Results 131 to 140 of about 648 (173)

Heat Inactivation of Native Plasminogen Activators in Bovine Milk

Journal of Food Science, 1993
ABSTRACT Inactivation of plasminogen activators appeared to follow first‐order kinetics in the temperature range tested. The Arrhenius plot was linear (correlation coefficient 0.990). The Arrhenius equation for heat inactivation was deduced, from which the rate of inactivation at any temperature in the range 60–140°C could be ...
DONGJIN D. LU, S. SUZANNE NIELSEN
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Biological Effects of Combined Inactivation of Plasminogen Activator and Plasminogen Activator Inhibitor-1 Gene Function in Mice

Thrombosis and Haemostasis, 1995
SummaryMice with combined homozygous deficiency of tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA) (T‾U‾), of t-PA and plasminogen activator inhibitor-1 (PAI-1) (T‾P‾), of u-PA and PAI-1 (U‾P‾) or of t-PA, u-PA, and PAI-1 (T‾U‾P‾) were generated by inbreeding of mice with the respective deficiencies.
H R, Lijnen, L, Moons, V, Beelen, P, Carmelie, D, Collen   +4 more
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Human Plasminogen Is Highly Susceptible to Peroxynitrite Inactivation

Clinical Chemistry and Laboratory Medicine, 2003
It has been shown that diabetic patients have up to three-fold increases in plasma nitrated tyrosine. We hypothesize that nitration of plasminogen could impair its catalytic properties and be a factor in diabetic thrombogenicity. To test this hypothesis, in this study we addressed the effects of the peroxynitrite donor 3-morpholinosydnonimine (SIN-1 ...
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Inactivation of Plasminogen Activator Inhibitor-1 by RNA Aptamer Molecules

Blood, 2012
Abstract Abstract 1107 Introduction: The serine protease inhibitor (serpin) plasminogen activator inhibitor-1 (PAI-1), binds and inhibits the following plasminogen activators: tissue-type plasminogen activator (tPA), and urokinase-type plasminogen activator (uPA). This decreases plasmin
Yolanda Fortenberry, Jared Damare
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Inactivation of single-chain urokinase-type plasminogen activator by thrombin in human subjects

Journal of Laboratory and Clinical Medicine, 1999
Thrombin cleaves single-chain urokinase-type plasminogen activator (scu-PA) into a virtually inactive two-chain form (tcu-PA/T), a process that may protect a blood clot from early fibrinolysis. It is not known under what circumstances tcu-PA/T can be generated in vivo.
Braat, E.A.M., Levi, M., Bos, R., Haverkate, F., Lassen, M.R., Maat, M.P.M. de, Rijken, D.C.   +6 more
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Effect of Peptides on the Inactivation of Tissue Plasminogen Activator by Plasminogen Activator Inhibitor-1 and on the Binding of Tissue Plasminogen Activator to Endothelial Cells

Thrombosis and Haemostasis, 1990
SummaryThe effectiveness of tissue plasminogen activator (tPA) in thrombolytic therapy is dependent upon the rate at which therapeutically administered tPA reaches the clot site and the proportion of that tPA which is enzymatically active. Interactions between tPA and its main plasma inhibitor (PAI-1) and between tPA and the endothelial cells lining ...
A J, Wittwer, M A, Sanzo
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Inactivation of the plasminogen activator from HeLa cells by peptides of arginine chloromethyl ketone

Biochimica et Biophysica Acta (BBA) - Enzymology, 1979
The binding specificities of human urinary urokinase (EC 3.4.99.26) and HeLa cell plasminogen activator were studied using peptidyl chloromethyl ketone inhibitors. A 125I-labeled fibrin assay has been developed to yield kinetic information. Reagents of the sequence X-Gly-ArgCH2Cl were the most effective.
P, Coleman, C, Kettner, E, Shaw
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Acid treatment of plasma for the inactivation of plasminogen activator inhibitor-1 (PAI-1)

Thrombosis Research, 1988
The present study was initiated to assess the effectiveness of various acid treatments of blood or plasma in the inactivation of PAI-1. It was shown that a frequently used treatment of blood or plasma with 1 M acetate buffer, pH 3.9, only partially inactivated PAI-1.
M P, de Maat, C, Kluft, K, de Boer, E A, Knot, A F, Jie   +4 more
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Visualization of Thrombi in Pulmonary Arteries With Radiolabeled, Enzymatically Inactivated Tissue-Type Plasminogen Activator

Circulation, 1995
Background Despite the high frequency of pulmonary thromboembolism and its significant morbidity and mortality, diagnosis remains suboptimal. We have been developing a method for prompt detection with the use of radiolabeled, inactivated tissue-type plasminogen activator (TPA) and performed the present study to determine ...
V H, De Bruyn, S R, Bergmann, B A, Keyt, B E, Sobel   +3 more
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Urokinase Activation of Plasminogen and Spontaneous Inactivation of the Plasmin Formed

Thrombosis and Haemostasis, 1968
SummaryThe kinetics of the activation of plasminogen into plasmin with urokinase and the inactivation rate of the plasmin formed are studied.As a first order reaction is obtained with low plasminogen concentrations and a zero-order reaction is obtained with high concentrations, the activation seems to follow the Michaelis-Menten’s law.
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