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Clinical Chemistry and Laboratory Medicine, 2008 Myeloperoxidase (MPO) neutrophils have been considered an important pathophysiological factor in oxidative stress. Mainly through generation of hypochlorous acid in the phagosome, unchecked activity may lead to inactivation of important proteins through modification of tyrosine and other residues.
Alejandro Gugliucci
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Peroxynitrite Inactivates Tissue Plasminogen Activator
Anesthesia & Analgesia, 2004Tissue plasminogen activator (tPA) has a prominent role in physiological fibrinolysis in vivo. Thrombosis has been associated with clinical scenarios (e.g., atherosclerotic disease) known to involve local decreases in tPA activity with concomitant formation of reactive nitrogen species such as peroxynitrite (OONO(-)), a molecule formed from nitric ...
Vance G, Nielsen +3 more
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Inactivation of plasminogen activator inhibitor by oxidants
Biochemistry, 1986The rapidly acting plasminogen activator inhibitor (PAI) purified from cultured bovine aortic endothelial cells (BAEs) was inactivated during iodination with chloramine T and other oxidizing iodination systems. Inactivation was observed in the absence of iodine, suggesting that the loss of activity resulted from the oxidizing conditions employed. In an
D A, Lawrence, D J, Loskutoff
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Susceptibility of plasminogen activators to suicide inactivation
Thrombosis Research, 1988Halomethylated derivatives of dihydrocoumarins are efficient enzyme-activated inhibitors ("suicide" substrates) of plasminogen activators. Kinetic analysis indicate that the one-chain and two-chain forms of the human plasminogen activator are inhibited by 3,4-dihydro-3-benzyl-6-chloromethylcoumarin through a mechanism-based inactivation characterized ...
A, Mor +3 more
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Selective Inactivation of the Plasminogen Contaminant in Thrombin
Nature, 1960THE contamination of preparations of thrombin and fibrinogen with plasminogen, the precursor of the fibrinolytic enzyme, has always presented great difficulties in the measurement of fibrinolytic activity.
G, MARKUS, C M, AMBRUS
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Inactivation of Human Serum Plasminogen Antiactivator by Synthetic Fibrinolysis Inducers
Thrombosis and Haemostasis, 1969SummaryHuman serum plasminogen antiactivator was separated from serum antiplasmin by isoelectric precipitation and ammonium sulfate fractionation followed by Sephadex chromatography. With the use of human vascular activator it was demonstrated that the serum antiactivator is functionally distinct from serum antiplasmin.
N, Aoki, K N, von Kaulla
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Fibrin Targeting of Echogenic Liposomes with Inactivated Tissue Plasminogen Activator
Journal of Liposome Research, 2008Fibrin-specific molecular targeting strategies are desirable for site-specific imaging and treatment of late stage atheroma, but fibrin-specific antibodies are difficult to produce and present immunogenicity problems. Tissue plasminogen activator (tPA) is an endogenous protein that has been shown to bind fibrin with high affinity and may circumvent ...
Melvin E, Klegerman +2 more
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A cyclopeptidic suicide substrate preferentially inactivates urokinase-type plasminogen activator
Biochemical and Biophysical Research Communications, 1991c[Arg-aB-(CH2+SCH3 phi)-Gly4] was designed and studied as a mechanism-based inactivator (suicide substrate) for plasminogen activators (u-PA and t-PA) and plasmin. This compound inhibited u-PA and fulfills criteria expected for the involvement of an enzyme-activated inhibitor: first-order and irreversible process, saturation kinetics, protection by ...
M, Reboud-Ravaux +7 more
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