Transcriptome analysis reveals a de novo DNA element that may interact with chromatin-associated proteins in Plasmodium berghei during erythrocytic development [PDF]
Scientific ReportsThe life cycle of Plasmodium parasites involves intricate, multistage processes that are tightly regulated by stage-specific transcription factors. These factors bind to regulatory regions within gene promoters, enabling the precise expression of genes ...
Adaobi Okafor +3 more
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CSP ubiquitylation favours Plasmodium berghei survival during early liver stage infection [PDF]
Scientific ReportsThe circumsporozoite protein (CSP), an essential protein that covers the surface of the Plasmodium sporozoite, is a key player in multiple stages of the parasite development within the mosquito and during interactions between sporozoites and mammalian ...
Sara J. S. Baptista +7 more
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Constitutive expression of Cas9 and rapamycin-inducible Cre recombinase facilitates conditional genome editing in Plasmodium berghei [PDF]
Scientific ReportsMalaria is caused by protozoan parasites of the genus Plasmodium and remains a global health concern. The parasite has a highly adaptable life cycle comprising successive rounds of asexual replication in a vertebrate host and sexual maturation in the ...
Samhita Das +10 more
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The phosphatase inhibitor BVT-948 can be used to efficiently screen functional sexual development proteins in the malaria parasite Plasmodium berghei [PDF]
International Journal for Parasitology: Drugs and Drug ResistanceBackground: Studying and discovering the molecular mechanism of Plasmodium sexual development is crucial for the development of transmission blocking drugs and malaria eradication.
Xitong Jia +9 more
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Molecular Ecology, EarlyView., 2023 Abstract Malaria is a mosquito‐borne disease caused by protozoans of the genus Plasmodium that affects both humans and wildlife. The fitness consequences of infections by avian malaria are well known in birds, however, little information exists on its impact on mosquitoes.
Marta Garrigós +4 more
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Anopheles gambiae immune responses to human and rodent Plasmodium parasite species. [PDF]
PLoS Pathogens, 2006 Transmission of malaria is dependent on the successful completion of the Plasmodium lifecycle in the Anopheles vector. Major obstacles are encountered in the midgut tissue, where most parasites are killed by the mosquito's immune system.
Yuemei Dong +5 more
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A Plasmodium falciparum host-targeting motif functions in export during blood stage infection of the rodent malarial parasite Plasmodium berghei. [PDF]
PLoS ONE, 2008 Plasmodium falciparum (P. falciparum) secretes hundreds of proteins--including major virulence proteins--into the host erythrocyte. In order to reach the host cytoplasm, most P. falciparum proteins contain an N terminal host-targeting (HT) motif composed
Julia J MacKenzie +4 more
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Sequestration and tissue accumulation of human malaria parasites: can we learn anything from rodent models of malaria? [PDF]
PLoS Pathogens, 2010 The sequestration of Plasmodium falciparum-infected red blood cells (irbcs) in the microvasculature of organs is associated with severe disease; correspondingly, the molecular basis of irbc adherence is an active area of study.
Blandine Franke-Fayard +4 more
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Using green fluorescent malaria parasites to screen for permissive vector mosquitoes
Malaria Journal, 2006 Background The Plasmodium species that infect rodents, particularly Plasmodium berghei and Plasmodium yoelii, are useful to investigate host-parasite interactions. The mosquito species that act as vectors of human plasmodia in South East Asia, Africa and
Martin Beatrice +4 more
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Malaria Journal, 2021 Background Daily periodicity in the diverse activities of parasites occurs across a broad taxonomic range. The rhythms exhibited by parasites are thought to be adaptations that allow parasites to cope with, or exploit, the consequences of host activities
Aidan J. O’Donnell, Sarah E. Reece
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