Results 71 to 80 of about 32,923 (246)

HaloPROTAC3 does not trigger the degradation of the halotagged parasitophorous vacuole membrane protein UIS4 during Plasmodium liver stage development

Scientific Reports
Targeted protein degradation (TPD) is a novel strategy for developing therapeutics against pathogens. Prior to causing malaria, Plasmodium parasites replicate within hepatocytes as liver stages, surrounded by a parasitophorous vacuole membrane (PVM).
Melanie Lam, Alexandra Probst, Laura Torres, Ashley A. Lantigua, Matthew E. Fishbaugher, Jyothsna R. Kumar, Manuel Saldivia, Allison Torres, Shreeya Hegde, Maya Aleshnick, Charlie Jennison, Sarah G. H. Roberson, Chester J. Joyner, Ashley M. Vaughan, Brandon K. Wilder, Carole Manneville, Erika L. Flannery, David Marcellin, Beat Nyfeler, Zacharias Thiel, Sebastian A. Mikolajczak, Anke Harupa, Gabriel Mitchell   +22 more
doaj   +1 more source

Traction force generation in Plasmodium sporozoites is modulated by a surface adhesin

Journal of Microscopy, EarlyView.
Abstract Plasmodium sporozoites are the highly polarised and motile forms of the malaria parasite transmitted by mosquitoes to the vertebrate hosts. Sporozoites use myosin motors to generate retrograde flow of actin filaments. These are linked to plasma membrane spanning adhesins, which in turn bind to the extracellular environment, resulting in ...
Johanna Ripp, Dimitri Probst, Mirko Singer, Ulrich S. Schwarz, Friedrich Frischknecht   +4 more
wiley   +1 more source

MOLECULAR ANALYSIS OF PBMSP-1 GENE IN ERYTHROCYTE OF MICE INFECTED WITH Plasmodium berghei

Jurnal Kedokteran Hewan, 2018
This study aimed to analyze MSP-1 gene in mice erythrocyte infected with Plasmodium berghei using polymerase chain reaction (PCR). The result showed the existence of 462 bp DNA band which was assumed to encode MSP-1 protein with molecular weight of 19 ...
Rosnizar Rosnizar, Kartini Eriani
doaj   +1 more source

Theoretical implications of a pre-erythrocytic Plasmodium vivax vaccine for preventing relapses [PDF]

, 2017
Preventing malaria infection through vaccination requires preventing every sporozoite inoculated by mosquito bite: a major challenge for Plasmodium falciparum.
Amino, R, Mueller, I, White, MT
core   +2 more sources

The Comprehensive Roadmap Toward Malaria Elimination Using Graphene and its Promising 2D Analogs

Advanced NanoBiomed Research, Volume 5, Issue 8, August 2025.
Material based on a diversity of graphene with chemical properties of strong strength, high mobility, high transparency, good heat conductivity, biocompatibility, and chemical stability, advanced devices demonstrating antimalarial characteristics can be used for malaria treatment at different stages of malaria development from the injection of ...
Fangzhou He, George Junior, Rajashree Konar, Yuanding Huang, Ke Zhang, Lijing Ke, Meng Niu, Boon Tong Goh, Amine El Moutaouakil, Gilbert Daniel Nessim, Mohamed Belmoubarik, Weng Kung Peng   +11 more
wiley   +1 more source

Exploration of Fluorinated Peptoid‐Based Histone Deacetylase Inhibitors as Dual‐Stage Antiplasmodial Agents

Archiv der Pharmazie, Volume 358, Issue 8, August 2025.
The antiplasmodial properties of a series of fluorinated peptoid‐based histone deacetylase (HDAC) inhibitors were evaluated by screening them for their activity against asexual blood and liver stage malaria parasites and assessing their mammalian cell toxicity, to elucidate structure–activity and structure‐toxicity relationships. Compound 1h emerged as
Nina Reßing, Daniel Stopper, Thomas Martin Schäfer, Lais Pessanha de Carvalho, Elizabeth A. Winzeler, Jana Held, Finn K. Hansen   +6 more
wiley   +1 more source

Erythroferrone contributes to hepcidin repression in a mouse model of malarial anemia

Haematologica, 2017
Malaria, a major global health challenge worldwide, is accompanied by a severe anemia secondary to hemolysis and increased erythrophagocytosis. Iron is an essential functional component of erythrocyte hemoglobin and its availability is controlled by the ...
Chloé Latour, Myriam F. Wlodarczyk, Grace Jung, Aurélie Gineste, Nicolas Blanchard, Tomas Ganz, Marie-Paule Roth, Hélène Coppin, Léon Kautz   +8 more
doaj   +1 more source

A conserved protein of Babesia microti elicits partial protection against Babesia and Plasmodium infection

Parasites & Vectors, 2023
Background The protozoan parasite Babesia microti that causes the zoonotic disease babesiosis resides in the erythrocytes of its mammalian host during its life-cycle.
Yao Wang, Qianqian Zhang, Wanruo Zhang, Junhu Chen, Jianfeng Dai, Xia Zhou   +5 more
doaj   +1 more source

Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites [PDF]

, 2015
Human malaria parasites proliferate in different erythroid cell types during infection. Whilst Plasmodium vivax exhibits a strong preference for immature reticulocytes, the more pathogenic P. falciparum primarily infects mature erythrocytes.
Barrett, Michael P., Creek, Darren J., De Souza, David, Evans, Krystal J., McConville, Malcolm J., Muller, Sylke, Schofield, Louis, Srivastava, Anubhav, Waters, Andrew P.   +8 more
core   +1 more source

Fluctuating Warm and Humid Conditions Differentially Impact Immunity and Development in the Malaria Vector Anopheles stephensi

Global Change Biology, Volume 31, Issue 8, August 2025.
This study shows that fluctuating warm and humid conditions impact immune defenses, accelerate development, enhance post‐infection survival, and alter gene expression in mosquitoes, with potentially significant implications for their ability to vector malaria.
Thais Lemos‐Silva, Emma De Neef, Yarno Valgaerts, Maria L. Simões   +3 more
wiley   +1 more source