Results 61 to 70 of about 17,618 (180)

The phosphatase inhibitor BVT-948 can be used to efficiently screen functional sexual development proteins in the malaria parasite Plasmodium berghei

International Journal for Parasitology: Drugs and Drug Resistance
Background: Studying and discovering the molecular mechanism of Plasmodium sexual development is crucial for the development of transmission blocking drugs and malaria eradication.
Xitong Jia, Yong Wang, Meilian Wang, Hui Min, Zehou Fang, Haifeng Lu, Jiao Li, Yaming Cao, Lunhao Bai, Jinghan Lu   +9 more
doaj   +1 more source

Highly divergent apicomplexan cytoskeletons provide additional models for actin biology

The FEBS Journal, Volume 292, Issue 24, Page 6459-6480, December 2025.
Actin is a highly conserved, abundant and central molecule in eukaryotes. Apicomplexans contain some of the most sequence‐divergent actin cytoskeletons known. This divergence results in overlapping yet different biochemical properties. Here, we highlight the remarkable divergence of the actin cytoskeleton by comparing apicomplexan to classical systems,
Yukino Kobayashi, Ross G. Douglas
wiley   +1 more source

Acute Plasmodium yoelii 17XNL Infection During BCG Vaccination Limits T Cell Responses and Mycobacterial Growth Inhibition

Immunology, Volume 176, Issue 3, Page 373-384, November 2025.
Tuberculosis and malaria overlap in many sub‐Saharan African countries where BCG vaccination is routinely administered. The aim of this study was to determine whether the timing of BCG vaccination in relation to a malaria infection has implications for BCG vaccine efficacy.
Emily Tangie, Nawamin Pinpathomrat, Rachel Tanner, Nai‐Jen Hsu, Alexandra J. Spencer, Muazzam Jacobs, Helen Mcshane, Roanne Keeton   +7 more
wiley   +1 more source

Oligochitosan Conjugates of the Antimalarials Dihydroartemisinin and Lumefantrine: Synthesis, Stability, Cell Viability, and Antiplasmodial Studies

Applied Research, Volume 4, Issue 5, October 2025.
Schematic representation of orally administered antimalarial–oligochitosan conjugates. The mucoadhesive properties of oligochitosan facilitate enhanced drug absorption across the intestinal epithelium (Image created in BioRender.com & Microsoft 365 PowerPoint).
William Matshe, Sindisiwe Mvango, Rudzani Malabi, Asongwe Tantoh, Charlene Andraos, Ibukun Famuyide, Lyndy McGaw, Sooraj Baijnath, Lynne Pilcher, Mohammed Balogun   +9 more
wiley   +1 more source

Antiplasmodial Effect of Anthocleista vogelii on Albino Mice Experimentally Infected with Plasmodium berghei berghei (NK 65)

Journal of Parasitology Research, 2014
The objective of the present study was to investigate the antiplasmodial effect of the ethanolic stem bark extract of Anthocleista vogelii at different doses in albino mice infected with Plasmodium berghei berghei (NK 65).
Lebari Barine Gboeloh, Okpok Eta Okon, Samuel Effiong Udoh   +2 more
doaj   +1 more source

Extracellular ATP triggers proteolysis and cytosolic Ca²⁺ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites

Malaria Journal, 2012
Background Plasmodium has a complex cell biology and it is essential to dissect the cell-signalling pathways underlying its survival within the host. Methods Using the fluorescence resonance energy transfer (FRET) peptide substrate Abz-AIKFFARQ-EDDnp and
Cruz Laura, Juliano Maria, Budu Alexandre, Juliano Luiz, Holder Anthony A, Blackman Michael J, Garcia Célia RS   +6 more
doaj   +1 more source

In vivo antiplasmodial evaluation of methanol mesocarp extract of Citrillus lanatus in Plasmodium berghei berghei infected mice

, 2021
Ettebong Eo, Inyang GB, Augustine Bassey, Udobang JA, Thomas PS, Essien EG, Ubulom Pe, Obot DN   +7 more
openalex   +1 more source

In Vitro and In Vivo Antimalarial Activity of LZ1, a Peptide Derived from Snake Cathelicidin

Toxins, 2019
Antimalarial drug resistance is an enormous global threat. Recently, antimicrobial peptides (AMPs) are emerging as a new source of antimalarials. In this study, an AMP LZ1 derived from snake cathelicidin was identified with antimalarial activity.
Yaqun Fang, Xiaoqin He, Pengcheng Zhang, Chuanbin Shen, James Mwangi, Cheng Xu, Guoxiang Mo, Ren Lai, Zhiye Zhang   +8 more
doaj   +1 more source

IL35 modulation altered survival, cytokine environment and histopathological consequences during malaria infection in mice

Malaria Journal, 2019
Background The immune modulating potential of IL-35 in multiple human disorders has been reported. Consequent upon the recognition of inflammatory cytokine activation and its preponderance for mediating pathology during malaria infection, the study aimed
Ramatu Omenesa Bello, Maizaton Atmadini Abdullah, Roslaini Abd Majid, Voon Kin Chin, Mohammed Faruq Abd Rachman Isnadi, Zaid Osama Ibraheem, Mohd Khairi Hussain, Mohammed Garba Magaji, Rusliza Basir   +8 more
doaj   +1 more source

Antiplasmodial effect and sub-acute toxicity of alkaloid, flavonoid and phenolic extracts of Sida acuta leaf on Plasmodium berghei -infected animals [PDF]

, 2020
Daniel P. Bliss, Sherifat Funmilola Adefolalu, Ali A. Jigam, Bashir Lawal   +3 more
openalex   +1 more source