Analysis of pir gene expression across the Plasmodium life cycle [PDF]
Malaria Journal, 2021 Background Plasmodium interspersed repeat (pir) is the largest multigene family in the genomes of most Plasmodium species. A variety of functions for the PIR proteins which they encode have been proposed, including antigenic variation, immune evasion ...
Timothy S. Little +11 more
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Targeted Deletion of a Plasmodium Site-2 Protease Impairs Life Cycle Progression in the Mammalian Host. [PDF]
PLoS ONE, 2017 Site-2 proteases (S2P) belong to the M50 family of metalloproteases, which typically perform essential roles by mediating activation of membrane-bound transcription factors through regulated intramembrane proteolysis (RIP).
Konstantinos Koussis +6 more
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A Plasmodium falciparum strain expressing GFP throughout the parasite's life-cycle. [PDF]
PLoS ONE, 2010 The human malaria parasite Plasmodium falciparum is responsible for the majority of malaria-related deaths. Tools allowing the study of the basic biology of P.
Arthur M Talman +2 more
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Enlightening the malaria parasite life cycle: bioluminescent Plasmodium in fundamental and applied research [PDF]
Frontiers in Microbiology, 2015 The unicellular protozoan parasites of the genus Plasmodium impose on human health worldwide the enormous burden of malaria. The possibility to genetically modify several species of malaria parasites represented a major advance in the possibility to ...
Giulia eSiciliano, Pietro eAlano
doaj +2 more sources
The s48/45 six-cysteine proteins: mediators of interaction throughout the Plasmodium life cycle. [PDF]
Int J Parasitol, 2017 Arredondo SA, Kappe SHI.
europepmc +3 more sources
Small-molecule xenomycins inhibit all stages of the Plasmodium life cycle. [PDF]
Antimicrob Agents Chemother, 2015 Erath J +9 more
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Genetic Investigation of Tricarboxylic Acid Metabolism during the Plasmodium falciparum Life Cycle [PDF]
Cell Reports, 2015 New antimalarial drugs are urgently needed to control drug-resistant forms of the malaria parasite Plasmodium falciparum. Mitochondrial electron transport is the target of both existing and new antimalarials.
Hangjun Ke +9 more
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Same, same but different: Exploring Plasmodium cell division during liver stage development
PLoS Pathogens, 2023 Plasmodium parasites have a complex life cycle alternating between a mosquito and a vertebrate host. Following the bite of an Anopheles female mosquito, Plasmodium sporozoites are transmitted from the skin to the liver; their first place of replication ...
Magali Roques +3 more
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hERG, <i>Plasmodium</i> Life Cycle, and Cross Resistance Profiling of New Azabenzimidazole Analogues of Astemizole. [PDF]
ACS Med Chem LettMambwe D +13 more
europepmc +3 more sources
Microorganisms, 2023 Malaria, caused by Plasmodium protozoal parasites, remains a leading cause of morbidity and mortality. The Plasmodium parasite has a complex life cycle, with asexual and sexual forms in humans and Anopheles mosquitoes.
Masafumi Yoshinaga +6 more
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