Research and Practice in Thrombosis and HaemostasisBackground: α2-Antiplasmin (A2AP) deficiency is a rare and often unidentified disorder characterized by increased fibrinolysis and subsequent bleeding. Global hemostasis assays may increase insight into the altered coagulation and fibrinolysis in these ...
Bauke Haisma +11 more
doaj +1 more source
X-ray crystal structure of plasmin with tranexamic acid–derived active site inhibitors
Blood Advances, 2017 : The zymogen protease plasminogen and its active form plasmin perform key roles in blood clot dissolution, tissue remodeling, cell migration, and bacterial pathogenesis.
Ruby H.P. Law +11 more
doaj +1 more source
Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA [PDF]
, 2009 HGF (hepatocyte growth factor) is a pleiotropic cytokine homologous to the serine protease zymogen plasminogen that requires canonical proteolytic cleavage to gain functional activity.
Andrew M. Schumacher +47 more
core +3 more sources
Plasmin as a complement C5 convertase [PDF]
EBioMedicine, 2016 Both the complement and coagulation/fibrinolytic systems are essential components of the host defense system that evolved early in the evolution of vertebrates (Krem and Di Cera, 2002). While the coagulation and fibrinolytic systems are necessary for maintenance of the integrity of the vasculature, these systems also respond to infections, and together
John Morser, Lawrence L.K. Leung
openaire +4 more sources
Scientific Reports, 2017 Neuroserpin is a serine protease inhibitor that regulates the activity of plasmin and its activators in the neuronal tissues. This study provides novel evidence of regulatory effect of the neuroserpin on plasmin proteolytic activity in the retina in ...
Vivek Gupta +9 more
doaj +1 more source
Studies on identification of menstrual blood stain by fibrin-plate method. I. A study on the incoagulability of menstrual blood [PDF]
, 1962 As the results of present study on plasmin in menstrual blood by means of the Fibrin-Plate Method, a large amount of plasmin as much as dilution of 1: 100 or 1:1,000 of the menstrual blood serum, has been found in a natural form and it is deduced that ...
Shiraishi, Masumi
core +1 more source
Engineering Highly Cellularized Living Materials via Mechanical Agitation
Advanced Functional Materials, EarlyView.A mechanical agitation strategy is developed to engineer highly cellularized living materials, achieving cell densities of up to 1 billion cells per milliliter. By precisely tuning properties such as stiffness and toughness in blood clots, the approach is validated in both in vitro and in vivo studies.
Aram Bahmani +9 more
wiley +1 more source
Effects of Plasmin on von Willebrand Factor and Platelets: A Narrative Review
TH Open, 2018 Plasmin is the major fibrinolytic protease responsible for dissolving thrombi by cleavage of its primary substrate fibrin. In addition, emerging evidence points to other roles of plasmin: (1) as a back-up for ADAMTS13 in proteolysis of ultra-large von ...
Lisa N. van der Vorm +3 more
doaj +1 more source
Characterizing plasmin-induced lag phase and application of PDMS microfluidics to detection of fibrinolytic activity [PDF]
, 2018 Physical trauma is responsible for over six million deaths annually, and of these roughly 40 percent result from acute traumatic coagulopathy (ATC) occurring in the first few hours of incidence. Patients who have developed ATC have significantly improved
Ghani, Naveed
core
Safety and Efficacy of Hospital Utilization of Tranexamic Acid in Civilian Adult Trauma Resuscitation [PDF]
, 2020 Introduction: Patients with trauma-induced coagulopathies may benefit from the use of antifibrinolytic agents, such as tranexamic acid (TXA). This study evaluated the safety and efficacy of TXA in civilian adults hospitalized with traumatic hemorrhagic ...
Borger, Rodney +13 more
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