Results 301 to 310 of about 3,479,441 (357)
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Plasminogen activation and cancer
Thrombosis and Haemostasis, 2005SummaryBreakdown of the extracellular matrix is crucial for cancer invasion and metastasis. It is accomplished by the concerted action of several proteases, including the serine protease plasmin and a number of matrix metalloproteases. The activity of each of these proteases is regulated by an array of activators, inhibitors and cellular receptors ...
Danø, Keld +6 more
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Plasminogen Activators and Angiogenesis
1996The formation of capillaries from preexisting blood vessels (angiogenesis) occurs in a variety of normal and pathological conditions, including organ development, would healing and tumor growth. Angiogenesis requires a strict temporal modulation of opposing cell functions: cell proliferation and migration, and extracellular matrix (ECM) degradation in ...
P, Mignatti, D B, Rifkin
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Plasminogen activator and cancer
European Journal of Cancer and Clinical Oncology, 1984Plasminogen activator is a protease which catalyses the conversion of the inactive plasminogen to the active plasmin. Most transformed cell lines and solid tumors produce elevated levels of plasminogen activator compared with nontransformed counterparts. This increased synthesis of plasminogen activator may play a role in tumorigenesis, cancer invasion
M J, Duffy, P, O'Grady
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Plasminogen activator inhibitors
Trends in Cardiovascular Medicine, 1991Plasminogen activator inhibitors (PAIs) regulate plasminogen activation in normal and pathologic processes. Plasminogen activator inhibitor 1 (PAI-1) is the major physiologic inhibitor of both tissue-type and urokinase-type plasminogen activators. It is a highly regulated single-chain glycoprotein, whose overexpression in vivo impairs the fibrinolytic ...
J, Schneiderman, D J, Loskutoff
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Zymographic Evaluation of Plasminogen Activators and Plasminogen Activator Inhibitors
2004Publisher Summary The plasminogen activator/plasminogen activator inhibitor (PA/PAI) system is of considerable fundamental importance in elucidating the biochemical mechanisms of many physiological and patho-physiological processes. Although many techniques are available to assess the PA/PAI system, including ELISA and molecular assays, fibrin ...
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Inhibitory effect of angiostatins on activity of the plasminogen/plasminogen activator system
Biochemistry (Moscow), 2009Angiostatins, kringle-containing fragments of plasminogen, are potent inhibitors of angiogenesis. Effects of three angiostatin forms, K1-3, K1-4, and K1-4.5 (0-2 microM), on the rate of native Glu-plasminogen activation by its physiological activators in the absence or presence of soluble fibrin were investigated in vitro.
R B, Aisina +6 more
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The potentiating effect of platelet on plasminogen activation by tissue plasminogen activator
Thrombosis Research, 1985A new role for platelets in fibrinolysis is proposed. Platelets (euglobulin from platelet rich plasma and from human platelet extract) may potentiate plasminogen activation by tissue plasminogen activator (tPA). The potentiating activity was detected by both chromogenic substrate and fibrin plate analysis. The fibrinolysis-potentiating substance in the
K, Deguchi +6 more
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Differences in the activation rates of plasminogen by tissue plasminogen activator and urokinase
Thrombosis Research, 1987The activation of a native form of plasminogen (Glu-plg) by tissue plasminogen activator(t-PA) was enhanced when the plasma was clotted by the addition of thrombin or thrombin plus Ca++. Cross-linking of fibrin in the clotted plasma did not inhibit the fibrin-associated enhancement of the activation of plasminogen by t-PA.
A, Takada, K, Shizume, M, Cho, Y, Takada
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Activating effect of the plasminogen activators on plasminogens of different mammalia species
Thrombosis Research, 1995Abstract Plasmin (E.C. 3.4.21.7.) is a major serine proteolytic enzyme responsible for fibrinolytic function in mammalia blood plasma. It is formed by activation of proenzyme plasminogen with the known activators such as urokinase (UK, E.C. 3.4.21.31.), tissue-type plasminogen activator (t-PA, E.C. 3.4.21.67.) or streptokinase (SK) (1, 2).
S A, Yakovlev +3 more
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Plasminogen/plasminogen activator and growth factor activation.
Ciba Foundation symposium, 1998The plasminogen/plasminogen activator system is widely used in extracellular proteolysis. In this review the involvement of this system in tumour invasion, cell migration, growth factor presentation and inhibition of angiogenesis are discussed.
Rifkin, DB +6 more
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