Results 91 to 100 of about 32,923 (246)

In Vitro and In Vivo Antimalarial Activity of LZ1, a Peptide Derived from Snake Cathelicidin

Toxins, 2019
Antimalarial drug resistance is an enormous global threat. Recently, antimicrobial peptides (AMPs) are emerging as a new source of antimalarials. In this study, an AMP LZ1 derived from snake cathelicidin was identified with antimalarial activity.
Yaqun Fang, Xiaoqin He, Pengcheng Zhang, Chuanbin Shen, James Mwangi, Cheng Xu, Guoxiang Mo, Ren Lai, Zhiye Zhang   +8 more
doaj   +1 more source

Evolution of virulence: triggering host inflammation allows invading pathogens to exclude competitors. [PDF]

, 2008
Virulence is generally considered to benefit parasites by enhancing resource-transfer from host to pathogen. Here, we offer an alternative framework where virulent immune-provoking behaviours and enhanced immune resistance are joint tactics of invading ...
Alizon S., Anderson R.M., Andre J.B., Dawkins R., Gordon D.M., Kerr B., Odling-Smee F.J., Otto S.P., Plunkett G., Poulin R.   +9 more
core   +2 more sources

Expression and purification of E140 protein antigen fragments of Plasmodium vivax and Plasmodium berghei for serological assays

FEBS Open Bio, Volume 15, Issue 5, Page 690-698, May 2025.
We provide a step‐by‐step guide for producing E140 antigen fragments from Plasmodium berghei (Pb1) and Plasmodium vivax (Pv1). Pb1/Pv1 are expressed in E. coli, solubilized by freeze–thawing, refolded by slow dilution, purified by affinity chromatography (IMAC), then concentrated and subjected to quality control.
Rodolfo Ferreira Marques, Edit Ábrahám, Hiromi Muramatsu, Daniel Youssef Bargieri, Norbert Pardi, Zoltán Lipinszki   +5 more
wiley   +1 more source

The Plasmodium eukaryotic initiation factor-2α kinase IK2 controls the latency of sporozoites in the mosquito salivary glands [PDF]

, 2010
Sporozoites, the invasive form of malaria parasites transmitted by mosquitoes, are quiescent while in the insect salivary glands. Sporozoites only differentiate inside of the hepatocytes of the mammalian host. We show that sporozoite latency is an active
Anat Caspi, Balagopal, Beatriz M.A. Fontoura, Boyce, Boyd, Bruña-Romero, Chakraborty, Chakraborty, Christian Doerig, Clare Fennell, Coppi, Dar, David S. Roos, Elizabeth A. Winzeler, Fennell, Ferreira da Silva, Florens, Gantt, Janse, Kaiser, Kappe, Kebaier, Kedersha, Khater, Lasonder, Le Roch, Lisa Ranford-Cartwright, Mair, Meis, Min Zhang, Mota, Mueller, Narasimhan, Pascale Gueirard, Paton, Porter, Proud, Ramanavelan Sakthivel, Renu Tuteja, Robert Ménard, Ruth S. Nussenzweig, Sherman, Stephan Meister, Sullivan, Sullivan, Thompson, Tsuji, Tuteja, Van Der Kelen, Vanderberg, Vervenne, Victor Nussenzweig, Ward, William J. Sullivan, Yamauchi, Yoshida, Yoshida, Zhou   +57 more
core   +2 more sources

Neuroimmune Pain and Its Manipulation by Pathogens

Evolutionary Applications, Volume 18, Issue 4, April 2025.
ABSTRACT Recent studies highlight extensive crosstalk that exists between sensory neurons responsible for pain and the immune system. Cutaneous pain neurons detect harmful microbes, recruit immune cells, and produce anticipatory immunity in nearby tissues. These complementary systems generally protect hosts from infections.
Kevin W. Lozo, Athena Aktipis, Joe Alcock   +2 more
wiley   +1 more source

Neuregulin-1 attenuates experimental cerebral malaria (ECM) pathogenesis by regulating ErbB4/AKT/STAT3 signaling. [PDF]

, 2018
BACKGROUND:Human cerebral malaria (HCM) is a severe form of malaria characterized by sequestration of infected erythrocytes (IRBCs) in brain microvessels, increased levels of circulating free heme and pro-inflammatory cytokines and chemokines, brain ...
Cespedes, Juan Carlos, Ford, Byron, Liu, Mingli, Solomon, Wesley, Stiles, Jonathan K, Wilson, Nana O   +5 more
core   +1 more source

Genetic and genomic approaches for the discovery of parasite genes involved in antimalarial drug resistance [PDF]

, 2013
The biggest threat to the war on malaria is the continued evolution of drug resistance by the parasite. Resistance to almost all currently available antimalarials now exists in Plasmodium falciparum which causes the most suffering among all human malaria
Mwangi, J.M., Ranford-Cartwright, L.C.
core   +1 more source

Disruption of Parasite hmgb2 Gene Attenuates Plasmodium berghei ANKA Pathogenicity [PDF]

, 2015
Eukaryotic high-mobility-group-box (HMGB) proteins are nuclear factors involved in chromatin remodeling and transcription regulation. When released into the extracellular milieu, HMGB1 acts as a proinflammatory cytokine that plays a central role in the ...
Abdullah S, Andersson U, Grau GE, Hori O, Kaul DK, Kaul DK, Li J, Naglova H, Paxinos G, Ronfani L, WHO, Yang R   +11 more
core   +1 more source

Ajuvant effect of a Synthetic Aluminium - Magnesium Silicate on chloroquine phosphate, against Plasmodium berghei. [PDF]

, 2012
effect of a synthetic Aluminium - Magnesium Silicate (AMS) on antiplasmodial activity of chloroquine was tested. Plasmodium berghei-infected mice were treated with 7 mg/kg, 5 mg/kg and 3 mg/kg chloroquine, respectively.
Augustine Ngene, madike ezeibe, nnenna elendu-eleke, obianuju obianuju Okoroafor   +3 more
core   +2 more sources

Antiplasmodial Effect of Anthocleista vogelii on Albino Mice Experimentally Infected with Plasmodium berghei berghei (NK 65)

Journal of Parasitology Research, 2014
The objective of the present study was to investigate the antiplasmodial effect of the ethanolic stem bark extract of Anthocleista vogelii at different doses in albino mice infected with Plasmodium berghei berghei (NK 65).
Lebari Barine Gboeloh, Okpok Eta Okon, Samuel Effiong Udoh   +2 more
doaj   +1 more source