Results 31 to 40 of about 36,588 (218)

Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis

Scientific Reports, 2018
The anaphase promoting complex/cyclosome (APC/C) is a highly conserved multi-subunit E3 ubiquitin ligase that controls mitotic division in eukaryotic cells by tagging cell cycle regulators for proteolysis.
Richard J. Wall, David J. P. Ferguson, Aline Freville, Blandine Franke-Fayard, Declan Brady, Mohammad Zeeshan, Andrew R. Bottrill, Sally Wheatley, Andrew M. Fry, Chris J. Janse, Hiroyuki Yamano, Anthony A. Holder, David S. Guttery, Rita Tewari   +13 more
doaj   +1 more source

Artemisinin resistance in P. falciparum: probing the interacting partners of Kelch13 protein in parasite

Journal of Global Antimicrobial Resistance, 2023
: Objectives: Artemisinin (ART) resistance in Plasmodium is threatening the artemisinin combination therapies—the first line of defence against malaria. ART resistance has been established to be mediated by the Plasmodium Kelch13 (PfK13) protein.
Atul, Preeti Chaudhary, Swati Gupta, Rumaisha Shoaib, Rahul Pasupureddy, Bharti Goyal, Bhumika Kumar, Om Prakash Singh, Rajnikant Dixit, Shailja Singh, Mymoona Akhter, Neera Kapoor, Veena Pande, Soumyananda Chakraborti, Kapil Vashisht, Kailash C. Pandey   +15 more
doaj   +1 more source

Long-term pathogenic response to Plasmodium relictum infection in Culex pipiens mosquito. [PDF]

PLoS ONE, 2018
The transmission of Plasmodium within a vertebrate host population is strongly associated with the life history traits of its vector. Therefore the effect of malaria infection on mosquito fecundity and longevity has traditionally received a lot of ...
Romain Pigeault, Manon Villa
doaj   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Lys48 ubiquitination during the intraerythrocytic cycle of the rodent malaria parasite, Plasmodium chabaudi. [PDF]

PLoS ONE, 2017
Ubiquitination tags proteins for different functions within the cell. One of the most abundant and studied ubiquitin modification is the Lys48 polyubiquitin chain that modifies proteins for their destruction by proteasome.
Lorena González-López, Rebeca Carballar-Lejarazú, Gerardo Arrevillaga Boni, Leticia Cortés-Martínez, Febe Elena Cázares-Raga, Abel Trujillo-Ocampo, Mario H Rodríguez, Anthony A James, Fidel de la Cruz Hernández-Hernández   +8 more
doaj   +1 more source

Phenolic Profile and Bioactive Prospects of Wild Annona Species From Angola

Chemistry &Biodiversity, EarlyView.
ABSTRACT Annona species (Annonaceae family) are valued for their nutritional and medicinal importance, especially in traditional medicine. This study investigated the phenolic profiles of the Angolan Annona muricata, Annona squamosa, and Annona senegalensis leaves, stem barks, and seeds hydroethanolic, infusion, and decoction extracts, also evaluating ...
Josefa Rangel, Ângela Liberal, Tiane C. Finimundy, Tânia S. P. Pires, Pedro Cravo, Maria Conceição Silva, Gustavo Capatti Cassiano, Lillian Barros, Maria M. Romeiras, Ângela Fernandes   +9 more
wiley   +1 more source

Cellular and molecular interactions between the apicomplexan parasites Plasmodium and Theileria and their host cells

Parasite, 2008
Apicomplexan parasites of the genera Theileria and Plasmodium have complicated life cycles including infection of a vertebrate intermediate host and an arthropod definitive host.
Heussler V.T., Stanway R.R.
doaj   +1 more source

A single-cell atlas of Plasmodium falciparum transmission through the mosquito

Nature Communications, 2021
Here the authors use single-cell RNA-seq to profile the transmission stages of the human malaria parasite Plasmodium falciparum as it progresses through the Anopheles mosquito.
Eliana Real, Virginia M. Howick, Farah A. Dahalan, Kathrin Witmer, Juliana Cudini, Clare Andradi-Brown, Joshua Blight, Mira S. Davidson, Sunil Kumar Dogga, Adam J. Reid, Jake Baum, Mara K. N. Lawniczak   +11 more
doaj   +1 more source