Results 21 to 30 of about 107,407 (254)

Structural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2

eLife, 2021
HAP2 is a transmembrane gamete fusogen found in multiple eukaryotic kingdoms and is structurally homologous to viral class II fusogens. Studies in Plasmodium have suggested that HAP2 is an attractive target for vaccines that block transmission of malaria.
Juan Feng, Xianchi Dong, Adam DeCosta, Yang Su, Fiona Angrisano, Katarzyna A Sala, Andrew M Blagborough, Chafen Lu, Timothy A Springer   +8 more
doaj   +1 more source

Amodiaquine resistance in Plasmodium berghei is associated with PbCRT His95Pro mutation, loss of chloroquine, artemisinin and primaquine sensitivity, and high transcript levels of key transporters [version 2; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2018
Background: The human malaria parasite Plasmodium falciparum has evolved drug evasion mechanisms to all available antimalarials. The combination of amodiaquine-artesunate is among the drug of choice for treatment of uncomplicated malaria.
Loise Ndung'u, Benard Langat, Esther Magiri, Joseph Ng'ang'a, Beatrice Irungu, Alexis Nzila, Daniel Kiboi   +6 more
doaj   +1 more source

Inducible developmental reprogramming redefines commitment to sexual development in the malaria parasite Plasmodium berghei

Nature Microbiology, 2018
During malaria infection, Plasmodium spp. parasites cyclically invade red blood cells and can follow two different developmental pathways. They can either replicate asexually to sustain the infection, or differentiate into gametocytes, the sexual stage ...
Robyn S. Kent, Katarzyna K. Modrzynska, R. Cameron, N. Philip, O. Billker, A. Waters   +5 more
semanticscholar   +1 more source

Transcriptome analysis of Plasmodium berghei during exo-erythrocytic development

Malaria Journal, 2019
The complex life cycle of malaria parasites requires well-orchestrated stage specific gene expression. In the vertebrate host the parasites grow and multiply by schizogony in two different environments: within erythrocytes and within hepatocytes. Whereas
R. Caldelari, S. Dogga, M. Schmid, B. Franke-Fayard, C. Janse, Dominique Soldati-Favre, V. Heussler   +6 more
semanticscholar   +1 more source

Effects of Moringa oleifera Extract as an Immunomodulator of Lymphocyte Cells and Macrophages in BALB/c Mice Infected with Plasmodium berghei

Folia Medica Indonesiana, 2023
Highlights: 1. This study assessed the immunomodulatory potential of Moringa oleifera, which may serve as a natural source for antimalarial treatment. 2.
Putu Khrisna Dharma Jaya, Putu Indah Budi Apsari, Pande Made Alitta Cantika Putri Nadya Dewi, Dewa Ayu Agus Sri Laksemi, I Ketut Cahyadi Adi Winata Sutarta   +4 more
doaj   +1 more source

Antimalarial Activity of Kaempferol and Its Combination with Chloroquine in Plasmodium berghei Infection in Mice

Journal of Pathogens, 2018
The search for new antimalarial drugs has become an urgent requirement due to resistance to the available drugs and the lack of an effective vaccine. In this respect, the present study aimed to evaluate the antimalarial activity of kaempferol against ...
Voravuth Somsak, Awatsada Damkaew, Pinanong Onrak   +2 more
semanticscholar   +1 more source

Continuous exposure to Plasmodium results in decreased susceptibility and transcriptomic divergence of the Anopheles gambiae immune system

BMC Genomics, 2007
Background Plasmodium infection has been shown to compromise the fitness of the mosquito vector, reducing its fecundity and longevity. However, from an evolutionary perspective, the impact of Plasmodium infection as a selective pressure on the mosquito ...
Dimopoulos George, Dong Yuemei, Das Suchismita, Aguilar Ruth   +3 more
doaj   +1 more source

Killer yeasts exert anti-plasmodial activities against the malaria parasite Plasmodium berghei in the vector mosquito Anopheles stephensi and in mice

Parasites & Vectors, 2019
Wickerhamomyces anomalus is a yeast associated with different insects including mosquitoes, where it is proposed to be involved in symbiotic relationships with hosts. Different symbiotic strains of W.
A. Cappelli, M. Valzano, V. Cecarini, J. Bozic, P. Rossi, Priscilla Mensah, C. Amantini, G. Favia, I. Ricci   +8 more
semanticscholar   +1 more source

Ethanol Root-extract of Sphenocentrum jollyanum Restored Altered Haematological Markers in Plasmodium berghei-infected Mice

Earthline Journal of Chemical Sciences, 2019
Effect of ethanol root-extract of Sphenocentrum jollyanum on some haematological parameters in Plasmodium berghei-infected mice was carried out using a total of thirty-six albino mice.
E. U. Ekpono, P. M. Aja, U. Ibiam, E. Alum, U. E. Ekpono   +4 more
semanticscholar   +1 more source

EFEKTIVITAS PEMBERIAN NANOPARTIKEL EKSTRAK DAUN JUWET (Syzygium cumini) SEBAGAI ADJUVANT TERAPI TERHADAP GAMBARANHISTOPATOLOGI PULMO MENCIT (Mus musculus) YANG DIINFEKSI Plasmodium bhergei

Journal of Basic Medical Veterinary, 2020
The purpose of this study was to learn how to use juwet nanoparticle leaf extract (Syzygium cumini) as an adjunct therapy in pulmonary histopathological mice (Mus musculus) supported by Plasmodium berghei.
Zerlinda Dyah Ayu, Lilik Maslachah, Koesnoto Supranianondo, Endang Suprihati, Hani Plumeriastuti, Rahmi Sugihartuti   +5 more
doaj   +1 more source