Results 31 to 40 of about 63,325 (266)

Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin. [PDF]

PLoS ONE, 2015
Removal of dead cells in the absence of concomitant immune stimulation is essential for tissue homeostasis. We recently identified an injury-induced protein misfolding event that orchestrates the plasmin-dependent proteolytic degradation of necrotic ...
Rachael J Borg, Andre L Samson, Amanda E-L Au, Anja Scholzen, Martina Fuchsberger, Ying Y Kong, Roxann Freeman, Nicole A Mifsud, Magdalena Plebanski, Robert L Medcalf   +9 more
doaj   +1 more source

Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis [PDF]

, 2003
Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes.
Besch, R., Braungart, E., Degitz, K., Douwes, K., Flaig, M. J., Magdolen, V., Probst, C., Sander, C. A., Schuh, T., Wosikowski, K.   +9 more
core   +1 more source

Activation of Pro-uPA Is Critical for Initial Escape from the Primary Tumor and Hematogenous Dissemination of Human Carcinoma Cells

Neoplasia: An International Journal for Oncology Research, 2011
Urokinase-type plasminogen activator (uPA) and plasmin have long been implicated in cancer progression. However, the precise contributions of the uPA/plasmin system to specific steps involved in cancer cell dissemination have not been fully established ...
Erin M. Bekes, Elena I. Deryugina, Tatyana A. Kupriyanova, Ewa Zajac, Kenneth A. Botkjaer, Peter A. Andreasen, James P. Quigley   +6 more
doaj   +1 more source

CALIX[4]ARENES METHYLENE BISPHOSPHONIC ACIDS EFFECT ON PLASMIN ACTIVITY [PDF]

Biotechnologia Acta, 2018
The aim of the work was to study plasmin inhibiting properties of calix[4]arenes functionalized by phosphonic acid remnants. The following methods were used: turbidimetry, analysis of enzyme activity for chromogenic substrates, evaluation of caseinolytic
O. I. Yusova, O. V. Savchuk, T. Yatsenko, V. Popadiuk, L. G. Kapustianenko, T. V. Grinenko   +5 more
doaj   +1 more source

Group B Streptococcus hijacks the host plasminogen system to promote brain endothelial cell invasion. [PDF]

PLoS ONE, 2013
Group B Streptococcus (GBS) is the leading cause of meningitis in neonates. We have previously shown that plasminogen, once recruited to the GBS cell surface and converted into plasmin by host-derived activators, leads to an enhancement of bacterial ...
Vanessa Magalhães, Elva Bonifácio Andrade, Joana Alves, Adilia Ribeiro, Kwang Sik Kim, Margarida Lima, Patrick Trieu-Cuot, Paula Ferreira   +7 more
doaj   +1 more source

Identification of a Novel Mutation in the SERPINE1 Gene Causing Clinical Hyperfibrinolysis in English Springer Spaniel Dogs. [PDF]

J Vet Intern Med
ABSTRACT Background A 7‐month‐old female spayed English Springer Spaniel (ESS) was evaluated for spontaneous hemoperitoneum. Hyperfibrinolysis was identified on thromboelastography. Hypothesis/Objectives To identify a genetic mutation causing congenital hyperfibrinolysis in the proband and evaluate the prevalence of the mutation in the ESS breed ...
Kilpatrick K, Cullen JN, Almeer FF, Higgins L, Markowski T, Brooks M, Friedenberg SG, Racette M.   +7 more
europepmc   +2 more sources

Methodological factors influencing measurement and processing of plasma reelin in humans [PDF]

, 2003
BACKGROUND: Reelin, intensively studied as an extracellular protein that regulates brain development, is also expressed in a variety of tissues and a circulating pool of reelin exists in adult mammals.
Davis, John M, Keller, Flavio, Krueger, Jacqueline M, Lugli, Giovanni, Persico, Antonio M, Smalheiser, Neil R   +5 more
core   +3 more sources

Markers of thrombogenesis and fibrinolysis and their relation to inflammation and endothelial activation in patients with idiopathic pulmonary arterial hypertension.

PLoS ONE, 2013
BackgroundChronic anticoagulation is a standard of care in idiopathic pulmonary arterial hypertension (IPAH). However, hemostatic abnormalities in this disease remain poorly understood.
Grzegorz Kopeć, Deddo Moertl, Sabine Steiner, Ewa Stępień, Tomasz Mikołajczyk, Jakub Podolec, Marcin Waligóra, Jakub Stępniewski, Lidia Tomkiewicz-Pająk, Tomasz Guzik, Piotr Podolec   +10 more
doaj   +1 more source

Lytic and mechanical stability of clots composed of fibrin and blood vessel wall components. [PDF]

, 2013
Background Proteases expressed in atherosclerotic plaque lesions generate collagen fragments, release glycosaminoglycans (chondroitin sulfate [CS] and dermatan sulfate [DS]) and expose extracellular matrix (ECM) proteins (e.g.
Bóta, Attila, Kolev, K., Komorowicz, E., Longstaff, C., Machovich, R., Rottenberger, Z., Szabó, László, Varga, Zoltán   +7 more
core   +1 more source

Seprase: An overview of an important matrix serine protease [PDF]

, 2008
Seprase or Fibroblast Activation Protein (FAP) is an integral membrane serine peptidase, which has been shown to have gelatinase activity. Seprase has a dual function in tumour progression.
Abbott, Abbott, Abbott, Acharya, Adams, Adams, Aertgeerts, Aimes, Alcolado, Aoyama, Ariga, Artym, Bangert, Barrett, Bauvois, Bermpohl, Birney, Bissell, Brendan F. O'Connor, Brown, Busek, Chen, Chen, Chen, Chen, Cheng, Cheng, Christiansen, Collins, Corpet, De Wever, Del Rosso, Dolznig, Dvorak, Edosada, Edosada, Fassnacht, Fidler, Fink, Flentke, Fulop, Garcia-Horsman, Garin-Chesa, Gerner, Ghersi, Ghersi, Ghersi, Gilmore, Goldstein, Goldstein, Goodman, Gorrell, Guex, Hofheinz, Huang, Huber, Huber, Ibrahim, Iwasa, Jin, Kelly, Kelly, Kelly, Kelly, Kloft, Koyama, Lee, Lee, Lee, Lee, Lee, Levy, Levy, Levy, Loeffler, Mathew, Mersmann, Milner, Monsky, Mori, Mueller, Nicholas, Niedermeyer, Niedermeyer, Niedermeyer, Oertel, Okada, Okada, Ollis, Pamela O'Brien, Park, Pineiro-Sanchez, Ramirez-Montagut, Rennex, Rettig, Rettig, Rettig, Rettig, Rosenblum, Samel, Scanlan, Schechter, Scott, Scott, Sieweke, Skubitz, Stremenova, Sun, Tahtis, Tran, Wang, Wang, Welt, Welt, Wesley, Zhang   +115 more
core   +1 more source