Results 11 to 20 of about 36,588 (218)

Conserved RNA Binding Activity of Phosphatidyl Inositol 5-Phosphate 4-Kinase (PIP4K2A)

Frontiers in Molecular Biosciences, 2021
Plasmodium falciparum is a causative agent for malaria and has a complex life cycle in human and mosquito hosts. During its life cycle, the malarial parasite Plasmodium goes through different asexual and sexual stages, in humans and mosquitoes ...
Jatin Behari, Jatin Behari, Pranita Borkar, Pranita Borkar, Arya Vindu, Arya Vindu, Vishal Dandewad, Vishal Dandewad, Sindhuri Upadrasta, Sindhuri Upadrasta, Dhanasekaran Shanmugam, Dhanasekaran Shanmugam, Vasudevan Seshadri   +12 more
doaj   +1 more source

Apicortin defines the <i>Plasmodium</i> apical conoid body but is dispensable for the parasite life cycle. [PDF]

Life Sci Alliance
Zeeshan M, Mishra A, Pashley SL, Markus R, Brady D, Holder AA, Moores C, Tewari R.   +7 more
europepmc   +2 more sources

An epithelial serine protease, AgESP, is required for Plasmodium invasion in the mosquito Anopheles gambiae. [PDF]

PLoS ONE, 2012
Plasmodium parasites need to cross the midgut and salivary gland epithelia to complete their life cycle in the mosquito. However, our understanding of the molecular mechanism and the mosquito genes that participate in this process is still very limited ...
Janneth Rodrigues, Giselle A Oliveira, Michalis Kotsyfakis, Rajnikant Dixit, Alvaro Molina-Cruz, Ryan Jochim, Carolina Barillas-Mury   +6 more
doaj   +1 more source

Histone deacetylases play a major role in the transcriptional regulation of the Plasmodium falciparum life cycle. [PDF]

PLoS Pathogens, 2010
The apparent paucity of molecular factors of transcriptional control in the genomes of Plasmodium parasites raises many questions about the mechanisms of life cycle regulation in these malaria parasites. Epigenetic regulation has been suggested to play a
Balbir K Chaal, Archna P Gupta, Brigitta D Wastuwidyaningtyas, Yen-Hoon Luah, Zbynek Bozdech   +4 more
doaj   +1 more source

Protein Prenylation and Hsp40 in Thermotolerance of Plasmodium falciparum Malaria Parasites

mBio, 2021
During its complex life cycle, the malaria parasite survives dramatic environmental stresses, including large temperature shifts.
Emily S. Mathews, Andrew J. Jezewski, Audrey R. Odom John   +2 more
doaj   +1 more source

Plasmodium Reproduction, Cell Size, and Transcription: How to Cope With Increasing DNA Content?

Frontiers in Cellular and Infection Microbiology, 2021
Plasmodium, the unicellular parasite that causes malaria, evolved a highly unusual mode of reproduction. During its complex life cycle, invasive or transmissive stages alternate with proliferating stages, where a single parasite can produce tens of ...
Marta Machado, Marta Machado, Salome Steinke, Markus Ganter   +3 more
doaj   +1 more source

A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission

eLife, 2020
Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. Malaria-causing parasites have a life cycle with unique cell-division cycles, and a repertoire of divergent CDKs and cyclins ...
Aurélia C Balestra, Mohammad Zeeshan, Edward Rea, Carla Pasquarello, Lorenzo Brusini, Tobias Mourier, Amit Kumar Subudhi, Natacha Klages, Patrizia Arboit, Rajan Pandey, Declan Brady, Sue Vaughan, Anthony A Holder, Arnab Pain, David JP Ferguson, Alexandre Hainard, Rita Tewari, Mathieu Brochet   +17 more
doaj   +1 more source

Checks and balances? DNA replication and the cell cycle in Plasmodium

Parasites & Vectors, 2018
It is over 100 years since the life-cycle of the malaria parasite Plasmodium was discovered, yet its intricacies remain incompletely understood - a knowledge gap that may prove crucial for our efforts to control the disease.
Holly Matthews, Craig W. Duffy, Catherine J. Merrick   +2 more
doaj   +1 more source

Plasmodium falciparum Calcium-Dependent Protein Kinase 4 is Critical for Male Gametogenesis and Transmission to the Mosquito Vector

mBio, 2021
Gametocytes of the malaria parasite Plasmodium are taken up by the mosquito vector with an infectious blood meal, representing a critical stage for parasite transmission.
Sudhir Kumar, Meseret T. Haile, Michael R. Hoopmann, Linh T. Tran, Samantha A. Michaels, Seamus R. Morrone, Kayode K. Ojo, Laura M. Reynolds, Ulrike Kusebauch, Ashley M. Vaughan, Robert L. Moritz, Stefan H. I. Kappe, Kristian E. Swearingen   +12 more
doaj   +1 more source

Life cycle-dependent cytoskeletal modifications in Plasmodium falciparum infected erythrocytes. [PDF]

PLoS ONE, 2013
Plasmodium falciparum infection of human erythrocytes is known to result in the modification of the host cell cytoskeleton by parasite-coded proteins. However, such modifications and corresponding implications in malaria pathogenesis have not been fully ...
Hui Shi, Zhuo Liu, Ang Li, Jing Yin, Alvin G L Chong, Kevin S W Tan, Yong Zhang, Chwee Teck Lim   +7 more
doaj   +1 more source