Results 331 to 340 of about 3,530,803 (397)
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Plasminogen activation by tissue plasminogen activator in the presence of platelets
Thrombosis Research, 1988Platelets were found to provide a surface for activation of plasminogen by the tissue-type plasminogen activator (t-PA) at an optimum concentration and to potentiate the generation of plasmin by the amidolytic method, fibrin lysis time and fibrin plate method.
Katsumi Deguchi, Shigeru Shirakawa
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Activation of Bovine Plasminogen by the Plasminogen Activator in Animal Tissue
Thrombosis and Haemostasis, 1960Summary1. The activation of bovine plasminogen by means of the plasminogen activator from pig heart tissue has been studied on heated fibrin and on casein.2. Small, but varying, amounts of activator can be extracted from crude activator powder during the experiment and interfere therefore with estimations on normal, plasminogen containing fibrin.3. The
Takeshi Abe, Tage Astrup
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Tissue Activator of Plasminogen
Nature, 1964SINCE Astrup and Permin1 reported that animal tissue cells contain an activator of plasminogen, various authors have confirmed their results, and comparisons of the activator content of different human2 and animal tissues3,4 have been published. Most authors have used whole tissue or aqueous tissue extracts and have estimated activity by the fibrin ...
Charles H. Lack, S. Yousuf Ali
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Platelets and Plasminogen Activation
Thrombosis and Haemostasis, 1995Platelets serve as a site for assembly of the proteins of the plasminogen activator system. Once bound to the platelet surface, tissue-type plasminogen activator manifests enhanced catalytic activity. Plasmin, once formed, also binds to the platelets surface and, at low concentrations, renders the platelet dysfunctional by cleaving glycoprotein IIIa ...
Joseph Loscalzo +3 more
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Plasminogen activator / plasminogen activator inhibitors in ovarian physiology
Frontiers in Bioscience, 2004The target extracellular matrix (ECM) degradation generated by plasminogen activator (PA) and regulated by plasminogen activator inhibitor (PAI) is an event that affects a wide variety of physiological and pathological processes in the ovary. Studies carried out over the past 25 years in a number of laboratories have elucidated some of the biochemical ...
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Plasminogen activators: A comparison
Vascular Pharmacology, 2006Thrombolytic drugs play a crucial role in the management of patients with acute myocardial infarction, pulmonary embolism, deep vein thrombosis, arterial thrombosis, acute thrombosis of retinal vessel, extensive coronary emboli, and peripheral vascular thromboembolism.
M.R. Chaudhari +3 more
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Plasminogen activation and cancer
Thrombosis and Haemostasis, 2005SummaryBreakdown of the extracellular matrix is crucial for cancer invasion and metastasis. It is accomplished by the concerted action of several proteases, including the serine protease plasmin and a number of matrix metalloproteases. The activity of each of these proteases is regulated by an array of activators, inhibitors and cellular receptors ...
Danø, Keld +6 more
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Studies on the kinetics of plasminogen activation by tissue plasminogen activator
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1982The steady-state rate of plasminogen activation by tissue plasminogen activator has been determined at various plasminogen concentrations. A plasmin substrate method similar to that presented by Christensen and Müllertz (Biochim. Biophys. Acta 480 (1977) 257-281) was used.
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Plasminogen Activators and Angiogenesis
1996The formation of capillaries from preexisting blood vessels (angiogenesis) occurs in a variety of normal and pathological conditions, including organ development, would healing and tumor growth. Angiogenesis requires a strict temporal modulation of opposing cell functions: cell proliferation and migration, and extracellular matrix (ECM) degradation in ...
D. B. Rifkin, P. Mignatti
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Mechanisms of plasminogen activation
Journal of Internal Medicine, 1994The fibrinolytic system consists of an inactive proenzyme, plasminogen, that is converted by plasminogen activators to the active enzyme, plasmin, that degrades fibrin. Two immunologically distinct plasminogen activators have been identified: tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA).
S. Thorsen +6 more
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