Results 31 to 40 of about 1,682,982 (408)

Ayurvedic preparations of Raudra Rasa inhibit agonist‐mediated platelet activation and restrict thrombogenicity without affecting cell viability

FEBS Open Bio, 2023
Ayurveda is considered to be one of the most ancient forms of medicine still practiced. The Ayurvedic preparation Raudra Rasa and its derivatives have been widely employed against cancer since the 12th century, but the effect of these traditional ...
Susheel Nidhi Chaurasia, Vipin Singh, Mohammad Ekhlak, Manoj Kumar Dash, Namrata Joshi, Debabrata Dash   +5 more
doaj   +1 more source

The lung is a site of platelet biogenesis and a reservoir for hematopoietic progenitors

Nature, 2017
Platelets are critical for haemostasis, thrombosis, and inflammatory responses, but the events that lead to mature platelet production remain incompletely understood.
Emma Lefrançais, Guadalupe Ortiz-Muñoz, A. Caudrillier, B. Mallavia, Fengchun Liu, D. Sayah, E. Thornton, M. Headley, T. David, S. Coughlin, M. Krummel, A. Leavitt, E. Passegué, M. Looney   +13 more
semanticscholar   +1 more source

Platelet Apoptosis Can Be Triggered Bypassing the Death Receptors

Clinical and Applied Thrombosis/Hemostasis, 2019
In nucleated cells, the extrinsic pathway of the programmed cell death (apoptosis) is triggered by interaction of death ligands of the tumor necrosis factor superfamily with the death receptors on external cell surface membrane.
Valery Leytin PhD, Armen V. Gyulkhandanyan PhD, John Freedman MD   +2 more
doaj   +1 more source

Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3 [PDF]

, 2016
Gram-negative Escherichia coli cause diseases such as sepsis and hemolytic uremic syndrome in which thrombotic disorders can be found. Direct platelet–bacterium interactions might contribute to some of these conditions; however, mechanisms of human ...
Arman, Mònica, Cox, Dermot, Henderson, Ian R., Kerrigan, Steven W., Watson, Callum N., Watson, Steve P.   +5 more
core   +3 more sources

Role of platelets and platelet receptors in cancer metastasis

Journal of Hematology & Oncology, 2018
The interaction of tumor cells with platelets is a prerequisite for successful hematogenous metastatic dissemination. Upon tumor cell arrival in the blood, tumor cells immediately activate platelets to form a permissive microenvironment.
M. Schlesinger
semanticscholar   +1 more source

Enhancement of platelet response to immune complexes and IgG aggregates by lipid A-rich bacterial lipopolysaccharides. [PDF]

, 1978
The effect of the common lipid moiety of bacterial LPS on secretion from washed human platelets has been studied. The lipid A-rich LPS of S. minnesota R595 and a lipid A preparation both potentiated platelet serotonin secretion in response to IgG ...
Ginsberg, MH, Henson, PM
core   +1 more source

Microfluidic flow chambers using reconstituted blood to model hemostasis and platelet transfusion in vitro [PDF]

, 2016
Blood platelets prepared for transfusion gradually lose hemostatic function during storage. Platelet function can be investigated using a variety of (indirect) in vitro experiments, but none of these is as comprehensive as microfluidic flow chambers.
Compernolle, Veerle, Devloo, Rosalie, Feys, Hendrik, Van Aelst, Britt, Vandekerckhove, Philippe   +4 more
core   +2 more sources

Nanoparticle biointerfacing via platelet membrane cloaking

Nature, 2015
Development of functional nanoparticles can be encumbered by unanticipated material properties and biological events, which can affect nanoparticle effectiveness in complex, physiologically relevant systems.
C. J. Hu, Ronnie H. Fang, Kuei‐Chun Wang, Brian T. Luk, Soracha Thamphiwatana, Diana Dehaini, P. Nguyen, Pavimol Angsantikul, Cindy Wen, Ashley V. Kroll, Cody W. Carpenter, M. Ramesh, V. Qu, Sherrina H. Patel, Jie Zhu, W. Shi, F. Hofman, Thomas C Chen, Weiwei Gao, Kang Zhang, S. Chien, Liangfang Zhang   +21 more
semanticscholar   +1 more source

Expression of Regulatory Platelet MicroRNAs in Patients with Sickle Cell Disease [PDF]

, 2013
Background: Increased platelet activation in sickle cell disease (SCD) contributes to a state of hypercoagulability and confers a risk of thromboembolic complications.
A Abdollahi, A Dixon-McIver, A Osman, A Schedel, A Smolenski, A Tomer, AA Kondkar, AD Blann, AI Badeaux, AJ Saldanha, AM Healy, BM Steele, Claudia Coronnello, D Betel, D Betel, DA Hosack, DP Bartel, DV Gnatenko, EM Novelli, ER Popescu, G Bazzoni, Gregory J. Kato, Guoying Yu, H Bruchova, H Seitz, HA Brittain, I Hers, I Toma, J Villagra, Jen-Tsan Ashley Chi, JF Noronha, JS Mohan, K Joop, K Kaushansky, K Konishi, Kimberly Woodhouse, LL Horstman, LR Queen, M Kannan, M Kertesz, Maria G. Kapetanaki, Mark T. Gladwin, MC Ammons, ML Freedman, ML Jison, MP Hunter, N Chavda, N Raghavachari, Naftali Kaminski, Nalini Raghavachari, P Landry, Panayiotis V. Benos, PV Browne, R Antonucci, R Garzon, R Ross, R Visone, RC Friedman, RJ Berckmans, RL Nachman, RT Schermuly, S Amisten, S Kim, S Masaki, S Mendjan, S Nagalla, Shilpa Jain, SP Lee, Suchitra Barge, T Wun, V Ambros, W Huang da   +71 more
core   +7 more sources

Platelet Activation Pathways Controlling Reversible Integrin αIIbβ3 Activation

TH Open
Background Agonist-induced platelet activation, with the integrin αIIbβ3 conformational change, is required for fibrinogen binding. This is considered reversible under specific conditions, allowing a second phase of platelet aggregation.
Jinmi Zou, Siyu Sun, Ilaria De Simone, Hugo ten Cate, Philip G. de Groot, Bas de Laat, Mark Roest, Johan W.M. Heemskerk, Frauke Swieringa   +8 more
doaj   +1 more source