Background Malaria can be caused by five Plasmodium species. Due to their higher prevalence, much of the research concentrates on Plasmodium falciparum and Plasmodium vivax. In Burkina Faso, where P.
Gnémé Awa+7 more
doaj +1 more source
Submicroscopic placental infection by non-falciparum Plasmodium spp. [PDF]
Among the Plasmodium species that infect humans, adverse effects of P. falciparum and P. vivax have been extensively studied and reported with respect to poor outcomes particularly in first time mothers and in pregnant women living in areas with unstable
Justin Y A Doritchamou+6 more
doaj +1 more source
Prospective evaluation of artemether-lumefantrine for the treatment of non-falciparum and mixed-species malaria in Gabon [PDF]
Background: The recommendation of artemisinin combination therapy (ACT) as first-line treatment for uncomplicated falciparum malaria is supported by a plethora of high quality clinical trials.
Adegnika, Ayola A.+12 more
core +1 more source
Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites
Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert+6 more
wiley +1 more source
Ned-19 inhibition of parasite growth and multiplication suggests a role for NAADP mediated signalling in the asexual development of plasmodium falciparum [PDF]
BACKGROUND: Although malaria is a preventable and curable human disease, millions of people risk to be infected by the Plasmodium parasites and to develop this illness. Therefore, there is an urgent need to identify new anti-malarial drugs.
Alano, Pietro+5 more
core +2 more sources
Sustainable Synthesis of 1,2,3‐Triazoles using Cyrene as a Biodegradable Solvent in Click Chemistry
Green triazoles: The first successful synthesis of 1,2,3‐triazoles using Cyrene as a biodegradable and non‐toxic solvent in click chemistry has been developed. This sustainable approach allows product isolation by simple precipitation in water, eliminating the need for organic solvent extractions and chromatographic purifications, thus minimizing waste
Andrea Citarella+4 more
wiley +1 more source
Identification of 11 potential malaria vaccine candidates using Bioinformatics [PDF]
In this paper, we suggested eleven protein targets to be used as possible vaccines against Plasmodium falciparum causative agent of almost two to three million deaths per year. A comprehensive analysis of protein target have been selected from the small experimental fragment of antigen in the P.
arxiv
Activation of human NK cells by Plasmodium-infected red blood cells.
This chapter describes a protocol to assess activation of human NK cells following in vitro stimulation with malaria-infected red blood cells. Activation is assessed by flow cytometry, staining for cell surface expression of CD69 and accumulation of ...
Horowitz, Amir, Riley, Eleanor M
core +1 more source
Benzochalcogenodiazoles, synthesis and applications in medicinal chemistry and photomedicine.
Benzochalcogenodiazoles BXDs (BOD: benzoxadiazole, BTD: benzothiadiazole, or BSD: benzoselenadiazole) are aromatic bicyclic compounds, containing chalcogen atoms, with applications ranging from material to medicinal chemistry. The recent developments in their preparation and functionalization are taking advantage of new methodologies such as C‐H ...
Jean-Elie Zheng+2 more
wiley +1 more source
Objective: To test the sensitivity of locally available strips for the detection of Plasmodium Vivax and Plasmodium Falciparum species at a tertiary care hospital. Study Design: Cross-sectional study.
Nabila Rafique+5 more
doaj +1 more source