Analysis of pir gene expression across the Plasmodium life cycle [PDF]
Malaria Journal, 2021 Background Plasmodium interspersed repeat (pir) is the largest multigene family in the genomes of most Plasmodium species. A variety of functions for the PIR proteins which they encode have been proposed, including antigenic variation, immune evasion ...
Timothy S. Little +11 more
doaj +11 more sources
Targeted Deletion of a Plasmodium Site-2 Protease Impairs Life Cycle Progression in the Mammalian Host. [PDF]
PLoS ONE, 2017 Site-2 proteases (S2P) belong to the M50 family of metalloproteases, which typically perform essential roles by mediating activation of membrane-bound transcription factors through regulated intramembrane proteolysis (RIP).
Konstantinos Koussis +6 more
doaj +8 more sources
Small-molecule xenomycins inhibit all stages of the Plasmodium life cycle. [PDF]
Antimicrob Agents Chemother, 2015 ABSTRACT Widespread resistance to most antimalaria drugs in use has prompted the search for novel candidate compounds with activity against Plasmodium asexual blood stages to be developed for treatment.
Erath J +9 more
europepmc +7 more sources
Targeting Plasmodium Life Cycle with Novel Parasite Ligands as Vaccine Antigens. [PDF]
Vaccines (Basel)The WHO reported an estimated 249 million malaria cases and 608,000 malaria deaths in 85 countries in 2022. A total of 94% of malaria deaths occurred in Africa, 80% of which were children under 5. In other words, one child dies every minute from malaria.
Khan S, Patel MP, Patni AD, Cha SJ.
europepmc +5 more sources
Malaria Diagnosis and the Plasmodium Life Cycle: the BFO Perspective [PDF]
Nature Precedings, 2010 Definitive diagnosis of malaria requires the demonstration through laboratory tests of the presence within the patient of malaria parasites or their components.
Werner Ceusters +2 more
semanticscholar +6 more sources
The Malaria Cell Atlas: Single parasite transcriptomes across the complete <i>Plasmodium</i> life cycle. [PDF]
Science, 2019 Mapping the malaria parasite Several species of the parasite Plasmodium cause human malarial diseases, and, despite determined control efforts, a huge global disease burden remains. Howick et al. present a single-cell analysis of transcription across the
Howick VM +15 more
europepmc +7 more sources
Variation in selective constraints along the Plasmodium life cycle. [PDF]
Infect Genet Evol, 2021 Plasmodium parasites, the cause of malaria, have a complex life cycle, infecting alternatively vertebrate hosts and female Anopheles mosquitoes and undergoing intra- and extra-cellular development in several organs of these hosts. Most of the ~5000 protein-coding genes present in Plasmodium genomes are only expressed at specific life stages, and ...
Tebben K, Bradwell K, Serre D.
europepmc +5 more sources
Disruption of the Plasmodium falciparum Life Cycle through Transcriptional Reprogramming by Inhibitors of Jumonji Demethylases [PDF]
ACS Infectious Diseases, 2020 Little is known about the role of the three Jumonji C (JmjC) enzymes in Plasmodium falciparum (Pf). Here, we show that JIB-04 and other established inhibitors of mammalian JmjC histone demethylases kill asexual blood stage parasites and are even more ...
Krista A. Matthews +11 more
semanticscholar +7 more sources
Plasmodium life cycle stage classification based quantification of malaria parasitaemia in thin blood smears [PDF]
Microscopy research and technique (Print), 2018 Visual inspection for the quantification of malaria parasitaemiain (MP) and classification of life cycle stage are hard and time taking. Even though, automated techniques for the quantification of MP and their classification are reported in the ...
Naveed Abbas +6 more
openalex +2 more sources
Benzimidazole Derivatives Are Potent against Multiple Life Cycle Stages of Plasmodium falciparum Malaria Parasites [PDF]
ACS Infectious Diseases, 2021 The continued emergence of resistance to front-line antimalarial treatments is of great concern. Therefore, new compounds that potentially have a novel target in various developmental stages of Plasmodium parasites are needed to treat patients and halt ...
Meta Leshabane +13 more
openalex +2 more sources