Results 181 to 190 of about 180,408 (257)

Engineered pulmonary artery tissues for measuring contractility, drug testing and disease modelling

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Vasoreactivity of pulmonary arteries regulates blood flow through the lungs. Excessive constriction of these vessels contributes to pulmonary arterial hypertension (PAH), a progressive and incurable condition, resulting in right heart failure.
Adam L. Fellows, Kate Quigley, Venus Leung, Alexander J. Ainscough, Martin R. Wilkins, Harry Barnett, David Miller, Manuel Mayr, Beata Wojciak‐Stothard   +8 more
wiley   +1 more source

Binding of tissue-type plasminogen activator with human endothelial cell monolayers. Characterization of the high affinity interaction with plasminogen activator inhibitor-1.

, 1990
M. P. Russell, Thomas Quertermous, Paul Declerck, Désiré Collen, E Haber, C J Homcy   +5 more
openalex   +1 more source

An antisense oligonucleotide targeting the heat‐shock protein HSPB5 as an innovative therapeutic approach in pulmonary fibrosis

British Journal of Pharmacology, EarlyView.
Background and Purpose Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by fibroblast activation and abnormal accumulation of extracellular matrix in the lungs. We previously demonstrated the importance of the heat shock protein αB‐crystallin (HSPB5) in TGF‐β1 profibrotic signalling, which suggests that HSPB5 could be a new ...
Pierre‐Marie Boutanquoi, Lenny Pommerolle, Lucile Dondaine, Julie Tanguy, Pierre‐Simon Bellaye, Léo Biziorek, Marine Gautier‐Isola, Bernard Mari, Denis Masnikov, Palma Rocchi, Pascal Finetti, Patricia Korczak, Brune Vialet, Philippe Barthelemy, Carmen Garrido, Philippe Bonniaud, Olivier Burgy, Françoise Goirand   +17 more
wiley   +1 more source

Cell Biology of Cancer Peritoneal Metastasis: Multiclonal Seeding and Peritoneal Tumor Microenvironment

Cancer Science, EarlyView.
We summarize recent findings on the cell biological aspects of peritoneal metastasis and potential therapeutic target molecules. We focus on the molecular mechanisms underlying cluster/spheroid formation in multiclonal peritoneal metastasis and cancer–stroma interactions within the peritoneal tumor microenvironment. ABSTRACT Peritoneal metastasis, also
Hideki Yamaguchi, Makoto Miyazaki
wiley   +1 more source

Permeable Lung Vasculature Creates Chemoresistant Endothelial Niche by Producing SERPINE1 at Breast Cancer Metastatic Sites

Cancer Science, EarlyView.
Vascular permeability is increased by lung metastasis, which correlates with YAP activation in ECs. Activated ECs provide SERPINE1 to neighboring cancer cells to promote chemoresistance and stemness. ABSTRACT Chemotherapy resistance remains a major obstacle for eradicating metastatic cancer cells in distant organs. We identified that endothelial cells (
Tsunaki Hongu, Sarenqiqige, Shandan, Hirokazu Kusunoki, Akihiko Ishimura, Takeshi Suzuki, Thordur Oskarsson, Noriko Gotoh   +7 more
wiley   +1 more source

Alteration of serpin specificity by a protein cofactor. Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties.

, 1990
H. J. Ehrlich, Raymond Klein Gebbink, Jaap Keijer, M Linders, Klaus T. Preissner, Hans Pannekoek   +5 more
openalex   +1 more source

Endocytosis and lysosomal delivery of tissue plasminogen activator- inhibitor 1 complexes in Hep G2 cells [PDF]

, 1992
David M. Underhill, DA Owensby, PA Morton, Anna L. Schwartz   +3 more
openalex   +1 more source

Obesity‐related glomerulopathy: How it happens and future perspectives

Diabetic Medicine, EarlyView.
Abstract Obesity‐related glomerulopathy (ORG) is an emerging complication of excess adiposity. Its incidence rises alongside the obesity pandemic. Up to 40% of individuals can be affected by ORG, irrespective of the status of glomerular filtration rate and albuminuria.
Jian‐Wen Samuel Lee‐Boey, Jia‐Kai Tan, Zhan‐Foong Lim, Francesco Zaccardi, Kamlesh Khunti, Majid Ezzati, Edward W. Gregg, Lee‐Ling Lim   +7 more
wiley   +1 more source

Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin.

, 1991
Dietmar Seiffert, David J. Loskutoff
openalex   +1 more source

The Transcription Factor EGR-1 Suppresses Transformation of Human Fibrosarcoma HT1080 Cells by Coordinated Induction of Transforming Growth Factor-β1, Fibronectin, and Plasminogen Activator Inhibitor-1 [PDF]

, 1999
Chaoting Liu, Jin Yao, Ian de Belle, Ruo‐Pan Huang, Eileen D. Adamson, Dan Mercola   +5 more
openalex   +1 more source