Results 41 to 50 of about 17,618 (180)

Optimisation of freeze substitution protocols for the examination of malaria parasite structure by volumetric electron microscopy

Journal of Microscopy, EarlyView.
Abstract Malaria is one of the deadliest infectious diseases in the world, annually responsible for over 400,000 deaths. It is caused by parasites of the genus Plasmodium, which undergo remarkable structural changes during their development within different cells across various hosts.
Rachel Rachid, Camila Wendt, Wanderley de Souza, Kildare Miranda   +3 more
wiley   +1 more source

Targeting Aurora Kinases as Essential Cell‐Cycle Regulators to Deliver Multi‐Stage Antimalarials Against Plasmodium Falciparum

Angewandte Chemie, Volume 137, Issue 51, December 15, 2025.
In this study, we repurposed human Aurora kinase‐specific inhibitors to identify potential antimalarial agents. Two inhibitors, hesperadin and TAE684, exhibited sub‐micromolar activity across multiple parasite stages, with hesperadin demonstrating significant potency and selectivity by specifically targeting PfArk1.
Henrico Langeveld, Keletso Maepa, Marché Maree, Jessica L. Thibaud, Nicolaas Salomane, Rosie Bridgwater, Mufuliat T. Famodimu, Luiz C. Godoy, Charisse Flerida A. Pasaje, Nonlawat Boonyalai, Mariana Laureano de Souza, Justin Fong, Tayla Rabie, Mariëtte van der Watt, Rensu P. Theart, Sonja Ghidelli‐Disse, Jacquin C. Niles, Marcus C. S. Lee, Elizabeth A. Winzeler, Michael J. Delves, Kelly Chibale, Kathryn J. Wicht, Lauren B. Coulson, Lyn‐Marié Birkholtz   +23 more
wiley   +2 more sources

Plasmodium berghei calcium dependent protein kinase 1 is not required for host cell invasion. [PDF]

PLoS ONE, 2013
Plasmodium Calcium Dependent Protein Kinase (CDPK1) is required for the development of sexual stages in the mosquito. In addition, it is proposed to play an essential role in the parasite's invasive stages possibly through the regulation of the ...
Sylvia Jebiwott, Kavitha Govindaswamy, Amos Mbugua, Purnima Bhanot   +3 more
doaj   +1 more source

Gambaran Histopatologi Hepar Mencit (Mus musculus Balb/C) yang Diinfeksi dengan Plasmodium berghei

Jurnal Ilmu Kesehatan Indonesia, 2022
Background: The most common cause of death by malaria in Indonesia is Plasmodium falciparum, which is analogous to Plasmodium berghei, which lives as a parasite in the liver of mice.
Hanifah Putri Dwiridal, Adrial Adrial, Eryati Darwin   +2 more
doaj   +1 more source

Traction force generation in Plasmodium sporozoites is modulated by a surface adhesin

Journal of Microscopy, EarlyView.
Abstract Plasmodium sporozoites are the highly polarised and motile forms of the malaria parasite transmitted by mosquitoes to the vertebrate hosts. Sporozoites use myosin motors to generate retrograde flow of actin filaments. These are linked to plasma membrane spanning adhesins, which in turn bind to the extracellular environment, resulting in ...
Johanna Ripp, Dimitri Probst, Mirko Singer, Ulrich S. Schwarz, Friedrich Frischknecht   +4 more
wiley   +1 more source

Erythrocyte Membrane Protein 3 (EMAP3) Is Exposed on the Surface of the Plasmodium berghei Infected Red Blood Cell

Molecular Microbiology, EarlyView.
Erythrocyte membrane protein 3 (EMAP3) is a novel Plasmodium berghei protein that is trafficked to the outer membrane surface of the infected red blood cell (iRBC). EMAP3 is not critical for parasite growth or sequestration but offers a new scaffold for displaying Plasmodium falciparum proteins on iRBCs.
Sophia Raine C. Hernandez, Ravish Rashpa, Thorey K. Jonsdottir, Martina S. Paoletta, Josy ter Beek, María Rayón Díaz, Jelte M. M. Krol, Severine Chevalley‐Maurel, Takahiro Ishizaki, Ronnie P.‐A. Berntsson, Chris J. Janse, Blandine Franke‐Fayard, Mathieu Brochet, Ellen S. C. Bushell   +13 more
wiley   +1 more source

Unravelling the biochemical aspects of the interaction between ticks and Leishmania using a tick cell line

Medical and Veterinary Entomology, EarlyView.
Leishmania infantum propagated in IDE8 tick cell line in vitro. L. infantum reduces tick cell viability and induces reactive oxygen species production. Lipidic profile of IDE8 tick cell line is altered during Leishmania infection. Abstract Leishmaniasis comprises a group of vector‐borne neglected tropical diseases caused by species of the obligatory ...
Beatriz Filgueiras Silvestre, Karoline dos Anjos Lima, Fernanda de Paula Pepino, Daniela Cosentino‐Gomes, Adivaldo Fonseca, Lesley Bell‐Sakyi, Georgia Correa Atella, Lucia H. Pinto‐da‐Silva   +7 more
wiley   +1 more source

MOLECULAR ANALYSIS OF PBMSP-1 GENE IN ERYTHROCYTE OF MICE INFECTED WITH Plasmodium berghei

Jurnal Kedokteran Hewan, 2018
This study aimed to analyze MSP-1 gene in mice erythrocyte infected with Plasmodium berghei using polymerase chain reaction (PCR). The result showed the existence of 462 bp DNA band which was assumed to encode MSP-1 protein with molecular weight of 19 ...
Rosnizar Rosnizar, Kartini Eriani
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, Volume 600, Issue 2, Page 251-266, January 2026.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

HaloPROTAC3 does not trigger the degradation of the halotagged parasitophorous vacuole membrane protein UIS4 during Plasmodium liver stage development

Scientific Reports
Targeted protein degradation (TPD) is a novel strategy for developing therapeutics against pathogens. Prior to causing malaria, Plasmodium parasites replicate within hepatocytes as liver stages, surrounded by a parasitophorous vacuole membrane (PVM).
Melanie Lam, Alexandra Probst, Laura Torres, Ashley A. Lantigua, Matthew E. Fishbaugher, Jyothsna R. Kumar, Manuel Saldivia, Allison Torres, Shreeya Hegde, Maya Aleshnick, Charlie Jennison, Sarah G. H. Roberson, Chester J. Joyner, Ashley M. Vaughan, Brandon K. Wilder, Carole Manneville, Erika L. Flannery, David Marcellin, Beat Nyfeler, Zacharias Thiel, Sebastian A. Mikolajczak, Anke Harupa, Gabriel Mitchell   +22 more
doaj   +1 more source