Results 11 to 20 of about 17,618 (180)

A Plasmodium falciparum host-targeting motif functions in export during blood stage infection of the rodent malarial parasite Plasmodium berghei. [PDF]

PLoS ONE, 2008
Plasmodium falciparum (P. falciparum) secretes hundreds of proteins--including major virulence proteins--into the host erythrocyte. In order to reach the host cytoplasm, most P. falciparum proteins contain an N terminal host-targeting (HT) motif composed
Julia J MacKenzie, Noé D Gómez, Souvik Bhattacharjee, Shaina Mann, Kasturi Haldar   +4 more
doaj   +1 more source

Repurposing Dihydroartemisinin-Piperaquine-Doxycycline as an Antimalarial Drug: A Study in Plasmodium berghei-Infected Mice

Biology, Medicine & Natural Product Chemistry, 2021
Artemisinin-based combination (ACT) therapy is the mainstay for malaria treatment. However, Plasmodium parasite with decreased susceptibility to ACT has emerged.
Udeme Owunari Georgewill, Elias Adikwu
doaj   +1 more source

Anopheles gambiae immune responses to human and rodent Plasmodium parasite species. [PDF]

PLoS Pathogens, 2006
Transmission of malaria is dependent on the successful completion of the Plasmodium lifecycle in the Anopheles vector. Major obstacles are encountered in the midgut tissue, where most parasites are killed by the mosquito's immune system.
Yuemei Dong, Ruth Aguilar, Zhiyong Xi, Emma Warr, Emmanuel Mongin, George Dimopoulos   +5 more
doaj   +1 more source

Reproductive indices in malaria infested mice treated with antimalarials, Phyllanthus amarus combined with vitamins

Bulletin of Faculty of Pharmacy Cairo University, 2018
Malaria disease is caused by the plasmodium organism transmitted into humans by the female anopheles mosquito. The effect of chloroquine, artesunate or Phyllantus amarus alone or combined with vitamins A, B, C or K on male fertility indices has received ...
Matthew Obaineh Ojezele, Ighodaro Igbe, Agbonlahor Okhuarobo   +2 more
doaj   +1 more source

Using green fluorescent malaria parasites to screen for permissive vector mosquitoes

Malaria Journal, 2006
Background The Plasmodium species that infect rodents, particularly Plasmodium berghei and Plasmodium yoelii, are useful to investigate host-parasite interactions. The mosquito species that act as vectors of human plasmodia in South East Asia, Africa and
Martin Beatrice, Frischknecht Friedrich, Thiery Isabelle, Bourgouin Catherine, Menard Robert   +4 more
doaj   +1 more source

Ecology of asynchronous asexual replication: the intraerythrocytic development cycle of Plasmodium berghei is resistant to host rhythms

Malaria Journal, 2021
Background Daily periodicity in the diverse activities of parasites occurs across a broad taxonomic range. The rhythms exhibited by parasites are thought to be adaptations that allow parasites to cope with, or exploit, the consequences of host activities
Aidan J. O’Donnell, Sarah E. Reece
doaj   +1 more source

Amodiaquine resistance in Plasmodium berghei is associated with PbCRT His95Pro mutation, loss of chloroquine, artemisinin and primaquine sensitivity, and high transcript levels of key transporters [version 2; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2018
Background: The human malaria parasite Plasmodium falciparum has evolved drug evasion mechanisms to all available antimalarials. The combination of amodiaquine-artesunate is among the drug of choice for treatment of uncomplicated malaria.
Loise Ndung'u, Benard Langat, Esther Magiri, Joseph Ng'ang'a, Beatrice Irungu, Alexis Nzila, Daniel Kiboi   +6 more
doaj   +1 more source

Effects of Moringa oleifera Extract as an Immunomodulator of Lymphocyte Cells and Macrophages in BALB/c Mice Infected with Plasmodium berghei

Folia Medica Indonesiana, 2023
Highlights: 1. This study assessed the immunomodulatory potential of Moringa oleifera, which may serve as a natural source for antimalarial treatment. 2.
Putu Khrisna Dharma Jaya, Putu Indah Budi Apsari, Pande Made Alitta Cantika Putri Nadya Dewi, Dewa Ayu Agus Sri Laksemi, I Ketut Cahyadi Adi Winata Sutarta   +4 more
doaj   +1 more source

Continuous exposure to Plasmodium results in decreased susceptibility and transcriptomic divergence of the Anopheles gambiae immune system

BMC Genomics, 2007
Background Plasmodium infection has been shown to compromise the fitness of the mosquito vector, reducing its fecundity and longevity. However, from an evolutionary perspective, the impact of Plasmodium infection as a selective pressure on the mosquito ...
Dimopoulos George, Dong Yuemei, Das Suchismita, Aguilar Ruth   +3 more
doaj   +1 more source

Structural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2

eLife, 2021
HAP2 is a transmembrane gamete fusogen found in multiple eukaryotic kingdoms and is structurally homologous to viral class II fusogens. Studies in Plasmodium have suggested that HAP2 is an attractive target for vaccines that block transmission of malaria.
Juan Feng, Xianchi Dong, Adam DeCosta, Yang Su, Fiona Angrisano, Katarzyna A Sala, Andrew M Blagborough, Chafen Lu, Timothy A Springer   +8 more
doaj   +1 more source