Analysis of pir gene expression across the Plasmodium life cycle [PDF]
Malaria Journal, 2021 Background Plasmodium interspersed repeat (pir) is the largest multigene family in the genomes of most Plasmodium species. A variety of functions for the PIR proteins which they encode have been proposed, including antigenic variation, immune evasion ...
Timothy S. Little +11 more
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Variation in selective constraints along the Plasmodium life cycle. [PDF]
Infect Genet Evol, 2021 Plasmodium parasites, the cause of malaria, have a complex life cycle, infecting alternatively vertebrate hosts and female Anopheles mosquitoes and undergoing intra- and extra-cellular development in several organs of these hosts. Most of the ~5000 protein-coding genes present in Plasmodium genomes are only expressed at specific life stages, and ...
Tebben K, Bradwell K, Serre D.
europepmc +3 more sources
Enlightening the malaria parasite life cycle: bioluminescent Plasmodium in fundamental and applied research [PDF]
Frontiers in Microbiology, 2015 The unicellular protozoan parasites of the genus Plasmodium impose on human health worldwide the enormous burden of malaria. The possibility to genetically modify several species of malaria parasites represented a major advance in the possibility to ...
Giulia eSiciliano, Pietro eAlano
doaj +5 more sources
Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features. [PDF]
PLoS Computational Biology, 2019 Empirical evidence suggests that the malaria parasite Plasmodium falciparum employs a broad range of mechanisms to regulate gene transcription throughout the organism's complex life cycle.
David F Read +4 more
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Malaria Diagnosis and the Plasmodium Life Cycle: the BFO Perspective [PDF]
Nature Precedings, 2009 Definitive diagnosis of malaria requires the demonstration through laboratory tests of the presence within the patient of malaria parasites or their components.
Barry Smith, Werner Ceusters
core +4 more sources
Small-molecule xenomycins inhibit all stages of the Plasmodium life cycle. [PDF]
Antimicrob Agents Chemother, 2015 ABSTRACT Widespread resistance to most antimalaria drugs in use has prompted the search for novel candidate compounds with activity against Plasmodium asexual blood stages to be developed for treatment.
Erath J +9 more
europepmc +4 more sources
Life cycle-dependent cytoskeletal modifications in Plasmodium falciparum infected erythrocytes. [PDF]
PLoS ONE, 2013 Plasmodium falciparum infection of human erythrocytes is known to result in the modification of the host cell cytoskeleton by parasite-coded proteins. However, such modifications and corresponding implications in malaria pathogenesis have not been fully ...
Hui Shi +7 more
doaj +4 more sources
Targeting Plasmodium Life Cycle with Novel Parasite Ligands as Vaccine Antigens. [PDF]
Vaccines (Basel)The WHO reported an estimated 249 million malaria cases and 608,000 malaria deaths in 85 countries in 2022. A total of 94% of malaria deaths occurred in Africa, 80% of which were children under 5. In other words, one child dies every minute from malaria. The RTS,S/AS01 malaria vaccine, which uses the Plasmodium falciparum circumsporozoite protein (CSP)
Khan S, Patel MP, Patni AD, Cha SJ.
europepmc +4 more sources
The Malaria Cell Atlas: Single parasite transcriptomes across the complete <i>Plasmodium</i> life cycle. [PDF]
Science, 2019 Mapping the malaria parasite Several species of the parasite Plasmodium cause human malarial diseases, and, despite determined control efforts, a huge global disease burden remains. Howick et al.
Howick VM +15 more
europepmc +6 more sources
A Plasmodium falciparum strain expressing GFP throughout the parasite's life-cycle. [PDF]
PLoS ONE, 2010 The human malaria parasite Plasmodium falciparum is responsible for the majority of malaria-related deaths. Tools allowing the study of the basic biology of P.
Arthur M Talman +2 more
doaj +6 more sources