Results 81 to 90 of about 192,328 (309)

In Vitro Antiplasmodial Activity and Chemical Composition of Combretum aculeatum, a Medicinal Plant From Niger

Chemistry &Biodiversity, EarlyView.
Workflow of current study. ABSTRACT Malaria remains a significant public health challenge in Niger, accounting for 5.6% of global malaria‐related deaths. Local medicinal plants are frequently used as traditional treatments for malaria, although their efficacy and safety are often insufficiently investigated.
Souleymane Magagi Damé, Louis Leclercq, Catherine Vonthron‐Sénécheau, Amadou Tidjani Ilagouma, Sergio Ortiz   +4 more
wiley   +1 more source

A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection [PDF]

, 2017
Falciparum malaria is a major parasitic disease causing widespread morbidity and mortality globally. Artemisinin derivatives---the most effective and widely-used antimalarials that have helped reduce the burden of malaria by 60% in some areas over the past decade---have recently been found to induce growth retardation of blood-stage Plasmodium ...
arxiv   +1 more source

The prevalence of Plasmodium falciparum in sub Saharan Africa since 1900

Nature, 2017
Malaria transmission is influenced by climate, land use and deliberate interventions. Recent declines have been observed in malaria transmission. Here we show that the African continent has witnessed a long-term decline in the prevalence of Plasmodium ...
R. Snow, B. Sartorius, D. Kyalo, Joseph Maina, P. Amratia, Clara W. Mundia, P. Bejon, A. Noor   +7 more
semanticscholar   +1 more source

Incidence of malarial infection and response to antimalarial drugs at Districts Lower Dir and Swat of Khyber Pakhtunkhwa, Pakistan

Dialogues in Health, 2022
Malaria is the leading cause of mortality and morbidity all over the world. Several antimalarial drugs are available for the treatment of malaria. The main objective of this study was to investigate the incidence of malarial infection and the use of ...
Nasib Zaman, Faiz Ul Haq, Zafran Khan, Wajahat Uallah, Daniya Ualiyeva, Yasir Waheed, Muhammad Rizwan, Raja Tahir Mahmood, Majid Mahmood   +8 more
doaj  

Performance of rapid diagnostic tests for imported malaria in clinical practice: results of a national multicenter study. [PDF]

PLoS ONE, 2013
We compared the performance of four rapid diagnostic tests (RDTs) for imported malaria, and particularly Plasmodium falciparum infection, using thick and thin blood smears as the gold standard.
Sandrine Houzé, Isabelle Boutron, Anne Marmorat, Marie Dalichampt, Christophe Choquet, Isabelle Poilane, Nadine Godineau, Anne-Sophie Le Guern, Marc Thellier, Hélène Broutier, Odile Fenneteau, Pascal Millet, Stéphanie Dulucq, Véronique Hubert, Pascal Houzé, Florence Tubach, Jacques Le Bras, Sophie Matheron   +17 more
doaj   +1 more source

Microvascular sequestration of Plasmodium falciparum

Blood, 2011
A 2-year-old boy presented to a clinic in rural Mali with fever and malaise. Thick and thin blood films stained with Giemsa (left and right, respectively) revealed that 25.7% of circulating erythrocytes were parasitized with Plasmodium falciparum (273 450 ring-stage parasites per microliter of whole blood). The child had an axillary temperature of 36.9°
Jeannette T Beaudry, Rick M. Fairhurst
openaire   +4 more sources

Profiling Serine Hydrolases in the Leishmania Host‐Pathogen Interactome Using Cell‐Permeable Activity‐Based Fluorophosphonate Probes

ChemBioChem, Accepted Article.
Leishmaniasis, a vector borne neglected tropical disease, caused by the protozoan parasite Leishmania, is a major global public health challenge with millions of new cases annually. Treatment of leishmaniasis is difficult for many reasons including a multiple life‐cycle stages, involving both an infective insect vector form, the promastigote, and a ...
Jaime A. Isern, Exequiel O.J. Porta, Karunakaran Kalesh, Zisis Koutsogiannis, Davide Cazzola, Ehmke Pohl, Paul Denny, Patrick G. Steel   +7 more
wiley   +1 more source

False-negative malaria rapid diagnostic tests in Rwanda: impact of Plasmodium falciparum isolates lacking hrp2 and declining malaria transmission

Malaria Journal, 2017
Rapid diagnostic tests (RDTs) for histidine rich protein 2 (HRP2) are often used to determine whether persons with fever should be treated with anti-malarials. However, Plasmodium falciparum parasites with a deletion of the hrp2 gene yield false-negative
C. Kozycki, Noella Umulisa, S. Rulisa, E. I. Mwikarago, J. Musabyimana, J. Habimana, C. Karema, D. Krogstad   +7 more
semanticscholar   +1 more source

Chemical Protein Engineering: Backbone Cyclization Rescues Folding of a 183‐Residue Truncated Domain of Malaria Parasite Protein PfAMA1

Chemistry – A European Journal, EarlyView.
We report the first chemical synthesis of a 183‐residue functional truncated cyclic PfAMA1 domain I protein using multi‐segment native chemical ligation and head‐to‐tail cyclization to introduce conformational constraints, thereby facilitating protein folding and providing novel strategies for miniature protein engineering.
Jamsad Mannuthodikayil, Vishal Malik, Abhisek Kar, Sameer Singh, Kalyaneswar Mandal   +4 more
wiley   +1 more source

Submicroscopic placental infection by non-falciparum Plasmodium spp. [PDF]

PLoS Neglected Tropical Diseases, 2018
Among the Plasmodium species that infect humans, adverse effects of P. falciparum and P. vivax have been extensively studied and reported with respect to poor outcomes particularly in first time mothers and in pregnant women living in areas with unstable
Justin Y A Doritchamou, Richard A Akuffo, Azizath Moussiliou, Adrian J F Luty, Achille Massougbodji, Philippe Deloron, Nicaise G Tuikue Ndam   +6 more
doaj   +1 more source