Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice [PDF]
Nature Communications, 2015 Experimental studies of Plasmodium parasites that infect humans are restricted by their host specificity. Humanized mice offer a means to overcome this and further provide the opportunity to observe the parasites in vivo.
Valérie Soulard +15 more
semanticscholar +6 more sources
A Plasmodium falciparum strain expressing GFP throughout the parasite's life-cycle. [PDF]
PLoS ONE, 2010 The human malaria parasite Plasmodium falciparum is responsible for the majority of malaria-related deaths. Tools allowing the study of the basic biology of P.
Arthur M Talman +2 more
doaj +8 more sources
A proteomic view of the Plasmodium falciparum life cycle [PDF]
Nature, 2002 The completion of the Plasmodium falciparum clone 3D7 genome provides a basis on which to conduct comparative proteomics studies of this human pathogen. Here, we applied a high-throughput proteomics approach to identify new potential drug and vaccine targets and to better understand the biology of this complex protozoan parasite.
Laurence Florens +17 more
semanticscholar +5 more sources
The s48/45 six-cysteine proteins: mediators of interaction throughout the Plasmodium life cycle. [PDF]
Int J Parasitol, 2017 During their life cycle Plasmodium parasites rely upon an arsenal of proteins that establish key interactions with the host and vector, and between the parasite sexual stages, with the purpose of ensuring infection, reproduction and proliferation. Among these is a group of secreted or membrane-anchored proteins known as the six-cysteine (6-cys) family.
Arredondo SA, Kappe SHI.
europepmc +6 more sources
Life cycle studies of the hexose transporter ofPlasmodiumspecies and genetic validation of their essentiality [PDF]
Molecular Microbiology, 2010 A Plasmodium falciparum hexose transporter (PfHT) has previously been shown to be a facilitative glucose and fructose transporter. Its expression in Xenopus laevis oocytes and the use of a glucose analogue inhibitor permitted chemical validation of PfHT ...
Ksenija Slavić +6 more
core +9 more sources
Genetic Investigation of Tricarboxylic Acid Metabolism during the Plasmodium falciparum Life Cycle
Cell Reports, 2015 New antimalarial drugs are urgently needed to control drug-resistant forms of the malaria parasite Plasmodium falciparum. Mitochondrial electron transport is the target of both existing and new antimalarials.
Hangjun Ke +9 more
doaj +7 more sources
Enlightening the malaria parasite life cycle: bioluminescent Plasmodium in fundamental and applied research [PDF]
Frontiers in Microbiology, 2015 The unicellular protozoan parasites of the genus Plasmodium impose on human health worldwide the enormous burden of malaria. The possibility to genetically modify several species of malaria parasites represented a major advance in the possibility to ...
Giulia eSiciliano, Pietro eAlano
doaj +4 more sources
An ultrasensitive NanoLuc-based luminescence system for monitoring Plasmodium berghei throughout its life cycle [PDF]
Malaria Journal, 2016 Bioluminescence imaging is widely used for cell-based assays and animal imaging studies, both in biomedical research and drug development. Its main advantages include its high-throughput applicability, affordability, high sensitivity, operational ...
Mariana De Niz +4 more
semanticscholar +6 more sources
The Integral Plasmodium Life Cycle Phenomenon: Gametocyte Genes [PDF]
Journal of Bacteriology & Parasitology, 2015 Gametocytes are the sexual stages of the Plasmodium species. The transmission of parasite relies on these gametocytes which are the crucial link in its life cycle. The biology of parasitic life cycle is complex with the invasion of host red blood cells (RBCs) by merozoites after the pre-erythrocytic invasion and followed with erythrocytic invasions and
Vineeta Singh Amit Kumar
semanticscholar +3 more sources
Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features. [PDF]
PLoS Computational Biology, 2019 Empirical evidence suggests that the malaria parasite Plasmodium falciparum employs a broad range of mechanisms to regulate gene transcription throughout the organism's complex life cycle.
David F Read +4 more
doaj +3 more sources