Results 161 to 170 of about 234,694 (355)

Interaction of Streptokinase and Human Plasminogen

open access: hybrid, 1966
Brian C. W. Hummel   +2 more
openalex   +1 more source

Blockade of cannabinoid CB1 receptors potentiates the anti‐fibrotic effects mediated by SGLT2 inhibition in a mouse model of diabetic nephropathy

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and purpose Diabetic nephropathy (DN) is a common complication of diabetes. Current treatments include renin‐angiotensin‐aldosterone system (RAAS) blockers and sodium‐glucose co‐transporter 2 (SGLT2) inhibitors. The cannabinoid CB1 receptor is a potential therapeutic target.
Océane Pointeau   +20 more
wiley   +1 more source

Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?

open access: yesBritish Journal of Pharmacology, EarlyView.
Psychedelic drugs that activate 5‐HT2A receptors have been long used for cultural, medicinal and recreational purposes. Interest in psychedelics for treating psychiatric disorders has resurged recently and is well documented; less well recognised are their anti‐inflammatory properties. Growing evidence now demonstrates that psychedelics modulate immune
Omar Qureshi   +10 more
wiley   +1 more source

Role of leukocytes in hemostasis during orthotopic liver transplantation [PDF]

open access: yes, 1993
Bechstein, W. O.   +8 more
core   +1 more source

Elucidating the Role and Mechanism of Alpha‐Enolase in Senescent Amelioration via Metabolic Reprogramming

open access: yesCell Proliferation, EarlyView.
KB2764 interacted with alpha‐enolase (ENO1) and pyruvate kinase M (PKM), ultimately leading to PKM phosphorylation of ENO1. KB2764 consequently increased mitochondrial ATP production and decreased glycolysis dependence. Furthermore, the action of KB2764 extends its application to extend the lifespan of Caenorhabditis elegans.
Yun Haeng Lee   +13 more
wiley   +1 more source

Deciphering Age‐Dependent ECM Remodelling in Liver: Proteomic Profiling and Its Implications for Aging and Therapeutic Targets

open access: yesCell Proliferation, EarlyView.
This study reveals age‐dependent remodelling of the liver extracellular matrix (ECM), identifying Lumican as a key regulator of hepatocyte proliferation and stemness in foetal development. Dynamic ECM shifts influence liver function, offering insights into therapeutic strategies for aging‐related hepatic decline.
Juan Liu   +8 more
wiley   +1 more source

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