Results 21 to 30 of about 515,233 (262)

Different Life Cycle Stages of Plasmodium falciparum Induce Contrasting Responses in Dendritic Cells [PDF]

Frontiers in Immunology, 2019
Dendritic cells are key linkers of innate and adaptive immunity. Efficient dendritic cell activation is central to the acquisition of immunity and the efficacy of vaccines. Understanding how dendritic cells are affected by Plasmodium falciparum blood-stage parasites will help to understand how immunity is acquired and maintained, and how vaccine ...
Xi Zen Yap, Rachel J. Lundie, Gaoqian Feng, Joanne Pooley, James G. Beeson, Meredith O’Keeffe   +5 more
openalex   +7 more sources

Benzimidazole Derivatives Are Potent against Multiple Life Cycle Stages of Plasmodium falciparum Malaria Parasites [PDF]

ACS Infectious Diseases, 2021
The continued emergence of resistance to front-line antimalarial treatments is of great concern. Therefore, new compounds that potentially have a novel target in various developmental stages of Plasmodium parasites are needed to treat patients and halt ...
Meta Leshabane, Godwin Akpeko Dziwornu, Dina Coertzen, Janette Reader, Phanankosi Moyo, Mariëtte van der Watt, Kelly Chisanga, Consolata Nsanzubuhoro, Richard Ferger, Erica Erlank, Nelius Venter, Lizette L. Koekemoer, Kelly Chibale, Lyn‐Marié Birkholtz   +13 more
openalex   +2 more sources

A Novel Tool for the Generation of Conditional Knockouts To Study Gene Function across the Plasmodium falciparum Life Cycle

mBio, 2019
One of the major limitations in studying P. falciparum is that so far only asexual stages are amenable to rapid conditional genetic modification.
Marta Tibúrcio, Annie Yang, Kazuhide Yahata, Pablo Suárez-Cortés, Hugo Belda, Sebastian Baumgarten, Marga van de Vegte‐Bolmer, Geert‐Jan van Gemert, Youri van Waardenburg, Elena A. Levashina, Robert W. Sauerwein, Moritz Treeck   +11 more
openalex   +2 more sources

A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses

Science, 2005
Plasmodium berghei and Plasmodium chabaudi are widely used model malaria species. Comparison of their genomes, integrated with proteomic and microarray data, with the genomes of Plasmodium falciparum and Plasmodium yoelii revealed a conserved core of 4500
N. Hall, M. Karras, J. Raine, J. Carlton, Taco W. A. Kooij, M. Berriman, L. Florens, C. Janssen, A. Pain, G. Christophides, K. James, Kim M Rutherford, B. Harris, D. Harris, C. Churcher, M. Quail, D. Ormond, J. Doggett, H. Trueman, J. Mendoza, Shelby L. Bidwell, M. Rajandream, D. Carucci, J. Yates, F. Kafatos, C. Janse, B. Barrell, C. Turner, A. Waters, R. Sinden   +29 more
semanticscholar   +4 more sources

Histone deacetylases play a major role in the transcriptional regulation of the Plasmodium falciparum life cycle. [PDF]

PLoS Pathogens, 2010
The apparent paucity of molecular factors of transcriptional control in the genomes of Plasmodium parasites raises many questions about the mechanisms of life cycle regulation in these malaria parasites. Epigenetic regulation has been suggested to play a
Balbir K Chaal, Archna P Gupta, Brigitta D Wastuwidyaningtyas, Yen-Hoon Luah, Zbynek Bozdech   +4 more
doaj   +5 more sources

A crucial role for the C‐terminal domain of exported protein 1 during the mosquito and hepatic stages of thePlasmodium bergheilife cycle [PDF]

Cellular Microbiology, 2019
Intracellular Plasmodium parasites develop inside a parasitophorous vacuole (PV), a specialised compartment enclosed by a membrane (PVM) that contains proteins of both host and parasite origin.
Kamil Wolanin, Diana Fontinha, Margarida Sanches‐Vaz, Britta Nyboer, Kirsten Heiß, Ann‐Kristin Mueller, Miguel Prudêncio   +6 more
openalex   +2 more sources

Protein kinase 9 is not required for completion of the Plasmodium berghei life cycle.

Microbiological Research, 2022
Protein kinases uniquely expressed in Plasmodium represent attractive drug targets. Previous studies have reported that Plasmodium falciparum Protein kinase 9 (Pk9) phosphorylates regulatory serine 106 of the ubiquitin-conjugating enzyme (Ubc13) thereby negatively regulating its activity.
S. Narwal, Bandita Nayak, Pragya Mehra, Satish Mishra   +3 more
semanticscholar   +3 more sources

The role of cGMP signalling in regulating life cycle progression of Plasmodium [PDF]

Microbes and Infection, 2012
The 3'-5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont rupture, as well as the role of the Plasmodium berghei orthologue in ookinete differentiation and ...
Christine S. Hopp, Paul W. Bowyer, David A. Baker   +2 more
openalex   +4 more sources

Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle [PDF]

Genome Research, 2004
To investigate the role of post-transcriptional controls in the regulation of protein expression for the malaria parasite, Plasmodium falciparum, we have compared mRNA transcript and protein abundance levels for seven different stages of the parasite life cycle. A moderately high positive relationship between mRNA and protein abundance was observed for
Karine G. Le Roch, Jeffrey R. Johnson, Laurence Florens, Yingyao Zhou, Andrey Santrosyan, Munira Grainger, S. Frank Yan, Kim C. Williamson, Anthony A. Holder, Daniel J. Carucci, John R. Yates, Elizabeth A. Winzeler   +11 more
openalex   +5 more sources

A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting Transcriptional Regulators Controlling the Plasmodium Life Cycle. [PDF]

Cell Host Microbe, 2017
Modrzynska K, Pfander C, Chappell L, Yu L, Suarez C, Dundas K, Gomes AR, Goulding D, Rayner JC, Choudhary J, Billker O.   +10 more
europepmc   +2 more sources