Results 21 to 30 of about 36,588 (218)

Evolutionary modelling indicates that mosquito metabolism shapes the life-history strategies of Plasmodium parasites

Nature Communications, 2023
Within-host survival and between-host transmission are key life-history traits of single-celled malaria parasites. Understanding the evolutionary forces that shape these traits is crucial to predict malaria epidemiology, drug resistance, and virulence ...
Paola Carrillo-Bustamante, Giulia Costa, Lena Lampe, Elena A. Levashina   +3 more
doaj   +1 more source

Motile mosquito stage malaria parasites: ready for their close‐up

EMBO Molecular Medicine, 2021
Many stages of the complex Plasmodium parasite life cycle, the eukaryotic pathogen that causes malaria, are extracellular and motile. This motility is essential for life cycle progression, and two studies in this issue of EMBO Molecular Medicine (Hopp et
Ashley Vaughan
doaj   +1 more source

Functional interrogation of Plasmodium genus metabolism identifies species- and stage-specific differences in nutrient essentiality and drug targeting.

PLoS Computational Biology, 2018
Several antimalarial drugs exist, but differences between life cycle stages among malaria species pose challenges for developing more effective therapies.
Alyaa M Abdel-Haleem, Hooman Hefzi, Katsuhiko Mineta, Xin Gao, Takashi Gojobori, Bernhard O Palsson, Nathan E Lewis, Neema Jamshidi   +7 more
doaj   +1 more source

Deep Learning Methods in Predicting Gene Expression Levels for the Malaria Parasite

Frontiers in Genetics, 2021
Malaria is a mosquito-borne disease caused by single-celled blood parasites of the genus Plasmodium. The most severe cases of this disease are caused by the Plasmodium species, Falciparum. Once infected, a human host experiences symptoms of recurrent and
Tuan Tran, Banafsheh Rekabdar, Chinwe Ekenna   +2 more
doaj   +1 more source

Structural Insights Into Key Plasmodium Proteases as Therapeutic Drug Targets

Frontiers in Microbiology, 2019
Malaria, caused by protozoan of genus Plasmodium, remains one of the highest mortality infectious diseases. Malaria parasites have a complex life cycle, easily adapt to their host’s immune system and have evolved with an arsenal of unique proteases which
Manasi Mishra, Vigyasa Singh, Shailja Singh, Shailja Singh   +3 more
doaj   +1 more source

Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features.

PLoS Computational Biology, 2019
Empirical evidence suggests that the malaria parasite Plasmodium falciparum employs a broad range of mechanisms to regulate gene transcription throughout the organism's complex life cycle.
David F Read, Kate Cook, Yang Y Lu, Karine G Le Roch, William Stafford Noble   +4 more
doaj   +1 more source

MRE11 Is Crucial for Malaria Parasite Transmission and Its Absence Affects Expression of Interconnected Networks of Key Genes Essential for Life

Cells, 2020
The meiotic recombination 11 protein (MRE11) plays a key role in DNA damage response and maintenance of genome stability. However, little is known about its function during development of the malaria parasite Plasmodium.
David S. Guttery, Abhinay Ramaprasad, David J. P. Ferguson, Mohammad Zeeshan, Rajan Pandey, Declan Brady, Anthony A. Holder, Arnab Pain, Rita Tewari   +8 more
doaj   +1 more source

The role of the liver in the migration of parasites of global significance

Parasites & Vectors, 2019
Many parasites migrate through different tissues during their life-cycle, possibly with the aim to enhance their fitness. This is true for species of three parasite genera of global importance, Ascaris, Schistosoma and Plasmodium, which cause significant
Gwendoline Deslyper, Derek G. Doherty, James C. Carolan, Celia V. Holland   +3 more
doaj   +1 more source

Clathrins Are Involved in the Endocytosis of Host Cytosol in the Malaria Parasite. [PDF]

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This study characterized clathrin function in hemoglobin uptake from host red blood cells via the malaria parasite's specific endocytosis machinery, cytostome. Clathrin heavy chain, clathrin light chain, and AP‐1 γ subunit were found associated with certain proteins known to be involved in cytostome function, and they were localized at the collars of ...
Miao J, Lucky AB, Ning G, Xia X, Liang X, Siddiqui F, Min H, Wang C, Li X, Zhou ZH, Cui L.   +10 more
europepmc   +2 more sources

Targeting SUMOylation in Plasmodium as a Potential Target for Malaria Therapy

Frontiers in Cellular and Infection Microbiology, 2021
Malaria is a parasitic disease that represents a public health problem worldwide. Protozoans of the Plasmodium genus are responsible for causing malaria in humans.
Daffiny Sumam de Oliveira, Thales Kronenberger, Giuseppe Palmisano, Carsten Wrenger, Edmarcia Elisa de Souza   +4 more
doaj   +1 more source