Results 261 to 270 of about 3,530,803 (397)

STAT6 Activation Exacerbates Ferroptosis in Airway Epithelium by Inhibiting PRKN‐Mediated Mitophagy in Pulmonary Fibrosis

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study uncovers STAT6‐driven pulmonary fibrosis (PF) via suppression of PRKN‐mediated airway epithelial mitophagy, triggering mitochondrial dysfunction and ferroptosis. Rifabutin is identified as a potent STAT6 inhibitor that effectively reverses fibrotic progression. These findings reveal the STAT6‐PRKN axis as a pathogenic regulator and provide a
Youjing Yang, Guangbin Huang, Tao Zhang, Yi Ling, Junyu Jiang, Dingyuan Du, Yu Ma, Shasha Tao   +7 more
wiley   +1 more source

Sustained Expression of Plasminogen Activator Inhibitor-1 in Patients Recovered from COVID-19 Disease. [PDF]

Med Princ Pract
Mayer O, Bílková S, Nezbedová T, Karnosová P, Windrichová J, Hirmerová J, Pazdiora P, Filipovský J.   +7 more
europepmc   +1 more source

Thrombolysis in myocardial infarction (TIMI) trial—Phase I: Hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase

, 1988
Anupama Rao, Craig M. Pratt, Andrew Berke, Allan S. Jaffe, Ira S. Ockene, Theodore Schreiber, William R. Bell, Genell L. Knatterud, Thomas Robertson, Michael L. Terrin   +9 more
openalex   +1 more source

PLAUR+ Neutrophils Drive Anti‐PD‐1 Therapy Resistance in Patients with Hepatocellular Carcinoma by Shaping an Immunosuppressive Microenvironment

Advanced Science, Volume 12, Issue 38, October 13, 2025.
The present study reveals that PLAUR+ neutrophils are enriched in immunotherapy non‐responders and correlate with poor prognosis. PLAUR+ neutrophils dictate immunotherapy resistance in hepatocellular carcinoma by forming an immunosuppressive tumor microenvironment characterized by CD8+ T cell exclusion and macrophage‐dependent immune suppression.
Shaoqing Liu, Yanzhao Zhou, Gaoxiang Li, Bingwen Zhu, Fang Wu, Jinxue Zhou, Xiaobing Chen, Bo Qin, Yanxia Gao, Fazhan Wang, Yong Jiang, Wenxin Xu   +11 more
wiley   +1 more source

Cardiac Rupture and Death Following Administration of Recombinant Tissue-Type Plasminogen Activator (rt-PA). [PDF]

Cureus
Saito T, Ishii T, Aoki T, Zenko M, Yanagisawa K, Otsuki Y, Sugiura R, Kondo Y.   +7 more
europepmc   +1 more source

Plasminogen Activation Initiated by Single-chain Urokinase-type Plasminogen Activator

, 1989
Vincent Ellis, Michael Scully, V. V. Kakkar   +2 more
openalex   +1 more source

Tissue Plasminogen Activator [PDF]

New England Journal of Medicine, 1989
openaire   +2 more sources

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke

Nature Network Boston, 2008
E. Su, L. Fredriksson, M. Geyer, E. Folestad, J. Cale, Johanna Andrae, Yamei Gao, K. Pietras, Kris M. Mann, M. Yepes, D. Strickland, C. Betsholtz, U. Eriksson, D. Lawrence   +13 more
semanticscholar   +1 more source

Cancer Cell‐Derived Large Extracellular Vesicles Promote Venous Thromboembolism by Activating NETosis Through Delivering CYBA

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Venous thromboembolism (VTE) is a major threat to cancer patients. Cancer‐derived large extracellular vesicles deliver CYBA (p22phox) to neutrophils, triggering reactive oxygen species (ROS) and citrullinated histone H3 (citH3) formation. This drives neutrophil extracellular traps formation (NETosis), elevating VTE risk.
Xiangji Li, Yingjiao Ju, Chenjie Xu, Shixiang Ma, Lan Sun, Qingdong Guo, Mingyuan Liu, Yibin Xie, Li Min   +8 more
wiley   +1 more source

Enhancing Thrombolysis Safety in Post-Acute Ischemic Stroke with Tissue Plasminogen Activator-Associated Microparticles. [PDF]

ACS Nano
Spanò R, Portioli C, Geroski T, Felici A, Palange AL, Gawne PJ, Mamberti S, Avancini G, Palomba R, Bonnard T, Moore TL, Del Sette M, Filipovic N, Vivien D, Decuzzi P.   +14 more
europepmc   +1 more source