Results 91 to 100 of about 107,407 (254)

Extracellular ATP triggers proteolysis and cytosolic Ca²⁺ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites

Malaria Journal, 2012
Background Plasmodium has a complex cell biology and it is essential to dissect the cell-signalling pathways underlying its survival within the host. Methods Using the fluorescence resonance energy transfer (FRET) peptide substrate Abz-AIKFFARQ-EDDnp and
Cruz Laura, Juliano Maria, Budu Alexandre, Juliano Luiz, Holder Anthony A, Blackman Michael J, Garcia Célia RS   +6 more
doaj   +1 more source

A perforin‐like protein mediates disruption of the erythrocyte membrane during egress of Plasmodium berghei male gametocytes

Cellular Microbiology, 2013
Successful gametogenesis of the malaria parasite depends on egress of the gametocytes from the erythrocytes within which they developed. Egress entails rupture of both the parasitophorous vacuole membrane and the erythrocyte plasma membrane, and precedes
E. Deligianni, Rhiannon N Morgan, L. Bertuccini, C. C. Wirth, Natalie C. Silmon de Monerri, L. Spanos, M. Blackman, C. Louis, G. Pradel, I. Sidén-Kiamos   +9 more
semanticscholar   +1 more source

The Immunomodulatory Role of Estrogen in Malaria: A Review of Sex Differences and Therapeutic Implications

Immunity, Inflammation and Disease, Volume 13, Issue 2, February 2025.
1. The present review highlights the significant sexual dimorphism in malaria, where males exhibit more severe symptoms and higher mortality rates compared to females, underscoring the need to incorporate gender factors in malaria research. 2. The present review emphasizes the role of estrogen in modulating immune responses to malaria, suggesting that ...
Ye Wu, Ying‐Chun Chen, Fang‐Fang Liu, Ke Li   +3 more
wiley   +1 more source

In Vitro and In Vivo Antimalarial Activity of LZ1, a Peptide Derived from Snake Cathelicidin

Toxins, 2019
Antimalarial drug resistance is an enormous global threat. Recently, antimicrobial peptides (AMPs) are emerging as a new source of antimalarials. In this study, an AMP LZ1 derived from snake cathelicidin was identified with antimalarial activity.
Yaqun Fang, Xiaoqin He, Pengcheng Zhang, Chuanbin Shen, James Mwangi, Cheng Xu, Guoxiang Mo, Ren Lai, Zhiye Zhang   +8 more
doaj   +1 more source

Expanding the transgene expression toolbox of the malaria vector Anopheles stephensi

Insect Molecular Biology, Volume 34, Issue 1, Page 104-110, February 2025.
An. stephensi lipophorin (lp) gene fragment drives expression of the ZsYellow marker protein in the fat body of aquatic and adult life stages of An. stephensi validating its utility for expression in these tissues. The lp‐driven expression is distinguishable from the commonly utilised 3xP3 promoter, suggesting that both promoters could be used ...
Joshua Southworth, Estela Gonzalez, Katherine Nevard, Mireia Larrosa‐Godall, Luke Alphey, Michelle A. E. Anderson   +5 more
wiley   +1 more source

Click Coupling of Flavylium Dyes with Plasmodione Analogues: Towards New Redox‐Sensitive Pro‐Fluorophores

Chemistry – A European Journal, Volume 31, Issue 6, January 27, 2025.
Redox‐sensitive pro‐fluorophores based on azido‐flavyliums clicked to alkynyl analogues of plasmodione oxide have been developed. In their quinone form, the fluorescence is quenched by photoinduced electron process (PeT) and restored after reducing to hydroquinone. PEG chain length modulates the amplitude of fluorogenic response.
Baptiste Dupouy, Leandro Cotos, Annika Binder, Lucie Slavikova, Matthias Rottmann, Pascal Mäser, Denis Jacquemin, Markus Ganter, Elisabeth Davioud‐Charvet, Mourad Elhabiri   +9 more
wiley   +1 more source

Structure of Plasmodium vivaxN‐myristoyltransferase with inhibitor IMP‐1088: exploring an NMT inhibitor for antimalarial therapy

Acta Crystallographica Section F, Volume 81, Issue 1, Page 1-10, January 2025.
The 1.8 Å resolution ternary structure of P. vivaxN‐myristoyltransferase in complex with IMP‐1088 and myristoyl‐CoA is presented. IMP‐1088 is an N‐myristoyltransferase inhibitor from a family of inhibitors that are under investigation as antimalarials.Plasmodium vivax, a significant contributor to global malaria cases, poses an escalating health burden
Alex Mendez, Cydni Bolling, Shane Taylor, Stanley Makumire, Bart Staker, Alexandra Reers, Brad Hammerson, Stephen J. Mayclin, Jan Abendroth, Donald D. Lorimer, Thomas E. Edwards, Edward W. Tate, Sandhya Subramanian, Andrew S. Bell, Peter J. Myler, Oluwatoyin A. Asojo, Graham Chakafana   +16 more
wiley   +1 more source

Efficacy of a Plasmodium vivax Malaria Vaccine Using ChAd63 and Modified Vaccinia Ankara Expressing Thrombospondin-Related Anonymous Protein as Assessed with Transgenic Plasmodium berghei Parasites

Infection and Immunity, 2013
Plasmodium vivax is the world's most widely distributed malaria parasite and a potential cause of morbidity and mortality for approximately 2.85 billion people living mainly in Southeast Asia and Latin America.
Karolis Bauza, T. Malinauskas, Claudia Pfander, B. Anar, E. Jones, O. Billker, A. Hill, A. Reyes‐Sandoval   +7 more
semanticscholar   +1 more source

The Curative and Prophylactic Effects of Xylopic Acid on Plasmodium berghei Infection in Mice

Journal of Parasitology Research, 2013
Efforts have been intensified to search for more effective antimalarial agents because of the observed failure of some artemisinin-based combination therapy (ACT) treatments of malaria in Ghana.
J. N. Boampong, E. Ameyaw, B. Aboagye, Kwame Kumi Asare, S. Kyei, J. Donfack, E. Woode   +6 more
semanticscholar   +1 more source

IL35 modulation altered survival, cytokine environment and histopathological consequences during malaria infection in mice

Malaria Journal, 2019
Background The immune modulating potential of IL-35 in multiple human disorders has been reported. Consequent upon the recognition of inflammatory cytokine activation and its preponderance for mediating pathology during malaria infection, the study aimed
Ramatu Omenesa Bello, Maizaton Atmadini Abdullah, Roslaini Abd Majid, Voon Kin Chin, Mohammed Faruq Abd Rachman Isnadi, Zaid Osama Ibraheem, Mohd Khairi Hussain, Mohammed Garba Magaji, Rusliza Basir   +8 more
doaj   +1 more source