Radiology and Oncology, 2016 The association of HER2 status with urokinase plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1) levels raises the question whether uPA/PAI-1 level carries additional clinically relevant prognostic information independently from ...
Dovnik Nina Fokter, Takac Iztok
doaj +1 more source
Differential effects of tissue plasminogen activator and streptokinase on infarct size and on rate of enzyme release: influence of early infarct related artery patency: The GUSTO Enzyme Substudy [PDF]
, 2017 Background The recent international GUSTO trial of 41 021 patients with acute myocardial infarction demonstrated improved 90-mm infarct related artery patency as well as reduced mortality in patients treated with an accelerated regimen of tissue ...
Baardman, T. +6 more
core
The epidemiology and pathogenesis of uterine fibroids
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Uterine fibroids, or leiomyomas, are the most common benign tumors of the female reproductive tract, ultimately affecting a majority of women worldwide, primarily during their reproductive years. While their origin appears genetic, manifesting in monoclonal tumors, diverse features and mechanisms contribute to their growth and further ...
Malcolm G. Munro +2 more
wiley +1 more source
Studies on Plasminogen Activators. II. A Method for the Separation of Purified Urokinase from Small Samples of Urine. [PDF]
, 1966 Ulla Hamberg +7 more
openalex +1 more source
Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling. [PDF]
, 2015 In glioblastoma (GBM), the EGF receptor (EGFR) and Src family kinases (SFKs) contribute to an aggressive phenotype. EGFR may be targeted therapeutically; however, resistance to EGFR-targeting drugs such as Erlotinib and Gefitinib develops quickly.
Cavenee, WK +5 more
core
The Journal of Clinical Pharmacology, EarlyView.Abstract Corticosteroids are effective anti‐cancer agents for treating hematologic malignancies in children. However, avascular necrosis (AVN) is a common and debilitating adverse effect, leading to bone death and impacting long‐term quality of life. This study aimed to uncover the genetic factors contributing to corticosteroid‐induced AVN in a well ...
Miguel Cordova‐Delgado +9 more
wiley +1 more source
Plasminogen activator activity in cultures from human tissues. An immunological and histochemical study [PDF]
, 1969 Maria B. Bernik, Hau C. Kwaan
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A personal 360° view of applications of ‘biomimetic’ molecular recognition
Journal of Chemical Technology &Biotechnology, EarlyView.Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley +1 more source
Feasibility of Treating Eosinophilic Chronic Rhinosinusitis Using Short‐Chain Fatty Acids
The Laryngoscope, EarlyView.Epithelial cell‐derived cytokines including thymic stromal lymphopoietin (TSLP) are important in the pathogenesis of chronic rhinosinusitis with nasal polyps. We demonstrate the inhibitory effect of TSLP production in airway epithelial cells and eosinophil survival by short‐chain fatty acids (SCFAs) as a potential new strategy to reduce nasal polyps ...
Rikako Gozawa +12 more
wiley +1 more source
The activation of plasminogen by staphylokinase: comparison with streptokinase [PDF]
, 1960 Flora M. Davidson
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