Results 21 to 30 of about 67,974 (216)

The s48/45 six-cysteine proteins: mediators of interaction throughout the Plasmodium life cycle. [PDF]

Int J Parasitol, 2017
During their life cycle Plasmodium parasites rely upon an arsenal of proteins that establish key interactions with the host and vector, and between the parasite sexual stages, with the purpose of ensuring infection, reproduction and proliferation. Among these is a group of secreted or membrane-anchored proteins known as the six-cysteine (6-cys) family.
Arredondo SA, Kappe SHI.
europepmc   +4 more sources

hERG, <i>Plasmodium</i> Life Cycle, and Cross Resistance Profiling of New Azabenzimidazole Analogues of Astemizole. [PDF]

ACS Med Chem Lett
Toward addressing the cardiotoxicity liability associated with the antimalarial drug astemizole (AST, hERG IC50 = 0.0042 μM) and its derivatives, we designed and synthesized analogues based on compound 1 (Pf NF54 IC50 = 0.012 μM; hERG IC50 = 0.63 μM), our previously identified 3-trifluoromethyl-1,2,4-oxadiazole AST analogue.
Mambwe D, Coertzen D, Leshabane M, Mulubwa M, Njoroge M, Gibhard L, Girling G, Wicht KJ, Lee MCS, Wittlin S, Moreira DRM, Birkholtz LM, Chibale K, Chibale K.   +13 more
europepmc   +4 more sources

Genetic Investigation of Tricarboxylic Acid Metabolism during the Plasmodium falciparum Life Cycle

Cell Reports, 2015
New antimalarial drugs are urgently needed to control drug-resistant forms of the malaria parasite Plasmodium falciparum. Mitochondrial electron transport is the target of both existing and new antimalarials.
Hangjun Ke, Ian A. Lewis, Joanne M. Morrisey, Kyle J. McLean, Suresh M. Ganesan, Heather J. Painter, Michael W. Mather, Marcelo Jacobs-Lorena, Manuel Llinás, Akhil B. Vaidya   +9 more
doaj   +5 more sources

A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting Transcriptional Regulators Controlling the Plasmodium Life Cycle. [PDF]

Cell Host Microbe, 2017
Modrzynska K, Pfander C, Chappell L, Yu L, Suarez C, Dundas K, Gomes AR, Goulding D, Rayner JC, Choudhary J, Billker O.   +10 more
europepmc   +2 more sources

Same, same but different: Exploring Plasmodium cell division during liver stage development

PLoS Pathogens, 2023
Plasmodium parasites have a complex life cycle alternating between a mosquito and a vertebrate host. Following the bite of an Anopheles female mosquito, Plasmodium sporozoites are transmitted from the skin to the liver; their first place of replication ...
Magali Roques, Annina Bindschedler, Raphael Beyeler, Volker T. Heussler   +3 more
doaj   +2 more sources

Arsinothricin Inhibits Plasmodium falciparum Proliferation in Blood and Blocks Parasite Transmission to Mosquitoes

Microorganisms, 2023
Malaria, caused by Plasmodium protozoal parasites, remains a leading cause of morbidity and mortality. The Plasmodium parasite has a complex life cycle, with asexual and sexual forms in humans and Anopheles mosquitoes.
Masafumi Yoshinaga, Guodong Niu, Kunie Yoshinaga-Sakurai, Venkadesh S. Nadar, Xiaohong Wang, Barry P. Rosen, Jun Li   +6 more
doaj   +1 more source

Conserved RNA Binding Activity of Phosphatidyl Inositol 5-Phosphate 4-Kinase (PIP4K2A)

Frontiers in Molecular Biosciences, 2021
Plasmodium falciparum is a causative agent for malaria and has a complex life cycle in human and mosquito hosts. During its life cycle, the malarial parasite Plasmodium goes through different asexual and sexual stages, in humans and mosquitoes ...
Jatin Behari, Jatin Behari, Pranita Borkar, Pranita Borkar, Arya Vindu, Arya Vindu, Vishal Dandewad, Vishal Dandewad, Sindhuri Upadrasta, Sindhuri Upadrasta, Dhanasekaran Shanmugam, Dhanasekaran Shanmugam, Vasudevan Seshadri   +12 more
doaj   +1 more source

An epithelial serine protease, AgESP, is required for Plasmodium invasion in the mosquito Anopheles gambiae. [PDF]

PLoS ONE, 2012
Plasmodium parasites need to cross the midgut and salivary gland epithelia to complete their life cycle in the mosquito. However, our understanding of the molecular mechanism and the mosquito genes that participate in this process is still very limited ...
Janneth Rodrigues, Giselle A Oliveira, Michalis Kotsyfakis, Rajnikant Dixit, Alvaro Molina-Cruz, Ryan Jochim, Carolina Barillas-Mury   +6 more
doaj   +1 more source

Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice [PDF]

Nature Communications, 2015
AbstractExperimental studies of Plasmodium parasites that infect humans are restricted by their host specificity. Humanized mice offer a means to overcome this and further provide the opportunity to observe the parasites in vivo. Here we improve on previous protocols to achieve efficient double engraftment of TK-NOG mice by human primary hepatocytes ...
Soulard, Valérie, Bosson-Vanga, Henriette, Lorthiois, Audrey, Roucher, Clémentine, Franetich, Jean-François, Zanghi, Gigliola, Bordessoulles, Mallaury, Tefit, Maurel, Thellier, Marc, Morosan, Serban, Le Naour, Gilles, Capron, Frédérique, Suemizu, Hiroshi, Snounou, Georges, Moreno-Sabater, Alicia, Mazier, Dominique   +15 more
openaire   +3 more sources

Histone deacetylases play a major role in the transcriptional regulation of the Plasmodium falciparum life cycle. [PDF]

PLoS Pathogens, 2010
The apparent paucity of molecular factors of transcriptional control in the genomes of Plasmodium parasites raises many questions about the mechanisms of life cycle regulation in these malaria parasites. Epigenetic regulation has been suggested to play a
Balbir K Chaal, Archna P Gupta, Brigitta D Wastuwidyaningtyas, Yen-Hoon Luah, Zbynek Bozdech   +4 more
doaj   +1 more source