Plasminogen activator inhibitor-1 (PAI-1) expression in endometriosis.
PLoS ONE, 2019 PurposeDeep infiltrating endometriosis (DIE) is defined as an endometriotic lesion penetrating to a depth of >5 mm and is associated with pelvic pain, but the underlying mechanisms are unclear.
Fahad T Alotaibi +8 more
doaj +1 more source
Effects of moderate weight loss on anginal symptoms and indices of coagulation and fibrinolysis in overweight patients with angina pectoris [PDF]
, 2002 Objective: To evaluate the effects of moderate weight loss, in overweight patients with angina, on plasma coagulation, fibrinolytic indicies and pain frequency.
Hankey, C.R. +4 more
core +1 more source
Egyptian Journal of Medical Human Genetics, 2018 Background: Many genetic factors, including polymorphisms in the genes regulating blood coagulation and fibrinolysis have been proposed as risk factors for coronary artery disease (CAD).
Hanan Al-Wakeel +3 more
doaj +1 more source
The uPA System Differentially Alters Fibroblast Fate and Profibrotic Ability in Skin Fibrosis
Frontiers in Immunology, 2022 Skin fibrosis is a common pathological feature of various diseases, and few treatment strategies are available because of the molecular pathogenesis is poorly understood.
Ming-Li Zou +15 more
doaj +1 more source
Plasminogen Activator Inhibitor-1 [PDF]
Circulation, 2013 Hypertension is the most common reversible risk factor for stroke, myocardial infarction, and heart failure, affecting >60 million individuals in the United State alone and 1 billion globally.1 According to the World Health Organization, hypertension is now the leading cause of preventable death worldwide.2 Importantly, the prevalence and complications
Daniel I, Simon, Norman M, Simon
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Plasminogen activator inhibitor-1: a review Plasminogen-Aktivator-Inhibitor-1: eine Übersicht [PDF]
LaboratoriumsMedizin, 2005 Abstract Plasminogen activator inhibitor-1 (PAI-1) is the most potent inhibitor of both tissue type (t-PA) and urokinase type plasminogen activator (u-PA) and thus regulates fibrinolysis as well as proteolysis, cell migration, and tumor cell invasiveness.
Markus Pihusch +2 more
openaire +1 more source
Platelets retain high levels of active plasminogen activator inhibitor 1. [PDF]
PLoS ONE, 2011 The vascular fibrinolytic system is crucial for spontaneous lysis of blood clots. Plasminogen activator inhibitor 1 (PAI-1), the principal inhibitor of the key fibrinolytic enzyme tissue-type plasminogen activator (tPA), is present in platelets at high ...
Helén Brogren +4 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2021 Plasminogen activator inhibitor 1 (PAI-1) is a member of the serine protease inhibitor (serpin) superfamily. PAI-1 is the principal inhibitor of the plasminogen activators, tissue plasminogen activator (tPA), and urokinase-type plasminogen activator (uPA)
Gael B. Morrow +3 more
doaj +1 more source
The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans [PDF]
, 2017 The neurovascular unit provides a dynamic interface between the circulation and central nervous system. Disruption of neurovascular integrity occurs in numerous brain pathologies including neurotrauma and ischaemic stroke. Tissue plasminogen activator is
Beckham, Simone +15 more
core
LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response [PDF]
, 2016 LDL receptor-related protein-1 (LRP1) is an endocytic and cell-signaling receptor. In mice in which LRP1 is deleted in myeloid cells, the response to lipopolysaccharide (LPS) was greatly exacerbated.
Azmoon, Pardis +5 more
core +1 more source