Results 71 to 80 of about 317,079 (354)

A clustered regularly interspaced palindromic repeat‐Cas12a‐based assay for rapid dengue virus monitoring in mosquito and clinical samples facilitating global collaborative surveillance and risk assessment to block dengue spreading

Interdisciplinary Medicine, EarlyView.
The RAA‐Cas12a assay outperforms real‐time PCR in sensitivity (92.3%) while matching its specificity (100%) for dengue virus detection in clinical samples. It effectively identifies DENV in mosquitoes, with field data correlating to local outbreaks. This rapid, simple, and precise method serves as an early warning tool for dengue management.
Xiang Guo, Minling Hu, Ying Lu, Xiaohua Liu, Haiyang Chen, Xiaoqing Zhang, Liu Ge, Ziyao Li, Yuji Wang, Qing He, Shu Zeng, Wenwen Ren, Lingzhai Zhao, Zhiqiang Peng, Wushen Chen, Chunmei Wang, Qingming Kong, Shaohong Lu, Fuchun Zhang, Lei Luo, Hua Li, Xiao‐Guang Chen, Xiaohong Zhou   +22 more
wiley   +1 more source

A small mitochondrial protein present in myzozoans is essential for malaria transmission [PDF]

Open Biology, 2016
Myzozoans (which include dinoflagellates, chromerids and apicomplexans) display notable divergence from their ciliate sister group, including a reduced mitochondrial genome and divergent metabolic processes.
Dennis Klug, Gunnar R. Mair, Friedrich Frischknecht, Ross G. Douglas   +3 more
doaj   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it

Immunological Reviews, 2019
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites have the unique capacity to infect and replicate within host erythrocytes.
Anja T. R. Jensen, Yvonne Adams, L. Hviid   +2 more
semanticscholar   +1 more source

Artificial intelligence strategies for predicting kinase inhibitor resistance: A comprehensive review of methods, challenges, and future perspectives

Journal of Intelligent Medicine, EarlyView.
Abstract Kinase inhibitors are essential in targeted cancer therapy, yet resistance often emerges through secondary mutations, activation of compensatory signaling pathways, or drug‐efflux mechanisms. Artificial intelligence (AI) provides a workflow‐based strategy rather than a list of unrelated tools for predicting and addressing kinase‐inhibitor ...
Faris Hassan, Mohanad Ali Deifallah, Alaa Zaghloul, Rania Elgohary   +3 more
wiley   +1 more source

CONVENTIONAL AND MOLECULAR DETECTION OF PLASMODIUM IN HUMANS

Pakistan Journal of Agriculture, Agricultural Engineering & Veterinary Sciences, 2017
Conventional and molecular detection of plasmodium, causative agent of malaria was carried out, during 2014-15 aiming at comparing the sensitivity of both the protocols. For conventional diagnosis, thin blood smear from 50 malaria suspected victims from
S. N. Panhwar, A. Arijo, M. B. Bhutto, Z. I. Rajput, R. S. Buriro   +4 more
doaj  

Potential herd protection against Plasmodium falciparum infections conferred by mass antimalarial drug administrations

eLife, 2019
The global malaria burden has decreased over the last decade and many nations are attempting elimination. Asymptomatic malaria infections are not normally diagnosed or treated, posing a major hurdle for elimination efforts.
Daniel M Parker, Sai Thein Than Tun, Lisa J White, Ladda Kajeechiwa, May Myo Thwin, Jordi Landier, Victor Chaumeau, Vincent Corbel, Arjen M Dondorp, Lorenz von Seidlein, Nicholas J White, Richard J Maude, François Nosten   +12 more
doaj   +1 more source

GAMETOCYTEMIA IN PLASMODIUM VIVAX AND PLASMODIUM FALCIPARUM INFECTIONS [PDF]

Journal of Parasitology, 2006
Two expert research microscopists, each blinded to the other's reports, diagnosed single-species malaria infections in 2,141 adults presenting at outpatient malaria clinics in Tak Province, Thailand, and Iquitos, Peru, in May-August 1998, May-July 1999, and May-June 2001.
F Ellis, Mckenzie, Chansuda, Wongsrichanalai, Alan J, Magill, J Russ, Forney, Barnyen, Permpanich, Carmen, Lucas, Laura M, Erhart, Wendy P, O'Meara, David L, Smith, Jeeraphat, Sirichaisinthop, Robert A, Gasser   +10 more
openaire   +2 more sources

Pupil Plane Multiplexing for Vectorial Fourier Ptychography

Laser &Photonics Reviews, EarlyView.
This study proposes a cost‐effective, modality‐adaptive multichannel microscopy framework using pupil‐plane multiplexing. A custom pupil aperture at the Fourier plane encodes channel‐specific transfer functions with spectral or polarization filters, and model‐based reconstruction with channel‐dependent priors decodes them.
Hyesuk Chae, Kyungwon Lee, Yong Guk Kang, Hansol Yoon, Kyung Chul Lee, Seung Ah Lee   +5 more
wiley   +1 more source

The Sporozoite's Journey Through the Mosquito: A Critical Examination of Host and Parasite Factors Required for Salivary Gland Invasion

Frontiers in Ecology and Evolution, 2019
Although much progress has been made in the fight against malaria, the number of people that contract this disease due to the bite of an Anopheline mosquito remains unacceptably high.
Bianca B. Kojin, Zach N. Adelman
doaj   +1 more source