Results 81 to 90 of about 32,923 (246)

Two avian Plasmodium species trigger different transcriptional responses on their vector Culex pipiens

Molecular Ecology, Volume 34, Issue 15, August 2025.
Abstract Malaria is a mosquito‐borne disease caused by protozoans of the genus Plasmodium that affects both humans and wildlife. The fitness consequences of infections by avian malaria are well known in birds, however, little information exists on its impact on mosquitoes.
Marta Garrigós, Guillem Ylla, Josué Martínez‐de la Puente, Jordi Figuerola, María José Ruiz‐López   +4 more
wiley   +1 more source

Apolipophorin-III mediates antiplasmodial epithelial responses in Anopheles gambiae (G3) mosquitoes. [PDF]

PLoS ONE, 2010
Apolipophorin-III (ApoLp-III) is known to play an important role in lipid transport and innate immunity in lepidopteran insects. However, there is no evidence of involvement of ApoLp-IIIs in the immune responses of dipteran insects such as Drosophila and
Lalita Gupta, Ju Young Noh, Yong Hun Jo, Seung Han Oh, Sanjeev Kumar, Mi Young Noh, Yong Seok Lee, Sung-Jae Cha, Sook Jae Seo, Iksoo Kim, Yeon Soo Han, Carolina Barillas-Mury   +11 more
doaj   +1 more source

The multifunctional autophagy pathway in the human malaria parasite, Plasmodium falciparum. [PDF]

, 2013
Autophagy is a catabolic pathway typically induced by nutrient starvation to recycle amino acids, but can also function in removing damaged organelles. In addition, this pathway plays a key role in eukaryotic development. To date, not much is known about
Bunnik, Evelien M, Cervantes, Serena, Conner, Christopher M, Escalante, Aster, Florens, Laurence, Le Roch, Karine G, Ponts, Nadia, Prudhomme, Jacques, Saraf, Anita, Sardiu, Mihaela E   +9 more
core   +4 more sources

Cyclical Transmission of Plasmodium berghei in the Laboratory [PDF]

Nature, 1952
CYCLICAL transmission of P. berghei has been successfully carried out under experimental conditions. A batch of laboratory-bred A. quadrimaculatus and A. stephensi fed on February 15 on a hamster infected eight days previously with the Kasapa strain of P. berghei.
W. J. Wall, M. Yoeli
openaire   +3 more sources

Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert, Lucie Paloque, Jean‐Michel Augereau, Flore Nardella, Michel Nguyen, Bernard Meunier, Françoise Benoit‐Vical   +6 more
wiley   +1 more source

Methanol Extract of Ficus trigonata Stem Bark Demonstrated Antiplasmodial Activity in Mice

Baghdad Journal of Biochemistry and Applied Biological Sciences
Malaria, caused by Plasmodium parasites, remains a global health concern, with drug resistance complicating control efforts. Plant-derived compounds have emerged as potential antimalarial agents.
Suleiman mahmoud Jada, Yusuf Umar, Abdullahi Usman Wurochekke   +2 more
doaj   +1 more source

Contribution of the Ly49E natural killer receptor in the immune response to Plasmodium berghei infection and control of hepatic parasite development. [PDF]

PLoS ONE, 2014
Natural killer (NK) cells have different roles in the host response against Plasmodium-induced malaria depending on the stage of infection. Liver NK cells have a protective role during the initial hepatic stage of infection by production of the TH1-type ...
Jessica Filtjens, Lander Foquet, Sylvie Taveirne, Els Van Ammel, Mandy Vanhees, Aline Van Acker, Tessa Kerre, Tom Taghon, Bart Vandekerckhove, Jean Plum, Philippe E Van den Steen, Georges Leclercq   +11 more
doaj   +1 more source

In Vitro Antiplasmodial Activity and Chemical Composition of Combretum aculeatum, a Medicinal Plant From Niger

Chemistry &Biodiversity, Volume 22, Issue 6, June 2025.
Workflow of current study. ABSTRACT Malaria remains a significant public health challenge in Niger, accounting for 5.6% of global malaria‐related deaths. Local medicinal plants are frequently used as traditional treatments for malaria, although their efficacy and safety are often insufficiently investigated.
Souleymane Magagi Damé, Louis Leclercq, Catherine Vonthron‐Sénécheau, Amadou Tidjani Ilagouma, Sergio Ortiz   +4 more
wiley   +1 more source

CXCL10highTNFαhighKi67+ Microglia Recruit and Activate CD8+ T Cells in the Brainstem During Experimental Cerebral Malaria

CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.
Microglia exhibit distinct transcriptional and morphological heterogeneity in experimental cerebral malaria (ECM) compared to physiological microglia. A unique subtype of ECM‐associated microglia, characterized by CXCL10highTNFαhighKi67+, mediates the recruitment and sustained activation of CD8+ T cells through ongoing interactions, exacerbating ...
Yi Wang, Jiao Liang, Chao Yang, Jun Wang, Qinghao Zhu, Guodong Tong, Tong Li, Ganze Li, Yuxiao Huang, Yimin Yang, Jie Ren, Yinghui Li, Yan Shen, Ya Zhao   +13 more
wiley   +1 more source

Structure–activity analysis of imino‐pyrimidinone‐fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors

The FEBS Journal, Volume 292, Issue 11, Page 2843-2864, June 2025.
Compounds were identified that inhibit the aspartic protease plasmepsin V from Plasmodium vivax. Further development of these compounds identified compounds, such as S‐WM48, that could inhibit both plasmepsin V and plasmepsin X but plasmepsin IX was not significantly inhibited.
Anthony N. Hodder, Brad E. Sleebs, Greg Adams, Sina Rezazadeh, Anna Ngo, Kate Jarman, Stephen Scally, Peter Czabotar, Hongwu Wang, John A. McCauley, David B. Olsen, Alan F. Cowman   +11 more
wiley   +1 more source