Life cycle studies of the hexose transporter ofPlasmodiumspecies and genetic validation of their essentiality [PDF]
Molecular Microbiology, 2010 A Plasmodium falciparum hexose transporter (PfHT) has previously been shown to be a facilitative glucose and fructose transporter. Its expression in Xenopus laevis oocytes and the use of a glucose analogue inhibitor permitted chemical validation of PfHT as a novel drug target. Following recent re-annotations of the P.
Ksenija Slavić +6 more
core +9 more sources
The Integral Plasmodium Life Cycle Phenomenon: Gametocyte Genes [PDF]
Journal of Bacteriology & Parasitology, 2015 Gametocytes are the sexual stages of the Plasmodium species. The transmission of parasite relies on these gametocytes which are the crucial link in its life cycle.
Vineeta Singh Amit Kumar
semanticscholar +3 more sources
A Plasmodium falciparum strain expressing GFP throughout the parasite's life-cycle. [PDF]
PLoS ONE, 2010 The human malaria parasite Plasmodium falciparum is responsible for the majority of malaria-related deaths. Tools allowing the study of the basic biology of P.
Arthur M Talman +2 more
doaj +8 more sources
Disruption of the Plasmodium falciparum Life Cycle through Transcriptional Reprogramming by Inhibitors of Jumonji Demethylases [PDF]
ACS Infectious Diseases, 2020 Little is known about the role of the three Jumonji C (JmjC) enzymes in Plasmodium falciparum (Pf). Here, we show that JIB-04 and other established inhibitors of mammalian JmjC histone demethylases kill asexual blood stage parasites and are even more ...
Krista A. Matthews +11 more
semanticscholar +7 more sources
Enlightening the malaria parasite life cycle: bioluminescent Plasmodium in fundamental and applied research [PDF]
Frontiers in Microbiology, 2015 The unicellular protozoan parasites of the genus Plasmodium impose on human health worldwide the enormous burden of malaria. The possibility to genetically modify several species of malaria parasites represented a major advance in the possibility to ...
Giulia eSiciliano, Pietro eAlano
doaj +4 more sources
International Journal for Parasitology: Drugs and Drug Resistance, 2017 Drugs against malaria are losing their effectiveness because of emerging drug resistance. This underscores the need for novel therapeutic options for malaria with mechanism of actions distinct from current antimalarials. To identify novel pharmacophores against malaria we have screened compounds containing structural features of natural products that ...
Bracken F. Roberts +7 more
semanticscholar +7 more sources
Genetic Investigation of Tricarboxylic Acid Metabolism during the Plasmodium falciparum Life Cycle
Cell Reports, 2015 New antimalarial drugs are urgently needed to control drug-resistant forms of the malaria parasite Plasmodium falciparum. Mitochondrial electron transport is the target of both existing and new antimalarials.
Hangjun Ke +9 more
doaj +7 more sources
Plasmodium life cycle stage classification based quantification of malaria parasitaemia in thin blood smears [PDF]
Microscopy research and technique (Print), 2018 Visual inspection for the quantification of malaria parasitaemiain (MP) and classification of life cycle stage are hard and time taking. Even though, automated techniques for the quantification of MP and their classification are reported in the ...
Naveed Abbas +6 more
openalex +2 more sources
Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features. [PDF]
PLoS Computational Biology, 2019 Empirical evidence suggests that the malaria parasite Plasmodium falciparum employs a broad range of mechanisms to regulate gene transcription throughout the organism's complex life cycle.
David F Read +4 more
doaj +3 more sources
Life cycle-dependent cytoskeletal modifications in Plasmodium falciparum infected erythrocytes. [PDF]
PLoS ONE, 2013 Plasmodium falciparum infection of human erythrocytes is known to result in the modification of the host cell cytoskeleton by parasite-coded proteins. However, such modifications and corresponding implications in malaria pathogenesis have not been fully ...
Hui Shi +7 more
doaj +5 more sources