Results 71 to 80 of about 107,407 (254)

MOLECULAR ANALYSIS OF PBMSP-1 GENE IN ERYTHROCYTE OF MICE INFECTED WITH Plasmodium berghei

Jurnal Kedokteran Hewan, 2018
This study aimed to analyze MSP-1 gene in mice erythrocyte infected with Plasmodium berghei using polymerase chain reaction (PCR). The result showed the existence of 462 bp DNA band which was assumed to encode MSP-1 protein with molecular weight of 19 ...
Rosnizar Rosnizar, Kartini Eriani
doaj   +1 more source

Implications of Glutathione Levels in the Plasmodium berghei Response to Chloroquine and Artemisinin

PLoS ONE, 2015
Malaria is one of the most devastating parasitic diseases worldwide. Plasmodium drug resistance remains a major challenge to malaria control and has led to the re-emergence of the disease. Chloroquine (CQ) and artemisinin (ART) are thought to exert their
J. Vega-Rodríguez, Rebecca Pastrana-Mena, Keila Crespo-Llado, J. Ortiz, I. Ferrer-Rodríguez, A. Serrano   +5 more
semanticscholar   +1 more source

Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert, Lucie Paloque, Jean‐Michel Augereau, Flore Nardella, Michel Nguyen, Bernard Meunier, Françoise Benoit‐Vical   +6 more
wiley   +1 more source

In vivo antimalarial activity of the crude leaf extract and solvent fractions of Croton macrostachyus Hocsht. (Euphorbiaceae) against Plasmodium berghei in mice

BMC Complementary and Alternative Medicine, 2014
BackgroundThe issue of resistance in malarial infection makes development of novel drugs a necessity. An alternative source for discovering such drugs is natural products. Croton macrostachyus H. (Euphorbiaceae) is used in Ethiopian folklore medicine for
Laychiluh Bantie, Solomon Assefa, Tilahun Teklehaimanot, E. Engidawork   +3 more
semanticscholar   +1 more source

In Vitro Antiplasmodial Activity and Chemical Composition of Combretum aculeatum, a Medicinal Plant From Niger

Chemistry &Biodiversity, Volume 22, Issue 6, June 2025.
Workflow of current study. ABSTRACT Malaria remains a significant public health challenge in Niger, accounting for 5.6% of global malaria‐related deaths. Local medicinal plants are frequently used as traditional treatments for malaria, although their efficacy and safety are often insufficiently investigated.
Souleymane Magagi Damé, Louis Leclercq, Catherine Vonthron‐Sénécheau, Amadou Tidjani Ilagouma, Sergio Ortiz   +4 more
wiley   +1 more source

Erythroferrone contributes to hepcidin repression in a mouse model of malarial anemia

Haematologica, 2017
Malaria, a major global health challenge worldwide, is accompanied by a severe anemia secondary to hemolysis and increased erythrophagocytosis. Iron is an essential functional component of erythrocyte hemoglobin and its availability is controlled by the ...
Chloé Latour, Myriam F. Wlodarczyk, Grace Jung, Aurélie Gineste, Nicolas Blanchard, Tomas Ganz, Marie-Paule Roth, Hélène Coppin, Léon Kautz   +8 more
doaj   +1 more source

CXCL10highTNFαhighKi67+ Microglia Recruit and Activate CD8+ T Cells in the Brainstem During Experimental Cerebral Malaria

CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.
Microglia exhibit distinct transcriptional and morphological heterogeneity in experimental cerebral malaria (ECM) compared to physiological microglia. A unique subtype of ECM‐associated microglia, characterized by CXCL10highTNFαhighKi67+, mediates the recruitment and sustained activation of CD8+ T cells through ongoing interactions, exacerbating ...
Yi Wang, Jiao Liang, Chao Yang, Jun Wang, Qinghao Zhu, Guodong Tong, Tong Li, Ganze Li, Yuxiao Huang, Yimin Yang, Jie Ren, Yinghui Li, Yan Shen, Ya Zhao   +13 more
wiley   +1 more source

Calcium dynamics of Plasmodium berghei sporozoite motility

Cellular Microbiology, 2014
Calcium is a key signalling molecule in apicomplexan parasites and plays an important role in diverse processes including gliding motility. Gliding is essential for the malaria parasite to migrate from the skin to the liver as well as to invade host ...
Allison F. Carey, Mirko Singer, D. Bargieri, S. Thiberge, F. Frischknecht, R. Ménard, R. Amino   +6 more
semanticscholar   +1 more source

Structure–activity analysis of imino‐pyrimidinone‐fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors

The FEBS Journal, Volume 292, Issue 11, Page 2843-2864, June 2025.
Compounds were identified that inhibit the aspartic protease plasmepsin V from Plasmodium vivax. Further development of these compounds identified compounds, such as S‐WM48, that could inhibit both plasmepsin V and plasmepsin X but plasmepsin IX was not significantly inhibited.
Anthony N. Hodder, Brad E. Sleebs, Greg Adams, Sina Rezazadeh, Anna Ngo, Kate Jarman, Stephen Scally, Peter Czabotar, Hongwu Wang, John A. McCauley, David B. Olsen, Alan F. Cowman   +11 more
wiley   +1 more source

Apolipophorin-III mediates antiplasmodial epithelial responses in Anopheles gambiae (G3) mosquitoes. [PDF]

PLoS ONE, 2010
Apolipophorin-III (ApoLp-III) is known to play an important role in lipid transport and innate immunity in lepidopteran insects. However, there is no evidence of involvement of ApoLp-IIIs in the immune responses of dipteran insects such as Drosophila and
Lalita Gupta, Ju Young Noh, Yong Hun Jo, Seung Han Oh, Sanjeev Kumar, Mi Young Noh, Yong Seok Lee, Sung-Jae Cha, Sook Jae Seo, Iksoo Kim, Yeon Soo Han, Carolina Barillas-Mury   +11 more
doaj   +1 more source