by fibrinogen [PDF]
Biochemical Journal, 1990 The kinetics of inhibition of the amidolytic activity of plasmin on D-Val-L-Leu-L-Lys p-nitroanilide hydrochloride (S-2251) by fibrinogen and fibrin were determined. Reciprocal (1/v versus 1/[S]) plots of plasmin inhibition by 0.50 microM-fibrinogen showed a non-linear downward curve.
M Mayer, A A R Higazi
openaire +3 more sources
Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature. [PDF]
PLoS ONE, 2011 Clinical trials revealed beneficial effects of the broad-spectrum serine protease inhibitor aprotinin on the prevention of ischemia-reperfusion (I/R) injury. The underlying mechanisms remained largely unclear.
Christoph A Reichel +7 more
doaj +1 more source
Effects of stage of lactation and time of year on plasmin-derived proteolytic activity in bovine milk in New Zealand [PDF]
, 2002 The objective of this study was to determine the effects of stage of lactation (SOL) and time of year on plasmin-derived proteolytic activity in the milk of pasture-fed dairy cows in New Zealand. Four herds of 20 Friesian cows were used, one herd calving
Auldist, Martin J. +4 more
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On the Mechanism of Thrombolysis by Plasmin [PDF]
Circulation Research, 1962 I 131 -labeled purified human fibrin clots were introduced into the circulation of dogs at various time intervals after an infusion of human plasmin. One hour later, the clots were removed and incubated in saline at 37 C.
Julian L. Ambrus +2 more
openaire +3 more sources
Lens subluxation after plasmin and SF6 injections in rabbit eyes. [PDF]
PLoS ONE, 2014 To investigate the rate of lens subluxation following plasmin and/or SF6 injections in eyes, and whether a subsequent elevated level of vascular endothelial growth factor (VEGF) and vitreous tap would aggravate subluxation.Four groups of rabbits were ...
Wei-Chi Wu +8 more
doaj +1 more source
Micromachines, 2021 We used the research quartz crystal microbalance (RQCM) to monitor regulatory effects of plasmin and trypsin in the presence of their inhibitor α2-antiplasmin.
Marek Tatarko +2 more
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