Results 181 to 190 of about 3,326,153 (390)

Elucidating the Role and Mechanism of Alpha‐Enolase in Senescent Amelioration via Metabolic Reprogramming

open access: yesCell Proliferation, EarlyView.
KB2764 interacted with alpha‐enolase (ENO1) and pyruvate kinase M (PKM), ultimately leading to PKM phosphorylation of ENO1. KB2764 consequently increased mitochondrial ATP production and decreased glycolysis dependence. Furthermore, the action of KB2764 extends its application to extend the lifespan of Caenorhabditis elegans.
Yun Haeng Lee   +13 more
wiley   +1 more source

Transcranial Histotripsy Clot and Tissue Ablation for Intracerebral Hemorrhage Evacuation and Other Brain Applications

open access: yes, 2023
STROKE: Vascular and Interventional Neurology, EarlyView.
Jonathan Sukovich   +2 more
wiley   +1 more source

Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia

open access: yesNeurobiology of Disease, 2007
Tetracyclines inhibit matrix metalloproteinases (MMPs) and reduce infarction volume following cerebral ischemia. In this thesis an involvement of urokinase could be proven.
Dorothe Burggraf   +3 more
doaj  

Recurrent hypoglycemia exposure increases the risk of platelet activation and thrombosis in insulin‐treated diabetic rats

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Diabetes is a widespread disease associated with long‐term complications. Treatment of diabetes alleviates these complications but cause an increased risk of recurrent hypoglycemia (RH). Hypoglycemia exposure increases the risk of cardiovascular events by an unknown mechanism.
Ashish K. Rehni   +8 more
wiley   +1 more source

Proteomic associations with fluctuation and long‐term changes in BMI: A 40‐year follow‐up study

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Introduction While some studies have explored associations between weight change and blood proteins, most have been intervention‐based, offering limited insight into proteomic associations with long‐term weight gain. It remains unclear whether plasma proteins are related to BMI fluctuation over time.
Alvaro Obeso   +6 more
wiley   +1 more source

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