Results 41 to 50 of about 107,407 (254)
BMC Genomics, 2017 The clinical symptoms of malaria are caused by the asexual replication of Plasmodium parasites in the blood of the vertebrate host. To spread to new hosts, however, the malaria parasite must differentiate into sexual forms, termed gametocytes, which are ...
L. M. Yeoh +4 more
semanticscholar +1 more source
A Plasmodium berghei sporozoite-based vaccination platform against human malaria
npj Vaccines, 2018 There is a pressing need for safe and highly effective Plasmodium falciparum (Pf) malaria vaccines. The circumsporozoite protein (CS), expressed on sporozoites and during early hepatic stages, is a leading target vaccine candidate, but clinical efficacy ...
A. Mendes +24 more
semanticscholar +1 more source
Suppression of experimental cerebral malaria by disruption of malate:quinone oxidoreductase
Malaria Journal, 2017 Background Aspartate, which is converted from oxaloacetate (OAA) by aspartate aminotransferase, is considered an important precursor for purine salvage and pyrimidine de novo biosynthesis, and is thus indispensable for the growth of Plasmodium parasites ...
Mamoru Niikura +7 more
doaj +1 more source
Molecular & Cellular Proteomics, 2016 Malaria transmission from an infected host to the mosquito vector requires the uptake of intraerythrocytic sexual precursor cells into the mosquito midgut. For the release of mature extracellular gametes two membrane barriers—the parasite parasitophorous
Jessica Kehrer, F. Frischknecht, G. Mair
semanticscholar +1 more source
Cortisone and Plasmodium berghei Infection in Mice [PDF]
Nature, 1952 THERE is considerable clinical evidence to show that in persons infected with malaria various stimuli may precipitate an acute attack. These stimuli include surgical operations, the injection of vaccines, exposure to cold, and possibly, for persons who have not become acclimatized, ascent to high altitudes.
G. M. Findlay, E. M. Howard
openaire +3 more sources
Cellular Microbiology, 2017 Eukaryotic cells can employ autophagy to defend themselves against invading pathogens. Upon infection by Plasmodium berghei sporozoites, the host hepatocyte targets the invader by labelling the parasitophorous vacuole membrane (PVM) with the autophagy ...
Rahel Wacker +7 more
semanticscholar +1 more source
Generation of transgenic rodent malaria parasites by transfection of cell culture-derived merozoites
Malaria Journal, 2017 Background Malaria research is greatly dependent on and has drastically advanced with the possibility of genetically modifying Plasmodium parasites. The commonly used transfection protocol by Janse and colleagues utilizes blood stage-derived Plasmodium ...
Gesine Kaiser +5 more
doaj +1 more source
Journal of Tropical Medicine, 2016 The study determined if administration of Vernonia amygdalina and Carica papaya plants provides synergistic effects in ameliorating plasmodium infection in mice. Thirty mice (17.88–25.3 g) were divided into 6 groups of 5 mice each.
O. Okpe +5 more
semanticscholar +1 more source
Infection and Drug Resistance, 2023 Loeki Enggar Fitri,1,2,* Agustina Tri Endharti,1 Hafshah Yasmina Abidah,3,4,* Alif Raudhah Husnul Khotimah,3,4,* Heni Endrawati1 1Department of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; 2Malaria Research ...
Fitri LE +4 more
doaj
Genetic recombination in Plasmodium berghei
Parasitology, 1973 Crosses have been made between two lines of Plasmodium berghei yoelii differing in drug-sensitivity and enzyme-type. The two lines used were line A, which is pyrimethamine-resistant and contains an electrophoretic form of glucose phosphate isomerase termed GPI-1, and line C, which is pyrimethamine-sensitive and contains enzyme-form GPI-2. Equal numbers
S. Morgan +2 more
openaire +3 more sources