Results 31 to 40 of about 107,407 (254)

A member of the tryptophan-rich protein family is required for efficient sequestration of Plasmodium berghei schizonts.

PLoS Pathogens, 2022
Protein export and host membrane remodeling are crucial for multiple Plasmodium species to establish a niche in infected hosts. To better understand the contribution of these processes to successful parasite infection in vivo, we sought to find and ...
Julie-Anne Gabelich, Josephine Grützke, Florian Kirscht, Oliver Popp, Joachim M Matz, Gunnar Dittmar, Melanie Rug, Alyssa Ingmundson   +7 more
doaj   +1 more source

Influence of midgut microbiota in Anopheles stephensi on Plasmodium berghei infections

Malaria Journal, 2018
The native gut microbiota of Anopheles mosquitoes is known to play a key role in the physiological function of its host. Interestingly, this microbiota can also influence the development of Plasmodium in its host mosquitoes.
D. Kalappa, P. A. Subramani, S. K. Basavanna, S. Ghosh, V. Sundaramurthy, Sreehari Uragayala, S. Tiwari, A. Anvikar, N. Valecha   +8 more
semanticscholar   +1 more source

Plasmodium berghei K13 Mutations Mediate In Vivo Artemisinin Resistance That Is Reversed by Proteasome Inhibition

mBio, 2020
The recent emergence of Plasmodium falciparum parasite resistance to the first line antimalarial drug artemisinin is of particular concern. Artemisinin resistance is primarily driven by mutations in the P.
Nelson V. Simwela, Barbara H. Stokes, Dana Aghabi, Matt Bogyo, David A. Fidock, Andrew P. Waters   +5 more
doaj   +1 more source

Uji Aktivitas Antimalaria dari Spons Xestospongia sp. Asal Pulau Yapen secara In Vivo

Jurnal Kelautan Tropis, 2021
It is generally admitted that marine sponge has rich of secondary metabolite as alkaloids, peptides and terpene. Those various compounds can be used for antimalarial drug.  This study aims to evaluate the in vivo antimalarial activity and to characterize
Murtihapsari Murtihapsari, Mathelda K. Roreng, Apriani Parubak, Alif Rahman   +3 more
doaj   +1 more source

Evaluation of Antimalarial Activity of the Leaf Latex and TLC Isolates from Aloe megalacantha Baker in Plasmodium berghei Infected Mice

Evidence-Based Complementary and Alternative Medicine, 2019
Malaria is a devastating parasitic disease which caused around 216 million cases and 445,000 deaths worldwide in 2016. This might be attributed to a wide spread of drug resistant parasites.
Gebretsadkan Hintsa, G. Sibhat, Aman Karim   +2 more
semanticscholar   +1 more source

The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4‐Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria

Angewandte Chemie, EarlyView.
AZD0156, an ATM kinase inhibitor in clinical development, shows promising multistage antiplasmodial activity by targeting Plasmodium falciparum phosphatidylinositol 4‐kinase (PfPI4Kβ). With an improved specificity profile relative to other PfPI4Kβ inhibitors and moderate efficacy in a P.
John G. Woodland, Dina Coertzen, Kathryn J. Wicht, Virginia Franco Hidalgo, Charisse Flerida A. Pasaje, Luiz C. Godoy, Tarrick Qahash, Mmakwena M. Mmonwa, Godwin A. Dziwornu, Lynn Wambua, Sarah Harries, Constance M. Korkor, Mathew Njoroge, Liezl Krugmann, Dale Taylor, Meta Leshabane, Henrico Langeveld, Tayla Rabie, Janette Reader, Mariëtte van der Watt, Nelius Venter, Erica Erlank, Ayesha S. Aswat, Lizette L. Koekemoer, Tomas Yeo, Jin H. Jeon, David A. Fidock, Francisco Javier Gamo, Sergio Wittlin, Jacquin C. Niles, Manuel Llinas, Lauren B. Coulson, Lyn‐Marié Birkholtz, Kelly Chibale   +33 more
wiley   +2 more sources

Extract of Morinda lucida leaf rescues hypoglycaemic and dyslipidaemic conditions in Plasmodium berghei-infected mice [PDF]

Bulletin of Natural Sciences Research, 2022
Increasing drug resistance is a great threat to malaria control. Therefore, a continuous investigation into alternative therapy to mitigate malaria-associated damages is important.
Abdulkareem Adam Olaitan, Babamale Abdulkareem Olarewaju, Anifowoshe Abass Toba, Opeyemi Olufunke Adenike Opeyemi Olufunke Adenike, Oloriegbe Nusirat, Adamolekun Comfort, Adetula Samson, Ala Adeola Adefoluke   +7 more
doaj   +1 more source

Differential induction of malaria liver pathology in mice infected with Plasmodium chabaudi AS or Plasmodium berghei NK65

Malaria Journal, 2018
Cerebral malaria and severe anaemia are the most common deadly complications of malaria, and are often associated, both in paediatric and adult patients, with hepatopathy, whose pathogenesis is not well characterized, and sometimes also with acute ...
D. Scaccabarozzi, K. Deroost, Y. Corbett, Natacha Lays, P. Corsetto, F. O. Salè, P. E. Van den Steen, D. Taramelli   +7 more
semanticscholar   +1 more source

Synthesis of Chirally Chimeric Protein Nanoparticle Vaccines via Mirror‐Image Spy Chemistry

Angewandte Chemie, EarlyView.
This study illustrates a versatile strategy for creating chirally chimeric protein constructs by merging natural‐chirality (L‐) and mirror‐image (D‐) protein motifs through a combination of L‐sortase‐mediated transpeptidation and D‐SpyStapler‐mediated ligation.
Songzi Kou, Chenbo Sun, Weitao Chen, Hanyu Gao, Fei Sun   +4 more
wiley   +2 more sources

Altered Lipid Composition of Surfactant and Lung Tissue in Murine Experimental Malaria-Associated Acute Respiratory Distress Syndrome. [PDF]

PLoS ONE, 2015
Malaria-associated acute lung injury (MA-ALI) and its more severe form malaria-associated acute respiratory distress syndrome (MA-ARDS) are common, often fatal complications of severe malaria infections. However, little is known about their pathogenesis.
Diletta Scaccabarozzi, Katrien Deroost, Natacha Lays, Fausta Omodeo Salè, Philippe E Van den Steen, Donatella Taramelli   +5 more
doaj   +1 more source