Results 51 to 60 of about 63,325 (266)

Is urinary excretion of plasminogen associated with development of pre-eclampsia? An observational, explorative case–control study

BMJ Open, 2019
ObjectivesPre-eclampsia (PE) is characterised by renal glomerular endotheliosis and injury to the glomerular filtration barrier with proteinuria. Patients with PE display aberrant filtration of the plasma proenzyme plasminogen which is activated, in the ...
Lise H Nielsen, Camilla Kronborg, Erik Vittinghus, Gitte Kitlen, Boye L Jensen, Ulla B Knudsen, Per G Ovesen   +6 more
doaj   +1 more source

Endoproteolysis of cellular prion protein by plasmin hinders propagation of prions

Frontiers in Molecular Neuroscience, 2022
Many questions surround the underlying mechanism for the differential metabolic processing observed for the prion protein (PrP) in healthy and prion-infected mammals.
Charles E. Mays, Trang H. T. Trinh, Trang H. T. Trinh, Glenn Telling, Glenn Telling, Glenn Telling, Hae-Eun Kang, Hae-Eun Kang, Hae-Eun Kang, Chongsuk Ryou, Chongsuk Ryou, Chongsuk Ryou, Chongsuk Ryou   +12 more
doaj   +1 more source

Trypstatin as a Novel TMPRSS2 Inhibitor with Broad‐Spectrum Efficacy against Corona and Influenza Viruses

Advanced Science, EarlyView.
Trypstatin, a 61‐amino acid Kunitz‐type protease inhibitor derived from human Bikunin, potently inhibits TMPRSS2 and related proteases. It blocks spike‐ and hemagglutinin‐mediated entry of multiple respiratory viruses in vitro reduces SARS‐CoV‐2 replication in human airway cultures, and lowers viral load and symptoms in infected hamsters, demonstrating
Jan Lawrenz, Lukas Wettstein, Armando Rodríguez Alfonso, Rayhane Nchioua, Pascal von Maltitz, Dan Pascal Jean Albers, Fabian Zech, Julie Vandeput, Lieve Naesens, Giorgio Fois, Veronika Neubauer, Nico Preising, Emilia Schmierer, Yasser Almeida‐Hernandez, Moritz Petersen, Ludger Ständker, Sebastian Wiese, Peter Braubach, Manfred Frick, Eberhard Barth, Daniel Sauter, Frank Kirchhoff, Elsa Sanchez‐Garcia, Annelies Stevaert, Jan Münch   +24 more
wiley   +1 more source

Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin

Computational and Structural Biotechnology Journal, 2022
Cardio- and cerebrovascular diseases are leading causes of death and disability, resulting in one of the highest socio-economic burdens of any disease type.
Dmitri Nikitin, Jan Mican, Martin Toul, David Bednar, Michaela Peskova, Patricia Kittova, Sandra Thalerova, Jan Vitecek, Jiri Damborsky, Robert Mikulik, Sarel J. Fleishman, Zbynek Prokop, Martin Marek   +12 more
doaj  

Exercise, cognition and Alzheimer’s disease: More is not necessarily better [PDF]

, 2005
Regional hypoperfusion, associated with a reduction in cerebral metabolism, is a hallmark of Alzheimer’s disease (AD) and contributes to cognitive decline. Cerebral perfusion and hence cognition can be enhanced by exercise.
Adlard, Alessi, Anton, Attwell, Baumbach, Bierman, Carmeliet, Chen, Chen, Churchill, Cohen, Colcombe, Cooke, Corder, Cott, Critchley, Cumming, Daley, De la Torre, Dick Swaab, Diesfeldt, Dubelaar, Eldridge, Endres, Erik Scherder, Farkas, Fedele, Fernández-Vizarra, Folstein, Fratiglioni, Friedman, Graham, Guigoz, Hamel, Harkany, Hayward, Hellström, Herrmann, Herrmann, Hoffman, Huang, Hönigfeld, Iadecola, Ide, Ide, Ide, Jagust, Johnson, Jørgensen, Katz, Keller, Kivipelto, Koike, Koistinaho, Kubes, Kurosawa, Launer, Laura Eggermont, Lawton, Lazowski, Lehtovirta, Liesi, Lijnen, Lindenmuth, MacRae, Martel, Matsuda, Matsuda, Maxwell, Melchor, Meltzer, Meyer, Miklossy, Monji, Morgan, Moro, Mulder, Muldowney, Nagahama, Nagai, Nakajima, Namazi, Naso, Palleschi, Palmer, Parihar, Paul Luiten, Petersen, Plutchik, Pober, Pott, Powell, Prager, Prunell, Raven, Reiman, Reitan, Rolland, Roth, Salehi, Scherder, Schini-Kerth, Selley, Skoog, Smith, Sobel, Spinler, Srikiatkhachorn, Suzuki, Swaab, Swaab, Swaab, Swain, Tappen, Tappen, Teri, Tinetti, Tong, Tong, Tsolaki, Tucker, Tucker, Ueda, Ushijima, Van de Winckel, Van Dyck, Van Gelder, Wang, Warkentin, Wechsler, Wechsler, Weller, Wenk, Whelton, White, Wilson, Wolf, Zarit   +137 more
core   +1 more source

In vitro ultrastructure and biodegradation of activated plasma albumin gel derived from human samples: A prospective observational study

Clinical Advances in Periodontics, EarlyView.
Abstract Background In soft tissue regeneration, the clinical efficacy of fibrin membranes has been a pressing concern. The key to this efficacy lies in the stability of membrane and its controlled absorption. Human serum albumin, with its influence on the formation and stability of fibrin networks, could hold the key to developing a more stable ...
Behzad Houshmand, Mohammadreza Talebi Ardakani, Farshad Armandei, Anahita Moscowchi, Ahmad Nazari, Jafar Ai, Mehdi Ekhlasmand Kermani, Hamoun Sabri   +7 more
wiley   +1 more source

Deferasirox Derivatives as Inhibitors of Kallikrein‐Related Peptidases Associated to Neurodegenerative Diseases

ChemMedChem, EarlyView.
Dysregulated proteolysis mediated by kallikrein‐related peptidases (KLKs) and iron overload are involved in the progression of neurodegenerative diseases. Deferasirox, an clinically‐approved iron chelator, and its newly synthesized derivatives have been identified as inhibitors of major central nervous system KLKs with low cytotoxicity and effective ...
Rilès Boumali, Elodie David, Nancy Chaaya, Morane Lucas, Sabrina Aït Amiri, Valérie Lefort, Anthony Nina‐Diogo, Michèle Salmain, Isabelle Petropoulos, Vincent Corcé, Chahrazade El Amri, Candice Botuha   +11 more
wiley   +1 more source

Establishing the Inhibition of the Serine Protease Plasmin as a Skin Anti-Aging Pathway

Cosmetics
Plasmin is a serine protease induced by UV-irradiation in skin that contributes to inflammation. We showed that plasmin is upregulated in photo-exposed facial skin and that this correlates with increased transepidermal water loss (TEWL). Plasmin activity
Remo Campiche, Dominik Imfeld, Chennakesava Cuddapah, Leithe Budel, Mathias Gempeler   +4 more
doaj   +1 more source

Mutant and chimeric recobinant plasminogen activatorsproduction in eukaryotic cellsand preliminary characterization [PDF]

, 1987
Mutant urokinase-type plasminogen activator (u-PA) genes and hybrid genes between tissue-type plasminogen activator (t-PA) and u-PA have been designed to direct the synthesis of new plasminogen activators and to investigate the structure-function ...
Andre, B., Bollen, A., Collen, D., Cravador, A., Deforesta, F., Dewilde, M., Gheysen, D., Herzog, A., Hoylaerts, M., Jacobs, P., Pierard, L., Topisirovic, L.   +11 more
core   +1 more source

Causal correlations between inflammatory proteins and heart failure: A two‐sample Mendelian randomization analysis

ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.
Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu, Gui‐Qin Liu, Ya‐Ping Peng, Li‐Ling Zhang, Xian‐Jin Wang, Liang‐Chuan Chen, Yuan‐Xi Zheng, Xue‐Jun Xiang, Rui Qiao, Xian‐He Lin   +9 more
wiley   +1 more source