Results 141 to 150 of about 648 (173)

Activation And “Inactivation” Of A Plasminogen Proactivator (Preurokinase) In Human Tissue Culture Media

Thrombosis and Haemostasis, 1981
Besides active plasminogen activators, the synthesis of a proactivator (preurokinase) has been reported in cell and tissue cultures. It is suggested that slow activation of the proactivator in the culture medium occurs by an unknown proteolytic mechanism.
G Wijngaards, M B Bernik
openaire   +1 more source

Regulation of Gelatinase Activity in Mice with Targeted Inactivation of Components of the Plasminogen/Plasmin System

Thrombosis and Haemostasis, 1998
SummaryTo investigate a potential physiological role of the plasminogen/ plasmin system in activation of the matrix metalloproteinase (MMP) system, the distribution of latent and active MMP-2 (gelatinase A) or MMP-9 (gelatinase B) was monitored in aorta extracts and in serum-free conditioned cell culture medium obtained from wild-type (WT) mice and ...
H R, Lijnen, J, Silence, G, Lemmens, L, Frederix, D, Collen   +4 more
openaire   +2 more sources

One chain variants of tissue plasminogen activator have increased susceptibility to inactivation by plasmin

Fibrinolysis, 1991
Abstract Tissue plasminogen activator (t-PA) is synthesised as a one chain molecule which can be converted to a two chain form by hydrolysis of the peptide bond after the arginine at position 275 by plasmin. Variants with non-basic residues at position 275 are resistant to this hydrolysis. However, incubation of these variants with plasmin can result
D.L. Higgins, S.L. Young, A. Wong
openaire   +1 more source

Poly-d-lysine dependent inactivation of tissue plasminogen activator by a class pai-2 inhibitor (minactivin)

Thrombosis Research, 1987
Two-chain tissue plasminogen activator (t-PA) was found to be inactive in a coupled colorimetric assay for plasminogen activators, but a high level of activity was obtained in the presence of poly-D-lysine. This stimulated activity was strongly inhibited by minactivin, a urokinase inhibitor, but unstimulated enzyme could be shown to be unaffected by ...
K C, Leung, J A, Byatt, R W, Stephens
openaire   +2 more sources

Plasminogen-dependent and -independent Proteolytic Activity of Murine Endothelioma Cells with Targeted Inactivation of Fibrinolytic Genes

Thrombosis and Haemostasis, 1997
SummaryPlasminogen-dependent and -independent proteolytic activity of murine endothelioma (End) cells that were derived from mice with targeted inactivation of the tissue-type plasminogen activator (t-PA -/-), urokinase-type plasminogen activator (u-PA-/-) or plasminogen activator inhibitor-1 (PAI-1 -/- genes was studied with the use of fibrin and ...
H R, Lijnen, E F, Wagner, D, Collen
openaire   +2 more sources

Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial

Nature Medicine, 2021
Evdoxia Kyriazopoulou, Haralampos Milionis, Konstantinos Tsiakos   +2 more
exaly  

Increased Euglobulin Fibrinolytic Potential in Women on Oral Contraceptives Low in Oestrogen – Levels of Extrinsic and Intrinsic Plasminogen Activators, Prekallikrein, Factor XII, and C1-Inactivator

, 1985
Jørgen Jespersen, Cornelis Kluft
openalex   +1 more source

Crystal Structure of a novel small molecule inactivator bound to plasminogen activator inhibitor-1

, 2012
Jeanne A. Stuckey, Daniel A. Lawrence, S.-H. Li   +2 more
openalex   +1 more source

Inactivation of tissue plasminogen activator in plasma

Atherosclerosis, 1988
openaire   +1 more source

Biological effects of inactivation of the genes for tissue-type plasminogen activator, urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in mice

Fibrinolysis, 1993
P. Carmeliet, L. Schoonjans, L. Kieckens, J.M. Stassen, R. Bronson, D. Collen, R. Mulligant   +6 more
openaire   +1 more source