Results 21 to 30 of about 530,210 (299)

Life cycle-dependent cytoskeletal modifications in Plasmodium falciparum infected erythrocytes. [PDF]

PLoS ONE, 2013
Plasmodium falciparum infection of human erythrocytes is known to result in the modification of the host cell cytoskeleton by parasite-coded proteins. However, such modifications and corresponding implications in malaria pathogenesis have not been fully ...
Hui Shi, Zhuo Liu, Ang Li, Jing Yin, Alvin G L Chong, Kevin S W Tan, Yong Zhang, Chwee Teck Lim   +7 more
doaj   +5 more sources

A Novel Tool for the Generation of Conditional Knockouts To Study Gene Function across the Plasmodium falciparum Life Cycle

mBio, 2019
One of the major limitations in studying P. falciparum is that so far only asexual stages are amenable to rapid conditional genetic modification.
Marta Tibúrcio, Annie Yang, Kazuhide Yahata, Pablo Suárez-Cortés, Hugo Belda, Sebastian Baumgarten, Marga van de Vegte‐Bolmer, Geert‐Jan van Gemert, Youri van Waardenburg, Elena A. Levashina, Robert W. Sauerwein, Moritz Treeck   +11 more
openalex   +2 more sources

Histone deacetylases play a major role in the transcriptional regulation of the Plasmodium falciparum life cycle. [PDF]

PLoS Pathogens, 2010
The apparent paucity of molecular factors of transcriptional control in the genomes of Plasmodium parasites raises many questions about the mechanisms of life cycle regulation in these malaria parasites. Epigenetic regulation has been suggested to play a
Balbir K Chaal, Archna P Gupta, Brigitta D Wastuwidyaningtyas, Yen-Hoon Luah, Zbynek Bozdech   +4 more
doaj   +5 more sources

A crucial role for the C‐terminal domain of exported protein 1 during the mosquito and hepatic stages of thePlasmodium bergheilife cycle [PDF]

Cellular Microbiology, 2019
Intracellular Plasmodium parasites develop inside a parasitophorous vacuole (PV), a specialised compartment enclosed by a membrane (PVM) that contains proteins of both host and parasite origin.
Kamil Wolanin, Diana Fontinha, Margarida Sanches‐Vaz, Britta Nyboer, Kirsten Heiß, Ann‐Kristin Mueller, Miguel Prudêncio   +6 more
openalex   +2 more sources

A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting Transcriptional Regulators Controlling the Plasmodium Life Cycle. [PDF]

Cell Host Microbe, 2017
Modrzynska K, Pfander C, Chappell L, Yu L, Suarez C, Dundas K, Gomes AR, Goulding D, Rayner JC, Choudhary J, Billker O.   +10 more
europepmc   +2 more sources

4-Nitro styrylquinoline is an antimalarial inhibiting multiple stages of Plasmodium falciparum asexual life cycle

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Drugs against malaria are losing their effectiveness because of emerging drug resistance. This underscores the need for novel therapeutic options for malaria with mechanism of actions distinct from current antimalarials. To identify novel pharmacophores against malaria we have screened compounds containing structural features of natural products that ...
Bracken F. Roberts, Yongsheng Zheng, Jacob Cleaveleand, Sukjun Lee, Eun‐Young Lee, Lawrence Ayong, Yu Yuan, Debopam Chakrabarti   +7 more
semanticscholar   +7 more sources

The salivary glands and saliva of Anopheles gambiae as an essential step in the Plasmodium life cycle: A global proteomic study [PDF]

Proteomics, 2007
Valérie Choumet, Annick Carmi–Leroy, Christine Laurent, Pascal Lenormand, Jean‐Claude Rousselle, Abdelkader Namane, Charles W. Roth, Paul T. Brey   +7 more
openalex   +2 more sources

Studies of Potency and Efficacy of an Optimized Artemisinin-Quinoline Hybrid against Multiple Stages of the Plasmodium Life Cycle. [PDF]

Pharmaceuticals (Basel), 2021
Quadros HC, Çapcı A, Herrmann L, D'Alessandro S, Fontinha D, Azevedo R, Villarreal W, Basilico N, Prudêncio M, Tsogoeva SB, Moreira DRM.   +10 more
europepmc   +3 more sources

Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle

bioRxiv, 2019
Malaria is transmitted through female Anopheline mosquitoes where gamete fusion and meiosis occurs, and humans where parasites proliferate asexually. We describe a powerful approach to identify the genetic determinants of parasite fitness across both ...
Xue Li, Sudhir Kumar, Marina McDew‐White, Meseret T. Haile, Ian H. Cheeseman, Scott Emrich, Katrina A. Button-Simons, François Nosten, Stefan H. I. Kappe, Michael T. Ferdig, Tim Anderson, Ashley M. Vaughan   +11 more
openalex   +3 more sources

hERG, <i>Plasmodium</i> Life Cycle, and Cross Resistance Profiling of New Azabenzimidazole Analogues of Astemizole. [PDF]

ACS Med Chem Lett
Mambwe D, Coertzen D, Leshabane M, Mulubwa M, Njoroge M, Gibhard L, Girling G, Wicht KJ, Lee MCS, Wittlin S, Moreira DRM, Birkholtz LM, Chibale K.   +12 more
europepmc   +3 more sources