Rapid and Specific Action of Methylene Blue against Plasmodium Transmission Stages
Methylene blue (MB) is the oldest synthetic anti-infective. Its high potency against asexual and sexual stages of malaria parasites is well documented.
Nathanaël Saison+12 more
doaj +1 more source
Rocaglates as dual-targeting agents for experimental cerebral malaria [PDF]
Cerebral malaria (CM) is a severe and rapidly progressing complication of infection by Plasmodium parasites that is associated with high rates of mortality and morbidity.
Ayi, Kodjo+12 more
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Cortisone and Plasmodium berghei Infection in Mice [PDF]
THERE is considerable clinical evidence to show that in persons infected with malaria various stimuli may precipitate an acute attack. These stimuli include surgical operations, the injection of vaccines, exposure to cold, and possibly, for persons who have not become acclimatized, ascent to high altitudes.
G. M. Findlay, E. M. Howard
openaire +3 more sources
Generation of transgenic rodent malaria parasites by transfection of cell culture-derived merozoites
Background Malaria research is greatly dependent on and has drastically advanced with the possibility of genetically modifying Plasmodium parasites. The commonly used transfection protocol by Janse and colleagues utilizes blood stage-derived Plasmodium ...
Gesine Kaiser+5 more
doaj +1 more source
Ecological immunology of mosquito-malaria interactions: Of non-natural versus natural model systems and their inferences [PDF]
There has been a recent shift in the literature on mosquito/Plasmodium interactions with an increasingly large number of theoretical and experimental studies focusing on their population biology and evolutionary processes.
Tripet, F
core +1 more source
Genetic recombination in Plasmodium berghei
Crosses have been made between two lines of Plasmodium berghei yoelii differing in drug-sensitivity and enzyme-type. The two lines used were line A, which is pyrimethamine-resistant and contains an electrophoretic form of glucose phosphate isomerase termed GPI-1, and line C, which is pyrimethamine-sensitive and contains enzyme-form GPI-2. Equal numbers
S. Morgan+2 more
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The Plasmodium falciparum, Nima-related kinase Pfnek-4: a marker for asexual parasites committed to sexual differentiation [PDF]
<b>Background</b> Malaria parasites undergo, in the vertebrate host, a developmental switch from asexual replication to sexual differentiation leading to the formation of gametocytes, the only form able to survive in the mosquito vector ...
AG Maier+27 more
core +5 more sources
Chromosome translocation inPlasmodium berghei
We describe a chromosome translocation in a karyotype mutant of the rodent malarial parasite Plasmodium berghei. In this mutant (named EP) a small chromosome (chromosome 7), which has exhibited a size range between 0.9 and 1.4 Mb in other clones of P. berghei, is translocated to chromosome 13 or 14 with a size of about 3 Mb.
Chris J. Janse, Jai Ramesar, Barend Mons
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Loeki Enggar Fitri,1,2,* Agustina Tri Endharti,1 Hafshah Yasmina Abidah,3,4,* Alif Raudhah Husnul Khotimah,3,4,* Heni Endrawati1 1Department of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; 2Malaria Research ...
Fitri LE+4 more
doaj
Natural regulatory (CD4+CD25+FOXP+) T cells control the production of pro-inflammatory cytokines during Plasmodium chabaudi adami infection and do not contribute to immune evasion. [PDF]
Different functions have been attributed to natural regulatory CD4+CD25+FOXP+ (Treg) cells during malaria infection. Herein, we assessed the role for Treg cells during infections with lethal (DS) and non-lethal (DK) Plasmodium chabaudi adami parasites ...
Belanger, B+4 more
core +1 more source