Results 1 to 10 of about 3,602,430 (295)

Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients

open access: yesScientific Reports, 2021
Patients with coronavirus disease-19 (COVID-19) are at high risk for thrombotic arterial and venous occlusions. However, bleeding complications have also been observed in some patients.
Y. Zuo   +9 more
semanticscholar   +2 more sources

Plasminogen activator inhibitors. [PDF]

open access: yesBlood, 1987
Chemicals/CAS: fibrin, 9001-31-4; plasminogen activator inhibitor, 105844-41-5; plasminogen activator, 9039-53-6; Carrier Proteins; Glycoproteins; Plasminogen Activators, EC 3.4.21.-; Plasminogen Inactivators; Protease Inhibitors; protease ...
E. Sprengers, C. Kluft
semanticscholar   +5 more sources

Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial

open access: yesNature Medicine, 2021
Early increase of soluble urokinase plasminogen activator receptor (suPAR) serum levels is indicative of increased risk of progression of coronavirus disease 2019 (COVID-19) to respiratory failure.
E. Kyriazopoulou   +63 more
semanticscholar   +3 more sources

A Narrative Review on Plasminogen Activator Inhibitor-1 and Its (Patho)Physiological Role: To Target or Not to Target?

open access: yesInternational Journal of Molecular Sciences, 2021
Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of plasminogen activators (PAs) and is therefore an important inhibitor of the plasminogen/plasmin system.
M. Sillen, P. Declerck
semanticscholar   +1 more source

The Plasminogen–Activator Plasmin System in Physiological and Pathophysiological Angiogenesis

open access: yesInternational Journal of Molecular Sciences, 2021
Angiogenesis is a process associated with the migration and proliferation of endothelial cells (EC) to form new blood vessels. It is involved in various physiological and pathophysiological conditions and is controlled by a wide range of proangiogenic ...
A. Ismail, B. Shaker, K. Bajou
semanticscholar   +1 more source

Tissue Plasminogen Activator [PDF]

open access: yesNew England Journal of Medicine, 1989
Coronary thrombolysis has been proved to be beneficial in the treatment of myocardial infarction. Much attention has been focused on tissue-type plasminogen activator (t-PA) as a fibrinolytic agent. This article will discuss the unique properties of t-PA and the role of the critical care nurse in providing the safe delivery of t-PA.
openaire   +4 more sources

Phosphorylation of human plasminogen activators and plasminogen [PDF]

open access: yesFEBS Letters, 1995
Plasminogen (PG), urokinase‐type plasminogen activator (u‐PA) and tissue‐type PA (t‐PA) are the main molecules involved in fibrinolysis and in many other physiological and pathological processes. In the present study we report that human t‐PA, purified from human melanoma cells, and PG, purified from human plasma, both contain P‐Tyr residues, as ...
BARLATI, Sergio   +4 more
openaire   +3 more sources

Plasminogen activators and plasminogen activator inhibitors in endometriosis

open access: yesFrontiers in Bioscience, 2005
Endometriosis is one of the most frequent benign gynecological diseases that affect women. Little is known about the pathogenesis and etiology of endometriosis, despite the numerous studies performed in this field. Although endometriosis is a benign disease, the endometrial tissue, after attachment to the peritoneum, has the ability to grow and invade ...
Gilabert-Estelles, J   +6 more
openaire   +4 more sources

Multifaceted Role of the Urokinase-Type Plasminogen Activator (uPA) and Its Receptor (uPAR): Diagnostic, Prognostic, and Therapeutic Applications

open access: yesFrontiers in Oncology, 2018
The plasminogen activator (PA) system is an extracellular proteolytic enzyme system associated with various physiological and pathophysiological processes.
Niaz Mahmood, C. Mihalcioiu, S. Rabbani
semanticscholar   +1 more source

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