Results 91 to 100 of about 989,526 (402)
High performance ammonium nitrate propellant [PDF]
, 1979 A high performance propellant having greatly reduced hydrogen chloride emission is presented. It is comprised of: (1) a minor amount of hydrocarbon binder (10-15%), (2) at least 85% solids including ammonium nitrate as the primary oxidizer (about 40% to ...Anderson, F. A.core +1 more sourceClass IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio +13 morewiley +1 more sourceIn vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow +10 morewiley +1 more sourceA New Phenomenon: Sub-Tg, Solid-State, Plasticity-Induced Bonding in
Polymers
, 2015 Polymer self-adhesion due to the interdiffusion of macromolecules has been an
active area of research for several decades [70, 43, 62, 42, 72, 73, 41]. Here,
we report a new phenomenon of sub-Tg, solid-state, plasticity-induced bonding;
where amorphous ...Padhye, Nikhil, Parks, David M., Slocum, Alexander H., Trout, Bernhardt L. +3 morecore +1 more sourcePotential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk +4 morewiley +1 more sourcePlastisol Foaming Process. Decomposition of the Foaming Agent, Polymer Behavior in the Corresponding Temperature Range and Resulting Foam Properties [PDF]
, 1998 The decomposition of azodicarbonamide, used as foaming agent in PVC - plasticizer (1/1) plastisols was studied by DSC. Nineteen different plasticizers, all belonging to the ester family, two being polymeric (polyadipates), were compared.Abbiendi, G, Abe, T, Abramowicz, H, Acosta, D, Adamczyk, L, Adamus, M, Amelung, C, Anselmo, F, Antonioli, P, Arneodo, M, Ayad, R, Bacon, TC, Badgett, WF, Bailey, DC, Bailey, DS, Bamberger, A, Barbagli, G, Bari, G, Barreiro, F, Bashindzhagyan, GL, Bashkirov, V, Basile, M, Bauerdick, LAT, Bednarek, B, Behrens, U, Beier, H, Bellagamba, L, Bertolin, A, Bhadra, S, Bienlein, JK, Blaikley, HE, Bohnet, I, Bokel, C, Bornheim, A, Borzemski, P, Boscherini, D, Botje, M, Breitweg, J, Briskin, G, Brock, I, Bromley, JT, Brook, NH, Brugnera, R, Bruni, A, Bruni, G, Brümmer, N, Bukowy, M, Bulmahn, J, Burow, BD, Bussey, PJ, Butterworth, I, Butterworth, JM, Bylsma, B, Caldwell, A, Campbell-Robson, S, Capua, M, Cara Romeo, G, Carlin, R, Cartiglia, N, Cases, G, Cashmore, RJ, Castellini, G, Catterall, CD, Chapin, D, Chlebana, F, Chwastowski, J, Ciborowski, J, Cifarelli, L, Cindolo, F, Cirio, R, Cloth, P, Coböken, K, Coldewey, C, Cole, JE, Contin, A, Cooper-Sarkar, AM, Corradi, M, Corriveau, F, Costa, M, Cottingham, WN, Crittenden, J, Cross, R, D'Agostini, G, Dagan, S, Dal Corso, F, Dardo, M, Dasu, S, de Pasquale, S, de Trocóniz, JF, de Wolf, E, Deffner, R, del Peso, J, Deppe, O, Derrick, M, Deshpande, A, Desler, K, Devenish, RCE, Dhawan, S, Dolgoshein, BA, Dosselli, U, Doyle, AT, Drews, G, Dulinński, Z, Durkin, LS, Eckert, M, Edmonds, JK, Eisenberg, Y, Eisenhardt, S, Engelen, J, Epperson, D, Ermolov, PF, Eskreys, A, Fagerstroem, C-P, Feld, L, Fernández, JP, Ferrero, MI, Figiel, J, Filges, D, Fleck, JI, Foster, B, Foudas, C, Fricke, U, Frisken, WR, Fusayasu, T, Galea, R, Gallo, E, García, G, Garfagnini, A, Gendner, N, Gialas, I, Gilkinson, DJ, Gilmore, J, Ginsburg, CM, Giusti, P, Gladilin, LK, Glasman, C, Golubkov, YA, Grabosch, HJ, Graciani, R, Grothe, M, Große-Knetter, J, Grzelak, G, Göttlicher, P, Haas, T, Hain, W, Hall-Wilton, R, Hamatsu, R, Hanna, DS, Harnew, N, Hart, JC, Hartmann, H, Hartmann, J, Hartner, GF, Hasell, D, Hayes, ME, Heath, GP, Heath, HF, Heinloth, K, Heinz, L, Hernández, JM, Hervás, L, Heusch, C, Hilger, E, Hirose, T, Hochman, D, Holm, U, Homma, K, Hong, SJ, Horstmann, D, Howell, G, Hughes, VW, Hung, BHY, Hung, LW, Iacobucci, G, Iannotti, L, Iga, Y, Inuzuka, M, Ishii, T, Jakob, H-P, Jeleń, K, Jing, Z, Johnson, KF, Jones, TW, Joo, KK, Kananov, S, Karshon, U, Kasemann, M, Kasprzak, M, Katz, UF, Kerger, R, Khakzad, M, Khein, LA, Kim, CL, Kim, JY, Kisielewska, D, Kitamura, S, Klanner, R, Klimek, K, Koch, W, Koffeman, E, Kooijman, P, Korotkova, NA, Korzhavina, IA, Kotanński, A, Kowalski, H, Kowalski, T, Krakauer, D, Kuze, M, Kuzmin, VA, Kçira, D, Kötz, U, Labarga, L, Labs, J, Lamberti, L, Lane, JB, Laurenti, G, Lee, JH, Lee, SB, Levi, G, Levman, GM, Levy, A, Lim, IT, Limentani, S, Lindemann, L, Ling, TY, Liu, W, Lohrmann, E, Long, KR, Loveless, RJ, Lukina, OY, Löhr, B, Löwe, M, Maccarrone, G, Macdonald, N, Magill, S, Mallik, U, Margotti, A, Marini, G, Markun, P, Martin, JF, Martínez, M, Maselli, S, Massam, T, Matsushita, T, Mattingly, MCK, Mattingly, S, Mańczak, O, McCubbin, NA, McFall, JD, Mellado, B, Meyer, A, Meyer-Larsen, A, Mikunas, D, Milewski, J, Miller, DB, Monaco, V, Monteiro, T, Morandin, M, Muchorowski, K, Murray, WN, Musgrave, B, Nagano, K, Nam, SW, Nania, R, Nath, C, Ng, JST, Nigro, A, Notz, D, Nowak, RJ, Noyes, VA, Nylander, P, Ochs, A, Oh, BY, Ohrenberg, K, Okrasiński, JR, Orr, RS, Pac, MY, Palmonari, F, Park, IH, Park, SK, Parsons, JA, Paul, E, Pavel, N, Pawlak, JM, Pawlak, R, Pelfer, P, Pellegrino, A, Pelucchi, F, Peroni, C, Pesci, A, Petrucci, MC, Pfeiffer, M, Piccioni, D, Piotrzkowski, K, Poelz, G, Polenz, S, Polini, A, Posocco, M, Prinias, A, Proskuryakov, AS, Przybycień, M, Przybycień, MB, Puga, J, Quadt, A, Rahn, JT, Raso, M, Reeder, DD, Rembser, C, Repond, J, Ricci, F, Ritz, S, Riveline, M, Roco, M, Roff, DG, Rohde, M, Roldńn, J, Romanowski, TA, Rulikowska-Zarebska, E, Ruske, O, Ruspa, M, Ryan, JJ, Sabetfakhri, A, Sacchi, R, Sadrozinski, HF-W, Salehi, H, Sampson, S, Sartorelli, G, Saunders, RL, Savin, AA, Saxon, DH, Schioppa, M, Schlenstedt, S, Schmidke, WB, Schneekloth, U, Schott, W, Schwarzer, O, Sciulli, F, Sedgbeer, JK, Seiden, A, Selonke, F, Shah, TP, Shcheglova, LM, Sideris, D, Simmons, D, Sinclair, LE, Smith, WH, Solano, A, Solomin, AN, St-Laurent, M, Staiano, A, Stairs, DG, Stamm, J, Stanco, L, Stanek, R, Stifutkin, A, Straub, PB, Strickland, E, Stroili, R, Surrow, B, Susinno, G, Suszycki, L, Sutton, MR, Suzuki, I, Talaga, RL, Tapper, RJ, Tassi, E, Terrón, J, Teuscher, RJ, Tickner, JR, Tiecke, H, Tokushuku, K, Toothacker, WS, Trefzger, T, Tsurugai, T, Tuning, N, Tymieniecka, T, Uijterwaal, H, Ullmann, R, Umemori, K, Vaiciulis, A, van Sighem, A, Verkerke, W, Voci, C, Vossebeld, J, Votano, L, Voß, T, Vreeswijk, M, Walczak, R, Walenta, AH, Walker, R, Wang, SM, Waters, DS, Waugh, R, Wedemeyer, R, Westphal, D, Whitmore, JJ, Wichmann, R, Wick, K, Wieber, H, Wiggers, L, Williams, DC, Wing, M, Wodarczyk, M, Wolf, G, Wollmer, U, Wrńblewski, AK, Wu, JT, Wölfle, S, Yamada, S, Yamashita, T, Yamauchi, K, Yamazaki, Y, Yoshida, R, Youngman, C, Zaja̧c, J, Zakrzewski, JA, Zamora Garcia, Y, Zarnecki, AF, Zawiejski, L, Zetsche, F, Zeuner, W, Zhang, H, Zhu, Q, Zichichi, A, Zotkin, SA +424 morecore +3 more sourcesExploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair +17 morewiley +1 more sourceHigh-Performance PVC Gel for Adaptive Micro-Lenses with Variable Focal Length. [PDF]
, 2017 This paper presents a bio-inspired adaptive micro-lens with electrically tunable focus made of non-ionic high-molecular-weight polyvinyl chloride (PVC) gel. The optical device mimics the design of the crystalline lens and ciliary muscle of the human eye. Bae, Jin, Choi, Dong-Soo, Jeong, Jaeu, Kim, Sang-Youn, Lee, Jong, LIN, Liwei, Nam, Byeong, Shin, Eun-Jae +7 morecore +1 more source
