Results 31 to 40 of about 81,533 (325)
iScience, 2019 Summary: Dengue symptoms include alteration of blood coagulation and fibrinolysis, causing severe hemorrhage and death. Here, we demonstrate that higher concentration of plasmin, the human fibrinolytic factor, in blood meal enhances dengue virus (DENV ...
Karthik Ramesh +7 more
doaj +1 more source
Group B Streptococcus hijacks the host plasminogen system to promote brain endothelial cell invasion. [PDF]
PLoS ONE, 2013 Group B Streptococcus (GBS) is the leading cause of meningitis in neonates. We have previously shown that plasminogen, once recruited to the GBS cell surface and converted into plasmin by host-derived activators, leads to an enhancement of bacterial ...
Vanessa Magalhães +7 more
doaj +1 more source
On the Mechanism of Thrombolysis by Plasmin [PDF]
Circulation Research, 1962 I 131 -labeled purified human fibrin clots were introduced into the circulation of dogs at various time intervals after an infusion of human plasmin. One hour later, the clots were removed and incubated in saline at 37 C.
Julian L. Ambrus +2 more
openaire +3 more sources
Plasmin Regulation through Allosteric, Sulfated, Small Molecules
Molecules, 2015 Plasmin, a key serine protease, plays a major role in clot lysis and extracellular matrix remodeling. Heparin, a natural polydisperse sulfated glycosaminoglycan, is known to allosterically modulate plasmin activity.
Rami A. Al-Horani +3 more
doaj +1 more source
Micromachines, 2021 We used the research quartz crystal microbalance (RQCM) to monitor regulatory effects of plasmin and trypsin in the presence of their inhibitor α2-antiplasmin.
Marek Tatarko +2 more
doaj +1 more source
Endoproteolysis of cellular prion protein by plasmin hinders propagation of prions
Frontiers in Molecular Neuroscience, 2022 Many questions surround the underlying mechanism for the differential metabolic processing observed for the prion protein (PrP) in healthy and prion-infected mammals.
Charles E. Mays +12 more
doaj +1 more source
CALIX[4]ARENES METHYLENE BISPHOSPHONIC ACIDS EFFECT ON PLASMIN ACTIVITY [PDF]
Biotechnologia Acta, 2018 The aim of the work was to study plasmin inhibiting properties of calix[4]arenes functionalized by phosphonic acid remnants. The following methods were used: turbidimetry, analysis of enzyme activity for chromogenic substrates, evaluation of caseinolytic
O. I. Yusova +5 more
doaj +1 more source
Cell Discovery, 2017 Plasminogen activation is involved in many processes within the central nervous system, including synaptic plasticity, neuroinflammation and neurodegeneration. However, the mechanisms that regulate plasminogen activation in the brain still remain unknown.
A. Briens +6 more
semanticscholar +1 more source
Prostasin-dependent activation of epithelial Na+ channels by low plasmin concentrations [PDF]
, 2009 Udgivelsesdato: 2009-Sep-30Several pathophysiological conditions, including nephrotic syndrome, are characterized by increased renal activity of the epithelial Na(+) channel (ENaC).
Jensen, Boye L +5 more
core +1 more source
Neoplasia: An International Journal for Oncology Research, 2011 Urokinase-type plasminogen activator (uPA) and plasmin have long been implicated in cancer progression. However, the precise contributions of the uPA/plasmin system to specific steps involved in cancer cell dissemination have not been fully established ...
Erin M. Bekes +6 more
doaj +1 more source