Platelets retain high levels of active plasminogen activator inhibitor 1. [PDF]
PLoS ONE, 2011 The vascular fibrinolytic system is crucial for spontaneous lysis of blood clots. Plasminogen activator inhibitor 1 (PAI-1), the principal inhibitor of the key fibrinolytic enzyme tissue-type plasminogen activator (tPA), is present in platelets at high ...
Helén Brogren +4 more
doaj +1 more source
Estimating the Roles of Protonation and Electronic Polarization in Absolute Binding Affinity Simulations [PDF]
arXiv, 2021 Accurate prediction of binding free energies is critical to streamlining the drug development and protein design process. With the advent of GPU acceleration, absolute alchemical methods, which simulate the removal of ligand electrostatics and van der Waals interactions with the protein, have become routinely accessible and provide a physically ...
arxiv
Growth and fibrinolytic parameters of human umbilical vein endothelial cells seeded onto cardiovascular grafts [PDF]
, 1995 It was the aim of this study to investigate possible effects of biomaterials used to produce vascular grafts on the fibrinolytic system of endothelial cells.
Binder, Bernd R. +2 more
core +1 more source
The role of pulses in improving human health: A review
Legume Science, Volume 4, Issue 4, December 2022., 2022 Abstract Public health concerns are discussed so frequently that it is beginning to cause desensitization. And yet, rates of chronic disease remain alarmingly high worldwide—or are even increasing. Primary prevention is essential to reverse these trends.
Chelsea Didinger, Henry J. Thompson
wiley +1 more source
Plasminogen activator inhibitor-1 (PAI-1) expression in endometriosis.
PLoS ONE, 2019 PurposeDeep infiltrating endometriosis (DIE) is defined as an endometriotic lesion penetrating to a depth of >5 mm and is associated with pelvic pain, but the underlying mechanisms are unclear.
Fahad T Alotaibi +8 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2021 Plasminogen activator inhibitor 1 (PAI-1) is a member of the serine protease inhibitor (serpin) superfamily. PAI-1 is the principal inhibitor of the plasminogen activators, tissue plasminogen activator (tPA), and urokinase-type plasminogen activator (uPA)
Gael B. Morrow +3 more
doaj +1 more source
Activation Functions: Dive into an optimal activation function [PDF]
arXiv, 2022 Activation functions have come up as one of the essential components of neural networks. The choice of adequate activation function can impact the accuracy of these methods. In this study, we experiment for finding an optimal activation function by defining it as a weighted sum of existing activation functions and then further optimizing these weights ...
arxiv
Expression pattern of the urokinase-plasminogen activator system in rat DS-sarcoma: Role of oxygenation status and tumour size [PDF]
The urokinase plasminogen activator system plays a central role in malignant tumour progression. Both tumour hypoxia and enhancement of urokinase plasminogen activator, urokinase plasminogen activator-receptor and plasminogen activator inhibitor type 1 ...
A Maity +34 more
core +2 more sources
The impact of the gene variants fv leiden, fii g20210a, mthfr c677t and pai-1 4g/5g on pregnancy loss in women from central Serbia [PDF]
, 2020 © 2020, University of Kragujevac, Faculty of Science. All rights reserved. Thrombophilia is a condition of enhanced functionality of the haemostatic system with an increased tendency for thrombosis, and it can be a congenital, acquired, or complex defect.
Jovic, Nikola +4 more
core +1 more source
The effects of endocrine‐disrupting chemicals on ovarian‐ and ovulation‐related fertility outcomes
Molecular Reproduction and Development, Volume 89, Issue 12, Page 608-631, December 2022., 2022 Abstract Exposure to endocrine‐disrupting chemicals (EDCs) is unavoidable, which represents a public health concern given the ability of EDCs to target the ovary. However, there is a large gap in the knowledge about the impact of EDCs on ovarian function, including the process of ovulation.
Katie L. Land +3 more
wiley +1 more source