Results 151 to 160 of about 180,408 (257)
An investigation of the nature of plasminogen activator inhibitor type-I (PAI-I) to improve upon known small molecule inhibitors [PDF]
, 2019 Plasminogen activator inhibitor type-I (PAI-I ) is a serpin superfamily member protein that acts as the major inhibitor of tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA).
Powers, Justin A.
core +1 more source
Application of Proteomics in Maternal and Neonatal Health: Advancements and Future Directions
PROTEOMICS – Clinical Applications, EarlyView.ABSTRACT Maternal and neonatal health (women during pregnancy, childbirth, and the postnatal period) presents a spectrum of healthcare challenges, including preterm birth, preeclampsia, intrauterine growth restriction, polycystic ovarian syndrome, and gestational diabetes mellitus.
Razan Elkahlout +6 more
wiley +1 more source
Clinical periodontal diagnosis
Periodontology 2000, EarlyView., 2023 Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi +5 more
wiley +1 more source
Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta. [PDF]
, 1991 Michael Sawdey, David J. Loskutoff
openalex +1 more source
PROTEOMICS – Clinical Applications, EarlyView.ABSTRACT Background Capillary blood collection has a number of advantages over venous collection, especially in the context of increasing decentralized clinical trials and field‐based testing. No studies are available comparing venous versus capillary blood collection for proteomics measurement.
Mary Ni Lochlainn +4 more
wiley +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Hereditary angioedema (HAE) is a rare genetic disease that manifests as recurrent, unpredictable, and potentially life‐threatening attacks of angioedema. Garadacimab is a first‐in‐class, fully human, monoclonal antibody targeting activated factor XII (FXIIa) that is under clinical development for the long‐term prophylaxis of HAE attacks.
Ramon Garcia +11 more
wiley +1 more source
Platelets inhibit fibrinolysis in vitro by both plasminogen activator inhibitor-1-dependent and -independent mechanisms [PDF]
, 1994 WP Fay +4 more
openalex +1 more source
Small, EarlyView.PIM1 is screened out and verified its correlation with sepsis‐induced coagulopathy by bioinformatic analysis and clinical research. Then a multifunctional co‐delivery system (MPDA@PEI@GM) is proposed for the co‐deliver of the PIM1 inhibitors SMI‐4a and small interfering RNA (siPIM1) to reduce PIM1 expression, which effectively inhibits the expression ...
Aiming Zhou +11 more
wiley +1 more source