Results 1 to 10 of about 67,974 (216)

Evolving Gene Regulatory Networks with Mobile DNA Mechanisms

, 2013
This paper uses a recently presented abstract, tuneable Boolean regulatory network model extended to consider aspects of mobile DNA, such as transposons.
Adamatzky, Andrew, Bull, Larry
core   +1 more source

Population Pharmacokinetics and Pharmacodynamics of Artemether and Lumefantrine During Combination Treatment in Children with Uncomplicated Falciparum Malaria in Tanzania. [PDF]

, 2010
The combination of artemether (ARM) and lumefantrine is currently the first-line treatment of uncomplicated falciparum malaria in mainland Tanzania. While the exposure to lumefantrine has been associated with the probability of adequate clinical and ...
Annerberg, Anna, Ashton, Michael, Björkman, Anders, Dahlström, Sabina, Färnert, Anna, Gil, Pedro, Hietala, Sofia Friberg, Lindegårdh, Niklas, Mårtensson, Andreas, Ngasala, Billy, Premji, Zul   +10 more
core   +4 more sources

Sustainable control of Anopheles mosquito population [PDF]

, 2014
Despite the widespread use of insecticides, community engagement programmes and preventive measures mosquito borne diseases are growing and new tools to prevent the spread of disease are urgently needed. An alternative control measure for the eradication
Birch, Philip, Chatwin, Chris, Faithpraise, Fina Otosi, Obu, Joseph, Olawale, Babatunde, Young, Rupert   +5 more
core   +1 more source

Signalling in malaria parasites – The MALSIG consortium#

Parasite, 2009
Depending on their developmental stage in the life cycle, malaria parasites develop within or outside host cells, and in extremely diverse contexts such as the vertebrate liver and blood circulation, or the insect midgut and hemocoel.
Doerig C., Baker D., Billker O., Blackman M.J., Chitnis C., Kumar Dhar S., Heussler V., Holder A.A., Kocken C., Krishna S., Langsley G., Lasonder E., Menard R., Meissner M., Pradel G., Ranford-Cartwright L., Sharma A., Sharma P., Tardieux T., Tatu U., Alano P.   +20 more
doaj   +1 more source

Malaria parasites: the great escape

Frontiers in Immunology, 2016
Parasites of the genus Plasmodium have a complex life cycle. They alternate between their final mosquito host and their intermediate hosts. The parasite can be either extra- or intracellular, depending on the stage of development.
Laurent Rénia, Yun Shan Goh
doaj   +1 more source

Studies of Potency and Efficacy of an Optimized Artemisinin-Quinoline Hybrid against Multiple Stages of the Plasmodium Life Cycle. [PDF]

Pharmaceuticals (Basel), 2021
Quadros HC, Çapcı A, Herrmann L, D'Alessandro S, Fontinha D, Azevedo R, Villarreal W, Basilico N, Prudêncio M, Tsogoeva SB, Moreira DRM.   +10 more
europepmc   +1 more source

Is vaccination the only option for possible global malaria eradication? [PDF]

, 2006
In the last century, vaccines, together with the discovery of antibiotics have been powerful tools in the management of infectious diseases. Both were of particular importance in reducing the morbidity and mortality associated with infections prevailing ...
Tonna, Ivan
core  

mosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiae

Nature Communications
Plasmodium, the causative agents of malaria, are obtained by mosquitoes from an infected human. Following Plasmodium acquisition by Anopheles gambiae, mosquito gamma-interferon-inducible lysosomal thiol reductase (mosGILT) plays a critical role in its ...
Brady Dolan, Tomás Correa Gaviria, Yuemei Dong, Peter Cresswell, George Dimopoulos, Yu-Min Chuang, Erol Fikrig   +6 more
doaj   +1 more source

Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts

Nature Communications, 2017
The role of O-glycosylation in the malaria life cycle is largely unknown. Here, the authors identify a Plasmodium protein O-fucosyltransferase and show that it is important for normal trafficking of a subset of surface proteins, particularly CSP and TRAP,
Sash Lopaticki, Annie S. P. Yang, Alan John, Nichollas E. Scott, James P. Lingford, Matthew T. O’Neill, Sara M. Erickson, Nicole C. McKenzie, Charlie Jennison, Lachlan W. Whitehead, Donna N. Douglas, Norman M. Kneteman, Ethan D. Goddard-Borger, Justin A. Boddey   +13 more
doaj   +1 more source

Expanding the fluorescent toolkit: Blue fluorescent protein-expressing Plasmodium berghei for enhanced multiplex microscopy.

PLoS ONE
Fluorescent proteins are widely used as markers to differentiate genetically modified cells from their wild-type counterparts. In malaria research, the prevalent fluorescent markers include red fluorescent proteins (RFPs) and their derivatives, such as ...
Kodzo Atchou, Reto Caldelari, Magali Roques, Jacqueline Schmuckli-Maurer, Raphael Beyeler, Volker Heussler   +5 more
doaj   +1 more source