Results 51 to 60 of about 124,584 (310)
A Plasmodium berghei sporozoite-based vaccination platform against human malaria
npj Vaccines, 2018 There is a pressing need for safe and highly effective Plasmodium falciparum (Pf) malaria vaccines. The circumsporozoite protein (CS), expressed on sporozoites and during early hepatic stages, is a leading target vaccine candidate, but clinical efficacy ...
A. Mendes +24 more
semanticscholar +1 more source
Rapid and Specific Action of Methylene Blue against Plasmodium Transmission Stages
Pharmaceutics, 2022 Methylene blue (MB) is the oldest synthetic anti-infective. Its high potency against asexual and sexual stages of malaria parasites is well documented.
Nathanaël Saison +12 more
doaj +1 more source
Molecular & Cellular Proteomics, 2016 Malaria transmission from an infected host to the mosquito vector requires the uptake of intraerythrocytic sexual precursor cells into the mosquito midgut. For the release of mature extracellular gametes two membrane barriers—the parasite parasitophorous
Jessica Kehrer, F. Frischknecht, G. Mair
semanticscholar +1 more source
Microstructured blood vessel surrogates reveal structural tropism of motile malaria parasites [PDF]
, 2017 Plasmodium sporozoites, the highly motile forms of the malaria parasite, are transmitted naturally by mosquitoes and traverse the skin to find, associate with, and enter blood capillaries.
Battista, Anna +11 more
core +1 more source
Cortisone and Plasmodium berghei Infection in Mice [PDF]
Nature, 1952 THERE is considerable clinical evidence to show that in persons infected with malaria various stimuli may precipitate an acute attack. These stimuli include surgical operations, the injection of vaccines, exposure to cold, and possibly, for persons who have not become acclimatized, ascent to high altitudes.
G. M. Findlay, E. M. Howard
openaire +3 more sources
Cellular Microbiology, 2017 Eukaryotic cells can employ autophagy to defend themselves against invading pathogens. Upon infection by Plasmodium berghei sporozoites, the host hepatocyte targets the invader by labelling the parasitophorous vacuole membrane (PVM) with the autophagy ...
Rahel Wacker +7 more
semanticscholar +1 more source
Generation of transgenic rodent malaria parasites by transfection of cell culture-derived merozoites
Malaria Journal, 2017 Background Malaria research is greatly dependent on and has drastically advanced with the possibility of genetically modifying Plasmodium parasites. The commonly used transfection protocol by Janse and colleagues utilizes blood stage-derived Plasmodium ...
Gesine Kaiser +5 more
doaj +1 more source
Genetic recombination in Plasmodium berghei
Parasitology, 1973 Crosses have been made between two lines of Plasmodium berghei yoelii differing in drug-sensitivity and enzyme-type. The two lines used were line A, which is pyrimethamine-resistant and contains an electrophoretic form of glucose phosphate isomerase termed GPI-1, and line C, which is pyrimethamine-sensitive and contains enzyme-form GPI-2. Equal numbers
S. Morgan +2 more
openaire +3 more sources
Rocaglates as dual-targeting agents for experimental cerebral malaria [PDF]
, 2018 Cerebral malaria (CM) is a severe and rapidly progressing complication of infection by Plasmodium parasites that is associated with high rates of mortality and morbidity.
Ayi, Kodjo +12 more
core +1 more source
The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. [PDF]
, 2002 Trypanosoma cruzi glutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, a parasite ...
Bromley, Elizabeth V +5 more
core +4 more sources