Analysis of pir gene expression across the Plasmodium life cycle [PDF]
Malaria Journal, 2021 Background Plasmodium interspersed repeat (pir) is the largest multigene family in the genomes of most Plasmodium species. A variety of functions for the PIR proteins which they encode have been proposed, including antigenic variation, immune evasion ...
Timothy S. Little +11 more
doaj +11 more sources
Small-molecule xenomycins inhibit all stages of the Plasmodium life cycle. [PDF]
Antimicrob Agents Chemother, 2015 ABSTRACT Widespread resistance to most antimalaria drugs in use has prompted the search for novel candidate compounds with activity against Plasmodium asexual blood stages to be developed for treatment.
Erath J +9 more
europepmc +7 more sources
The s48/45 six-cysteine proteins: mediators of interaction throughout the Plasmodium life cycle. [PDF]
Int J Parasitol, 2017 During their life cycle Plasmodium parasites rely upon an arsenal of proteins that establish key interactions with the host and vector, and between the parasite sexual stages, with the purpose of ensuring infection, reproduction and proliferation. Among these is a group of secreted or membrane-anchored proteins known as the six-cysteine (6-cys) family.
Arredondo SA, Kappe SHI.
europepmc +8 more sources
Targeted Deletion of a Plasmodium Site-2 Protease Impairs Life Cycle Progression in the Mammalian Host. [PDF]
PLoS ONE, 2017 Site-2 proteases (S2P) belong to the M50 family of metalloproteases, which typically perform essential roles by mediating activation of membrane-bound transcription factors through regulated intramembrane proteolysis (RIP).
Konstantinos Koussis +6 more
doaj +8 more sources
Variation in selective constraints along the Plasmodium life cycle. [PDF]
Infect Genet Evol, 2021 Plasmodium parasites, the cause of malaria, have a complex life cycle, infecting alternatively vertebrate hosts and female Anopheles mosquitoes and undergoing intra- and extra-cellular development in several organs of these hosts. Most of the ~5000 protein-coding genes present in Plasmodium genomes are only expressed at specific life stages, and ...
Tebben K, Bradwell K, Serre D.
europepmc +5 more sources
Malaria Diagnosis and the Plasmodium Life Cycle: the BFO Perspective [PDF]
Nature Precedings, 2010 Definitive diagnosis of malaria requires the demonstration through laboratory tests of the presence within the patient of malaria parasites or their components.
Werner Ceusters +2 more
semanticscholar +6 more sources
Targeting Plasmodium Life Cycle with Novel Parasite Ligands as Vaccine Antigens. [PDF]
Vaccines (Basel)The WHO reported an estimated 249 million malaria cases and 608,000 malaria deaths in 85 countries in 2022. A total of 94% of malaria deaths occurred in Africa, 80% of which were children under 5. In other words, one child dies every minute from malaria.
Khan S, Patel MP, Patni AD, Cha SJ.
europepmc +5 more sources
A proteomic view of the Plasmodium falciparum life cycle [PDF]
Nature, 2002 The completion of the Plasmodium falciparum clone 3D7 genome provides a basis on which to conduct comparative proteomics studies of this human pathogen. Here, we applied a high-throughput proteomics approach to identify new potential drug and vaccine targets and to better understand the biology of this complex protozoan parasite.
Laurence Florens +17 more
semanticscholar +5 more sources
The Malaria Cell Atlas: Single parasite transcriptomes across the complete <i>Plasmodium</i> life cycle. [PDF]
Science, 2019 Mapping the malaria parasite Several species of the parasite Plasmodium cause human malarial diseases, and, despite determined control efforts, a huge global disease burden remains. Howick et al. present a single-cell analysis of transcription across the
Howick VM +15 more
europepmc +7 more sources
Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice [PDF]
Nature Communications, 2015 Experimental studies of Plasmodium parasites that infect humans are restricted by their host specificity. Humanized mice offer a means to overcome this and further provide the opportunity to observe the parasites in vivo.
Valérie Soulard +15 more
semanticscholar +6 more sources